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Periventricular pathology in hydrocephalic rabbits before and after shunting

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Summary

Hydrocephalus was induced in adult rabbits by injection of silicone oil into the cisterna magna. The frontal horns of the lateral ventricles enlarged to the greatest degree and reached maximum size within 3 days. Cilia and microvilli were progressively lost from the ependymal surface primarily over the corpus callosum. Stretching and flattening of ependymal cells was most pronounced over the septal area. Mitotic activity was significantly increased among ependymal cells and subependymal astrocytes over the caudate nucleus and corpus callosum during the 2 weeks immediately following induction of hydrocephalus. Cerebrospinal fluid shunting returned the ventricles to normal size. Following shunting, however, the periventricular tissue did not resume a normal appearance. Longer durations of hydrocephalus were associated with less recovery of the periventricular tissue following shunting.

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Authors and Affiliations

  1. Department of Surgery (Section of Neurosurgery), The University of Manitoba, 730 William Avenue, R3E OW3, Winnipeg, Manitoba, Canada

    M. R. Del Bigio

  2. Department of Anatomy, Faculty of Medicine, The University of Manitoba, 730 William Avenue, R3E OW3, Winnipeg, Manitoba, Canada

    J. E. Bruni

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  1. M. R. Del Bigio
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  2. J. E. Bruni
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Additional information

Supported by grants from the Health Sciences Centre Research Foundation, the Medical Research Council of Canada, the Manitoba Health Research Council, and the Manitoba Medical Services Foundation. Dr. Del Bigio was supported by a Fellowship from the Medical Research Council of Canada. This work was awarded the Kenneth Shulman Memorial Award by the Pediatric Section of the American Association of Neurological Surgeons.

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Del Bigio, M.R., Bruni, J.E. Periventricular pathology in hydrocephalic rabbits before and after shunting. Acta Neuropathol 77, 186–195 (1988). https://doi.org/10.1007/BF00687430

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  • DOI: https://doi.org/10.1007/BF00687430

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