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Survival of cadaveric renal transplant grafts from young donors and in young recipients

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Abstract

Evidence from multicenter registries has suggested that cadaveric renal graft survival is poorer when either the recipient or the donor is very young. We therefore analyzed our results from a single pediatric center. There was a significant correlation between greater recipient age and improved cadaveric graft (P=0.002) and patient (P=0.0009) survival. The age of the donor also appeared important, particularly in very young children, but became less so as donor age rose. Forty-four percent of recipients under 3 years old who received cadaveric kidneys from donors less than 4 years old lost their grafts as a result of renal thrombosis, ischemia, or technical problems, compared with only 3% of recipients over 9 years of age, whose grafts came from donors who were also over 9 years. The 1-year first cadaveric graft survival rates for these two age groups were 33% and 82% respectively. Our experience confirms the poor findings reported in very young recipients and with very young donors.

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Authors and Affiliations

  1. Division of Nephrology, Department of Pediatrics, The Hospital for Sick Children, 555 University Avenue, M5G 1X8, Toronto, Ontario, Canada

    Gerald S. Arbus

  2. Department of Pediatrics, University of Toronto, 555 University Avenue, M5G 1X8, Toronto, Ontario, Canada

    Doris Thompson

  3. Department of Epidemilology and Biostatistics, University of Western Ontario, London, Ontario, Canada

    James Rochon

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  1. Gerald S. Arbus
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  2. James Rochon
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  3. Doris Thompson
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Arbus, G.S., Rochon, J. & Thompson, D. Survival of cadaveric renal transplant grafts from young donors and in young recipients. Pediatr Nephrol 5, 152–157 (1991). https://doi.org/10.1007/BF00852874

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