Summary
A new case of giant-cell tumour (GCT) of bone with benign histological features, clinical stage II, has been reviewed with immunohistochemistry and electron microscopy. After short-term tissue culture the karyotype, using G-banding techniques, presented a consistent translocation t(12;19)(q13;q13). Nude mice xenografts of the tumour were unsuccessful after 6 months of follow-up. Presence of such chromosomal rearrangement may be related to locally aggressive, histologically benign giant-cell tumors of bone.
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Supported by Grant N. 88/0146 of the FIS, Madrid
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Noguera, R., Llombart-Bosch, A., Lopez-Gines, C. et al. Giant-cell tumor of bone, stage II, displaying translocation t(12;19)(q13;q13). Vichows Archiv A Pathol Anat 415, 377–382 (1989). https://doi.org/10.1007/BF00718640
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DOI: https://doi.org/10.1007/BF00718640