Summary
Paraffin-embedded surgical pathology specimens from skin (5) and muscle (2) biopsies, from Morton's neuromas (3), traumatic neuromas (8), schwannomas (21), neurofibromas (12), and from one perineurioma and one neurothekeoma were studied by immunoperoxidase histochemistry and antibodies against epithelial membrane antigen (EMA), Leu 7 epitopes (Leu 7), S-100 protein (S-100) and cytokeratins. Normal, reactive and neoplastic perineurial cells stain consistently for EMA, whereas Schwann cells express Leu 7 and/or S-100 positivity. None of the immunoreactive cells stained for cytokeratin. Our findings indicate that perineurial and Schwann cells can easily be distinguished by their different patterns of immunoreactivity with the above markers.
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Supported by a grant from the Fondation Suisse de Bourses de Médecine et Biologie (EP), by Neuropathology Training Grant T32 NS7236 from the N.I.N.C.D.S, U.S.D.H.H.S., by American Cancer Society Clinical Fellowship 86-276 (CS), and by Research Grant CA 31271 from the National Cancer Institute, US Department of Health and Human Services (LJR)
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Perentes, E., Nakagawa, Y., Ross, G.W. et al. Expression of epithelial membrane antigen in perineurial cells and their derivatives. Acta Neuropathol 75, 160–165 (1987). https://doi.org/10.1007/BF00687077
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DOI: https://doi.org/10.1007/BF00687077