Summary
An ununsual case of concurrent MS and anaplastic astrocytoma is presented.
MS was diagnosed in a female patient at the age of 22 years. A left side thalamotomy was performed for relief of severe intention tremor at age 28 and at age 32 she received immunosuppressive therapy for 1 year. At the age of 36 after a severe exacerbation of her symptoms a left side fronto-temporal tumor was diagnosed and a subtotal neurosurgical extirpation was performed. Histopathologically, the tumor was an anaplastic astrocytoma, which was further substantiated by electron microscopy and establishment of a permanent cell line in vitro. The cultured tumor cells were negative for measles virus by immunofluorescence. The relationship between the reactive astrocytes in MS plaques and astrocytic neoplasia is discussed.
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Kalimo, H., Frey, H., Raine, C.S. et al. Late-onset malignant astrocytoma in a case of multiple sclerosis. Acta Neuropathol 46, 231–234 (1979). https://doi.org/10.1007/BF00690850
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DOI: https://doi.org/10.1007/BF00690850