Abstract
Renal elimination of the paramagnetic contrast agent Gadolinium-DTPA (Gd-DTPA) was analyzed in 24 patients with impaired renal function and 3 normal controls. Dynamic magnetic resonance studies were performed using fast gradient-echo sequences with single images during suspended respiration and a temporal resolution of 10s per image. The time between appearance of the contrast agent in the renal cortex and signal intensity drop mL/min the medulla, due to a high concentration of Gd-DTPA and predominant T2-shortening, was an indicator of glomerular filtration rate and correlated well with creatinine clearance values (r=0.81). Fractionate urine collections and serum analysis up to 120h following administration showed a prolonged but complete elimination of Gd-DTPA mL/min patients with creatinine clearance above 20 mL/min. Renal functional parameters did not change after administration of Gd-DTPA and no nephrotoxic effects were observed.
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Krestin, G.P., Schuhmann-Giampieri, G., Haustein, J. et al. Functional dynamic MRI, pharmacokinetics and safety of Gd-DTPA in patients with impaired renal function. Eur. Radiol. 2, 16–23 (1992). https://doi.org/10.1007/BF00714176
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DOI: https://doi.org/10.1007/BF00714176