Summary
Bile canalicular structures of 32 hepatocellular carcinomas and 36 cirrhotic livers were investigated by light microscopy using immunohistochemistry for carcinoembryonic antigen (CEA) and lectin histochemistry. CEA positive bile canalicular structures were found in 17 out of 32(53%) hepatocellular carcinomas and in 33 of 36(92%) cirrhotic livers. Among the 10 lectins examined, about 40% of the CEA positive bile canalicular structures of hepatocellular carcinomas showed positive binding of MPA, DBA, WGA, RCA-I or UEA-I, whereas only MPA or RCA-I bound to the CEA positive bile canalicular structures of cirrhotic liver, in about 20% of cases. It has been shown that the CEA positive bile canalicular structures of hepatocellular carcinomas are heterogeneous and differ from those of cirrhotic liver in lectin histochemistry.
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References
Gerber MA, Thung SN, Shen S, Stromeyer FW, Ishak KG (1983) Phenotypic characterization of hepatic proliferation. Antigenic expression by proliferating epithelial cells in fetal liver, massive hepatic necrosis, and nodular transformation of the liver. Am J Pathol 110:70–74
Gulati AK, Zalewski AA, Sharma KB, Ogrowsky D, Sohal GS (1986) A comparison of lectin binding in rat and human peripheral nerve. J Histochem Cytochem 34:1487–1493
Hirohashi S, Shimosato Y, Ino Y, Kishi K, Ohkura H, Mukojima T (1983) Distribution of alpha-fetoprotein and immunoreactive carcinoembryonic antigen in human hepatocellular carcinoma and hepatoblastoma. Jpn J Clin Oncol 13:37–44
Kellokumpu I, Karhi K, Anderson LC (1986) Lectin-binding sites in normal, hyperplastic, adenomatous and carcinomatous human colorectal mucosa. Acta Pathol Microbiol Scand Sect A 94:271–280
Kellokumpu IH (1986) Differences in lectin reactivities of cellular gluycoconjugates between primary human colorectal carcinomas and their metastases. Cancer Res 46:4620–4625
Koelma IA, Nap M, Huitema S, Krom RAF, Houthoff HJ (1986) Hepatocellular carcinoma, adenoma, and focal nodular hyperplasia. Comparative histopathologic study with immunohistochemical parameters. Arch Pathol Lab Med 110:1035–1040
Kondo Y, Kondo K, Wada K, Okabayashi A (1986) Pathologic features of small hepatocellular carcinoma. Acta Pathol Jpn 36:1149–1161
Louis CJ, Sztynda T, Cheng Z-M, Wyllie RG (1983) Lectin-binding affinities of human breast tumors. Cancer 52:1244–1250
Macartney JC (1986) Lectin histochemistry of galactose and N-acetyl-galactosamine glycoconjugates in normal gastric mucosa and gastric cancer and the relationship with ABO and secretor status. J Pathol 150:135–144
Svenberg T, Hammarstrom S, Hedin A (1979) Purification and properties of biliary glycoprotein I (BGP I). Immunochemical relationship to carcinoembryonic antigen. Mol Immunol 16:245–252
Ulrich W, Horvat R, Krisch K (1985) Lectin histochemistry of kidney tumours and its pathomorphological relevance. Histopathology 9:1037–1050
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Machinami, R., Oono, Y. Carcinoembryonic antigen and lectin binding in the bile canalicular structures of hepatocellular carcinoma. Vichows Archiv A Pathol Anat 412, 111–118 (1987). https://doi.org/10.1007/BF00716182
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DOI: https://doi.org/10.1007/BF00716182