Skip to main content
Log in

Motivational syndromes associated with natural killer cell activity

  • Published:
Journal of Behavioral Medicine Aims and scope Submit manuscript

Abstract

This article reports three studies that taken together support two hypotheses: (a) that the stressed power motivation syndrome is associated with relatively low natural killer cell activity (NKCA) and (b) that the unstressed affiliation motivation syndrome is associated with higher NKCA. In Study 1, college students who were relatively high in stressed power motivation had significantly lower NKCA than did their peers. In addition, students high in unstressed affiliation motivation had significantly greater NKCA than did those showing less evidence of this syndrome. Study 2 replicated these findings on a sample of middle-class men. In Study 3, which tested the hypotheses among adult patients from a Health Maintenance Organization, results were in the same direction but less significant. Meta-analyses clearly indicate that the combined evidence from the three studies reliably supports both hypotheses.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Atkinson, J. W. (ed.). (1958).Motives in Fantasy, Action, and Society, Van Nostrand, New York.

    Google Scholar 

  • Boyatzis, R. E. (1973). Affiliation motivation. In McClelland, D. C., and Steele, R. S. (eds.),Human Motivation, General Learning, Morristown, NJ, pp. 252–276.

    Google Scholar 

  • Cook, T. D., and Campbell, D. T. (1979).Quasi-Experimentation: Design and Analysis Issues for Field Settings, Rand McNally, Chicago.

    Google Scholar 

  • Cornfeld, D., and Hubbard, J. P. (1961). A four-year study of beta-hemolytic streptococci in 64 school children.N. Engl. J. Med. 264: 211.

    PubMed  Google Scholar 

  • Dorian, B. J., Keystone, E., Garfinkel, P. E., and Brown, G. M. (1982). Aberrations in lymphocyte subpopulations and functions during psychological stress.Clin. Exp. Immunol. 50: 132–138.

    PubMed  Google Scholar 

  • Goldberg, E. L., and Comstock, G. W. (1980). Epidemiology of life events: Frequencies in general populations.Am. J. Epidemiol. 111: 736–752.

    PubMed  Google Scholar 

  • Hays, W. L. (1981).Statistics, Holt, Rinehart & Winston, New York.

    Google Scholar 

  • Hedges, L. V., and Olkin, I. (1985).Statistical Methods for Meta-Analysis, Academic Press, New York.

    Google Scholar 

  • Herberman, R. B. (1982). Nautral killer cells.Hosp. Pract. April: 93–103.

    Google Scholar 

  • Herberman, R. B., and Holden, H. T. (1978). Natural cell-mediated immunity. In Klein, G., and Weinhouse, S. (eds.),Advances in Cancer Research, Academic Press, New York, Vol. 27, pp. 305–377.

    Google Scholar 

  • Holmes, T. H., and Masuda, M. (1974). Life change and illness susceptibility. In Dohrenwend, B. S., and Dohrenwend, B. P. (eds.),Stressful Life Events: Their Nature and Effects, Wiley, New York.

    Google Scholar 

  • Hurst, M. W. (1979). Life changes and psychiatric symptom development: Issues of content, scoring, and clustering. In Barrett, J., and Rose, R. (eds.),Stress and Mental Illness, Raven Press, New York.

    Google Scholar 

  • James, W. E. S., Badger, G. F., and Dingle, J. H. (1960). A study of illness in a group of Cleveland families: XIX. The epidemiology of the acquisition of group A streptococci and of associated illness.N. Engl. J. Med. 262: 687.

    PubMed  Google Scholar 

  • Jemmott, J. B., III (1987). Social motives and susceptibility to disease: Stalking individual differences in health risks.J. Personal. 55: 267–298.

    Google Scholar 

  • Jemmott, J. B., III, and Locke, S. E. (1984). Psychosocial factors, immunologic mediation, and human susceptibility to infectious diseases: How much do we know?Psychol. Bull. 95: 78–108.

    PubMed  Google Scholar 

  • Jemmott, J. B., III, and Magloire, K. (1988). Academic stress, social support, and secretory immunoglobulin A.J. Personal. Soc. Psychol. 55(5): 803–810.

    Google Scholar 

  • Jemmott, J. B., III, and McClelland, D. C. (1989). Secretory IgA as a measure of resistance to infectious disease: Comments on Stone, Cox, Valdimarsdottir, and Stone (1987).Behav. Med. 15: 63–71.

    PubMed  Google Scholar 

  • Jemmott, J. B., III, Borysenko, J. Z., Borysenko, M., McClelland, D. C., Chapman, R., Meyer, D., and Benson, H. (1983). Academic stress, power motivation, and decrease in salivary secretory immunoglobulin A secretion rate.Lancet 1: 1400–1402.

    PubMed  Google Scholar 

  • Kiecolt-Glaser, J. K., Garner, W., Speicher, C., Penn, G. M., Holliday, J., and Glaser, R. (1984a). Psychosocial modifiers of immunocompetence in medical students.Psychosom. Med. 46: 7–14.

    PubMed  Google Scholar 

  • Kiecolt-Glaser, J. K., Ricker, D., Messick, G., Speicher, C. E., Garner, W., and Glaser, R. (1984b). Urinary cortisol, cellular immunocompetency, and loneliness in psychiatry patients.Psychosom. Med. 46: 15–24.

    PubMed  Google Scholar 

  • Kiecolt-Glaser, J. K., Glaser, R., Williger, D., Stout, J., Messick, G., Sheppard, S., Ricker, D., Romisher, S. C., Briner, W., Bonnell, G., and Donnerberg, R. (1985). Psychosocial enhancement of immunocompetence in a geriatric population.Health Psychol. 4: 23–41.

    Google Scholar 

  • Kronfol, Z., Silva, J., Jr., Greden, J., Dembinski, S., Gardner, R., and Carroll, B. (1983). Impaired lymphocyte function in depressive illness.Life Sci. 33: 241–247.

    PubMed  Google Scholar 

  • Lazarus, R. S. (1970). Cognitive and personality factors underlying stress and coping. In Levine, S., and Scotch, N. (eds.),Social Stress, Aldine, Chicago.

    Google Scholar 

  • Linn, B. S., Linn, M. W., and Jenson, J. (1982). Degree of depression and immune responsiveness.Psychosom. Med. 44: 128 (abstract).

    Google Scholar 

  • Locke, S. E., Kraus, L., Leserman, J., Hurst, M. W., Heisel, J. S., and Williams, R. M. (1984). Life change stress, psychiatric symptoms, and natural killer cell activity.Psychosom. Med. 46: 441–453.

    PubMed  Google Scholar 

  • Lundy, A. (1985). The reliability of the Thematic Apperception Test.J. Personal. Assess. 49: 141–145.

    Google Scholar 

  • Mason, J. W. (1975). A historical view of the stress field. II.J. Hum. Stress 1(2): 22–36.

    Google Scholar 

  • McAdams, D. P., and Constantian, C. A. (1983). Intimacy and affiliation motives in daily living: An experience sampling analysis.J. Personal. Soc. Psychol. 45: 851–861.

    Google Scholar 

  • McClelland, D. C. (1975).Power: The Inner Experience, Irvington, New York.

    Google Scholar 

  • McClelland, D. C. (1980). Motive dispositions: The merits of operant and respondent measures. In Wheeler, L. (ed.),Review of Personality and Social Psychology (Vol. 1), Sage, Beverly Hills, CA.

    Google Scholar 

  • McClelland, D. C. (1985).Human Motivation, Scott, Foresman, Glenview, IL.

    Google Scholar 

  • McClelland, D. C., and Jemmott, J. B., III (1980). Power motivation, stress, and physical illness.J. Hum. Stress 6(4): 6–15.

    Google Scholar 

  • McClelland, D. C., Alexander, C., and Marks, E. (1982). The need for power, stress, immune function, and illness among male prisoners.J. Abnorm. Psychol. 91: 61–70.

    PubMed  Google Scholar 

  • McClelland, D. C., Floor, E., Davidson, R. J., and Saron, C. (1980). Stressed power motivation, sympathetic activation, immune function, and illness.J. Hum. Stress 6(2): 11–19.

    Google Scholar 

  • Mims, C. A. (1986).The Pathogenesis of Infectious Disease. Academic Press, New York.

    Google Scholar 

  • Mosteller, F. M., and Bush, R. R. (1954). Selected quantitative techniques. In Lindzey, G. (ed.),Handbook of Social Psychology (Vol. 1), Addison-Wesley, Cambridge, MA.

    Google Scholar 

  • Palmblad, J. (1981). Stress and immunocompetence: Studies in man. In Ader, R. (ed.),Psychoneuroimmunology, Academic Press, New York, pp. 229–257.

    Google Scholar 

  • Pross, H. F., and Baines, M. G. (1982). Studies of natural killer cells. I. In vivo parameters affecting normal cytotoxic function.Int. J. Cancer, 29: 383–390.

    PubMed  Google Scholar 

  • Rosenthal, R. (1978). Combining results of independent studies.Psychol. Bull. 85: 185–193.

    Google Scholar 

  • Rosenthal, R. (1984).Meta-Analytic Procedures for Social Research, Sage, Beverly Hills, CA.

    Google Scholar 

  • Rosenthal, R., and Rosnow, R. L. (1985).Contrast Analysis: Focused Comparisons in the Analysis of Variance, Cambridge University, New York.

    Google Scholar 

  • Rossen, R. D., Butler, W. T., Waldman, R. H., Alford, R. H., Hornick, R. B., Togo, Y., and Kasel, J. A. (1970). The protein in nasal secretions.JAMA 211: 1157–1161.

    PubMed  Google Scholar 

  • Stone, A., Cox, D. S., Valdimarsdottir, H., and Neale, J. M. (1987). Secretory IgA as a measure of immunocompetence.J. Hum. Stress 13: 136–140.

    Google Scholar 

  • Tomasi, T. B., and Grey, H. M. (1972). Structure and function of immunoglobulin A.Prog. Allergy 16: 81–213.

    PubMed  Google Scholar 

  • Webb, E. J., Campbell, D. T., Schwartz, R. D., Sechrest, K., and Grove, J. B. (1981).Nonreactive Measures in the Social Sciences, Houghton Mifflin, Boston, MA.

    Google Scholar 

  • Winer, B. J. (1971).Statistical Principles in Experimental Design, McGraw-Hill, New York.

    Google Scholar 

  • Winter, D. G. (1973).The Power Motive, Free Press, New York.

    Google Scholar 

  • Winter, D. G. (1980).Correcting Projective Test Scores for the Effect of Significant Correlation with Length of Protocol (Technical Note), McBer and Company, Boston, MA.

    Google Scholar 

  • Winter, D. G., and Stewart, A. J. (1977). Power motive reliability as a function of retest instructions.J. Consult. Clin. Psychol. 45: 436–440.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

This work was supported in part by Grant CA-29155 from the National Cancer Institute, Grant MH-1589 from the National Institute of Mental Health, Grant RR-01032 from the National Institutes of Health General Clinical Research Centers Program of the Division of Research Resources, Biomedical Research Support Grant RR-5487 (University Hospital), and a grant from the John D. and Catherine T. MacArthur Foundation. Additional support was provided under the Office of Naval Research Contract N-00014-79-C-1068 with funds of the Naval Medical Research and Developmental Command. The opinions or assertions contained herein are those of the authors and are not to be construed as official or reflecting the views of the Navy Department or Naval Service at large.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jemmott, J.B., Hellman, C., McClelland, D.C. et al. Motivational syndromes associated with natural killer cell activity. J Behav Med 13, 53–73 (1990). https://doi.org/10.1007/BF00844899

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00844899

Key words

Navigation