Abstract
Oxidant injury has been implicated in the pathogenesis of inflammotory, metabolic and toxic insults, in ischemic-reperfusion injury, and in carcinogenesis, aging and atherosclerosis. Oxidant injury is initiated by free radicals and reactive oxygen molecules which are generated by activated neutrophils, monocytes, and mesangial cells, during normal and abnormal metabolic processes, and from the metabolism of exogenous drugs and toxins. When cells and organs are exposed to oxidant stress, several different antioxidant defense mechanisms operate to prevent or limit oxidant injury. When antioxidant defense mechanisms are decreased, or when the generation of reactive oxygen molecules is increased, oxidant injury results from the shift in the oxidant/antioxidant balance. Oxidant-induced alterations of proteins, membranes, DNA, and basement membranes leads to cell and organ dysfunction. Several renal diseases including glomerulonephritis, vasculitis, toxic nephropathies, pyelonephritis, acute renal failure, and others are likeky to be mediated at least in part by oxidant injury. In the future, mechanisms to decrease the generation of reactive oxygen molecules and/or antioxidant therapy may develop into new avenues of therapeutic intervention.
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Cross CE, Halliwell B, Borish ET, Pryor WA, Ames BN, Saul RL, McCord JM, Harmon D (1988) Oxygen radicals and human disease. Ann Intern Med 107: 526–545
Halliwell B (1987) Oxidants and human disease: some new concepts. FASEB J 1: 388–364
McCord JM, Fridovich I (1978) The biology and pathology of oxygen radicals. Ann Intern Med 89: 122–127
Floyd RA (1990) Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J 4: 2587–2597
Fridovich I (1976) Oxygen radicals, hydrogen peroxide, and oxygen toxicity. In: Pryor WA (ed) Free radicals in biology, vol 1. Academic Press, New York pp 239–277
Suzuki M, Inauen W, Kvietys PR, Grisham MB, Meininger C, Schelling ME, Granger HJ, Granger DN (1989) Superoxide mediates reperfusion-induced leukocyte-endothelial cell interactions. Am J Physiol 257: H1740-H1745
Anonymous (1985) Metal chelation therapy, oxygen radicals, and human disease. Lancet I: 143–145
Babior BM (1984) The respiratory burst of phagocytes. J Clin Invest 73: 599–601
Malech HL, Gallin JI (1987) Neutrophils in human disease. N Engl J Med 317: 687–694
Weiss SJ (1989) Tissue destruction by neutrophils. N Engl J Med 320: 365–376
Test ST, Lampert MB, Ossanna PJ, Thoene JG, Weiss SJ (1984) Generation of nitrogen-chlorine oxidants by human phagocytes. J Clin Invest 74: 1341–1349
Baud L, Ardaillou R (1986) Reactive oxygen species: production and role in the Kidney. Am J Physiol 251: F765-F776
Adler S, Baker PJ, Johnson RJ, Ochi RF, Pritzi P, Couser WG (1986) Complement membrane attack complex stimulates production of reactive oxygen metabolites by cultured rat mesangial cells. J Clin Invest 77: 762–767
Baud L, Hagege J, Sraer J, Rondeau E, Perez J, Ardaillou R (1983) Reactive oxygen production by cultured rat glomerular mesangial cells during phagocytosis in associated with stimulation of lipoxygenase activity. J Exp Med 158: 1836–1852
Horton JK, Davies M, Topley N, Thomas D, Williams JD (1990) Activation of the inflammatory response of neutrophils by Tamm-Horsfall glycoprotein. Kidney Int 37: 717–726
Nathan CF (1987) Neutrophil activation on biological surfaces. J Clin Invest 80: 1550–1560
Janco RL, English D (1983) Regulation of monocyte oxidative metabolism: chemotactic factor enhancement of superoxide release, hydroxyl radical generation, and chemiluminescence. J Lab Clin Med 102: 890–898
Johnston RB, Kitagawa S (1985) Molecular basis for the enhanced respiratory burst of activated macrophages. Fed Proc 44: 2927–2932
Freeman BA, Crapo JD (1982) Biology of disease: free radicals and tissue injury. Lab Invest 47: 412–426
Chance B, Seis H, Booeris A (1979) Hydroperoxide metabolism in mammalian organs. Physiol Rev 59: 527–605
McCord JM (1985) Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 312: 159–163
McKelvey TG, Hollwarth ME, Granger DN, Engerson TD, Landler U, Jones HP (1988) Mechanisms of conversion of xanthine dehydrogenase to xanthine oxidase in ischemic rat liver and kidney. Am J Physiol 254: G753-G760
Morgan TR, Laudone VP, Heston WDW, Zeitz L, Fair WR (1988) Free radical production by high energy shock waves-comparison with ionizing irradiation. J Urol 139: 186–189
McCoy RN, Hill KE, Ayon MA, Stein JH, Burk RF (1988) Oxidant stress following renal ischemia: changes in the glutathione redox ratio. Kidney Int 33: 812–817
Beckman JS, Minor RL, White CW, Repine JE, Rosen GM, Freeman BA (1988) Superoxide dismutase and catalase conjugated to polyethylene glycol increases endothelial enzyme activity and oxidant resistance. J Biol Chem 263: 6884–6892
Andreoli SP, Mallett CH, Bergstein JM (1986) Role of glutathione in protecting endothelial cells against hydrogen peroxide oxidant injury. J Lab Clin Med 108: 190–198
Hagen TM, Aw TY, Jones DP (1988) Glutathione uptake and protection against oxidative injury in isolated kidney cells. Kidney Int 34: 74–81
Harlan JM, Levine JD, Callahan KS, Schwartz BR (1984) Glutathione redox cycle protects cultured endothelial cells against lysis by extracellularly generated hydrogen peroxide. J Clin Invest 73: 706–713
Messana JM, Cieslinski DA, O'Connor RP, Humes HD (1988) Glutathione protects against exogenous oxidant injury to rabbit renal proximal tubules. Am J Physiol 255: F874-F884
Andreoli SP, McAteer JA Antioxidant defense mechanisms of endothelial cells and renal tubular epithelial cells: role of the glutathione redox cycle and catalase. Pediatr Res 27: 323a
Broadley C, Hoover RL (1989) Ceruloplasmin reduces the adhesion and scavenges superoxide during the interaction of activated polymorphonuclear leukocytes with endothelial cells. Am J Pathol 135: 647–655
Machlin LJ, Bendich A (1987) Free radical tissue damage: protective role of antioxidant nutrients. FASEB J 1: 441–445
Andreoli SP, McAteer JM (1990) Reactive oxygen molecule mediated injury in vitro: differential response by endothelial cells and renal tubule epithelial cells. Kidney Int 38: 785–794
Lash LH, Tokarz JJ (1990) Oxidative stress in isolated rat renal proximal and distal tubular cells. Am J Physiol 259: F338-F347
Hayashibe H, Asayama K, Dobashi K, Kato K (1990) Prenatal development of antioxidant enzymes in rat lung, kidney, and heart: marked increase in immunoreactive superoxide dismutases, glutathione peroxidase, and catalase in the kidney. Pediatr Res 27: 472–475
Mak IT, Weglicki WB (1988) Protection by B-blocking agents against free radical-mediated sarcolemmal lipid peroxidation. Circ Res 63:262–266
Andreoli SP (1990) Captopril scavenges hydrogen peroxide and lessens oxidant induced ATP depletion in NHK-C and endothelial cells. J Am Soc Nephrol 1:606a
Parthasarathy S, Young SG, Witztum JL, Pittman RC, Steinberg D (1986) Probucol inhibits oxidative modification of low density lipo-protein. J Clin Invest 77: 641–644
Sagone AL, Democko C, Clark L, Kartha M (1983) Determination of hydroxyl radical production in aqueous solutions irradiated to clinically significant doses. J Lab Clin Med 101: 196–204
Stadtman ER (1990) Metal ion-catalyzed oxidation of proteins: biochemical mechanism and biological consequences. Free Radic Biol Med 9: 315–325
Farber JL, Kyle ME, Coleman JB (1990) Mechanisms of cell injury by activated oxygen species. Lab Invest 62: 670–679
Schraufstatter IU, Hyslop PA, Jackson JH, Cochrane CG (1988) Oxidant-induced DNA damage of target cells. J Clin Invest 82: 1040–1050
Schraufstatter IU, Hinshaw DB, Hyslop PA, Spragg RG, Cochrane CG (1985) Glutathione cycle activity and pyridine nucleotide levels in oxidant-induced injury of cells. J Clin Invest 76: 1131–1139
Spragg RG, Hinshaw DB, Hyslop PA, Schraufstatter IU, Cochrane CG (1985) Alterations in adenosine triphosphate and energy charge in cultured endothelial and P388D cells after oxidant injury. J Clin Invest 76: 1471–1476
Hyslop PA, Hinshaw DB, Schraufstatter IU, Sklar LA, Spragg RG, Cochrane CG (1986) Intracellular calcium homeostasis during hydrogen peroxide injury to cultured P388D, cells. J Cell Physiol 129: 356–366
Andreoli SP (1989) Mechanisms of endothelial cell ATP depletion after oxidant injury. Pediatr Res 25: 97–101
Andreoli SP, Bachner RL, Bergstein JM (1985) In vitro detection of endothelial cell damage utilizing 2-deoxy-D-3H-glucose: comparison with51chromium,3H-adenine and LDH. J Lab Clin Med 106: 253
Schraufstatter IU, Hinshaw DB, Hyslop PA, Spragg RG, Cochrane CG (1986) Oxidant injury of cells. J Clin Invest 77: 1312–1320
Hyslop PA, Hinshaw DB, Halsey WA Jr, Schraufstatter IU, Sauerheber RD, Spragg RG, Jackson JH, Cochrane CG (1985) Mechanisms of oxidant-mediated cell injury. J Biol Chem 263: 1665–1675
Andreoli SP, Leichty EA, Mallett C (1990) Exogenous adenine nucleotides replete endothelial cell adenosine triphosphate after oxidant injury by adenosine uptake. J Lab Clin Med 115: 304–313
Orrenius S, McConkey DJ, Nicotera P (1988) Mechanisms of oxidant-induced cell damage. In: Ceruti PA, Fridovich I, McCord J (eds) Oxy-radicals in molecular biology and pathology. Liss, New York, New York, pp 327–339
Scott JA, Khaw BA, Homcy CJ, Rabito CA (1987) Oxygen radicals alter the cell membrane potential in a renal cell line (LLC-PK1) with differentiated characteristics of proximal tubular cells. 897: 25–32
Welsh MJ, Shasby DM, Husted RM (1985) Oxidants increase paracellular permeability in a cultured epithelial cell line. J Clin Invest 76: 1155–1168
Band L, Nivez MP, Chansel D, Ardaillou R (1981) Stimulation by oxygen radicals of prostaglandin production by rat renal glomeruli. Kidney Int 20: 332–339
Shah SV (1984) Effect of enzymatically generated reactive oxygen metabolites on the cyclic nucleotide content in isolated rat glomeruli. J Clin Invest 73: 393–401
Fligiel SEG, Lee EC, McCoy JP, Johnson KJ, Varani J (1984) Protein degradation following treatment with hydrogen peroxide. Am J Pathol 115: 418–425
Vissers MCM, Wiggins R, Fantone JC (1989) Comparative ability of human monocytes and neutrophils to degrade glomerular basement membrane in vitro. Lab Invest 60: 831–838
Johnson RJ, Couser WG, Alpers CE, Vissers M, Schulze M, Klebanoff SJ (1988) The human neutrophil serine proteinases, elastase and cathepsin G, can mediate glomerular injury in vivo. J Exp Med 168: 1169–1174
Shah SV, Baricos WH, Basci A (1987) Degradation of human glomerular basement membrane by stimulated neutrophils. J Clin Invest 79: 25–31
Rubanyi GM (1988) Vascular effects of oxygen-derived free radicals. Free Radio Biol Med 4: 107–120
Gryglewski RJ, Palmer RMJ, Moncada S (1986) Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature 320: 454–456
Shah SV (1989) Role of reactive oxygen metabolites in experimental glomerular disease. Kidney Int 35: 1093–1106
Rehan A, Johnson KJ, Kunkel RG, Wiggins RC (1985) Role of oxygen radicals in phorbol myristate acetate-induced glomerular injury. Kidney Int 27: 503–511
Yoshioka T, Ichikawa I (1989) Glomerular dysfunction induced by polymorphonuclear leukocyte-derived reactive oxygen species. Am J Physiol 257: F53-F59
Rehan A, Wiggins RC, Kunkel RG, Till GO, Johnson KJ (1986) Glomerular injury and proteinuria in rats after intrarenal injection of cobra venom factor. Am J Pathol 123: 57–66
Johnson RJ, Couser WG, Chi EY, Adler S, Kiebanoff SJ (1987) New mechanism for glomerular injury. J Clin Invest 79: 1379–1387
Johnson RJ, Guggenheim SJ, Klebanoff SJ, Ochi RF, Wass A, Baker P, Schulze M, Couser WG (1988) Morphologic correlates of glomerular oxidant injury induced by the myeloperoxidase-hydrogen peroxide-halide system of the neutrophil. Lab Invest 5: 294–301
Rehan A, Johnson KJ, Wiggins RC, Kunkel RG, Ward PA (1984) Evidence for the role of oxygen radicals in acute nephrotoxic nephritis. Lab Invest 51: 396–403
Tucker BJ, Gushwa LC, Wilson CB, Blantz RC (1985) Effect of leukocyte depletion on glomerular dynamics during acute glomerular immune injury. Kidney Int 28: 28–35
Boyce NW, Holdsworth SR (1986) Hydroxyl radical mediation of immune renal injury by desferrioxamine. Kidney Int 30: 813–817
Tomosugi NI, Cashman SJ, Hay H, Pusey CD, Evans DJ, Shaw A, Rees AJ (1989) Modulation of antibody-mediated glomerular injury in vivo by bacterial lipopolysaccharide, tumor necrosis factor, and IL-1. J Immunol 142: 3083–3090
Boyce NW, Tipping PG, Holdsworth SR (1989) Glomerular macrophages produce reactive oxygen species in experimental glomerulonephritis. Kidney Int 35: 778–782
Falk JR, Jennette JC (1988) Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. N Engl J Med 318: 1651–1657
Jennette JC, Wilkman AS, Falk RJ (1989) Anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis and vasculitis. Am J Pathol 135: 921–930
Falk RJ, Terrell RS, Charles LA, Jennette JC (1990) Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc Natl Acad Sci USA 87: 4115–4119
Shah SV (1988) Evidence suggesting a role for hydroxyl radical in passive Heymann nephritis in rats. Am J Physiol 254: F337-F344
Rahman MA, Emancipator SS, Sedor JR (1988) Hydroxyl radical scavengers ameliorate proteinuria in rat immune complex glomerulonephritis. J Lab Clin Med 112: 619–626
Paller MS, Hoidal JR, Ferris TF (1984) Oxygen free radicals in ischemic acute renal failure in the rat. J Clin Invest 74: 1156–1164
Paller MS, Hedlund BE (1988) Role of iron in postischemic renal injury in the rat. Kidney Int 34: 474–480
Linas SL, Whittenburg D, Repine JE (1990) role of xanthine oxidase in ischemia/reperfusion injury. Am J Physiol 258: F711-F716
Nath KA, Paller MS (1990) Dietary deficiency of antioxidants exacerbates ischemic injury in the rat kidney. Kidney Int 38: 1109–1117
Linas SL, Shanley PF, Whittenburg D, Berger E, Repine JE (1988) Neutrophils accentuate ischemic-reperfusion injury in isolated perfused rat kidneys. Am J Physiol 255: F728-F735
Hellberg POA, Kallskog TOK (1989) Neutrophil-mediated postischemic tubular leakage in the rat kidney. Kidney Int 36: 555–561
Koyama I, Bulkley GB, Williams GM, Im MJ (1985) The role of oxygen free radicals in mediating the reperfusion injury of cold-preserved ischemic kidneys. Transplantation 40: 590–595
Bry WI, Collins GM, Halasz NA, Jellinek M (1984) Improved function of perfused rabbit kidneys by prevention of oxidative injury. Transplantation 38: 579–582
Gamelin LM, Zager RA (1988) Evidence against oxidant injury as a critical mediator of postischemic acute renal failure. Am J Physiol 255: F450-F460
Joannidis M, Gstraunthaler G, Pfaller W (1990) Xanthine oxidase: evidence against a causative role in renal reperfusion injury. Am J Physiol 258: F232-F236
Borkan SC, Schwartz JH (1989) Role of oxygen free radical species in in vitro models of proximal tubular ischemia. Am J Physiol 257: F114-F125
Doctor RB, Mandel LJ (1991) Minimal role of xanthine oxidase and oxygen free radicals in rat renal tubular reoxygenation injury. J Am Soc Nephrol 1: 959–969
Thornton MA, Winn R, Alpers CE, Zager RA (1989) An evaluation of the neutrophil as a mediator of in vivo renal ischemic-reperfusion injury. Am J Pathol 135: 509–515
Paller MS (1989) Effect of neutrophil depletion on ischemic renal injury in the rat. J Lab Clin Med 113: 379–386
Linas SL, Whittenburg D, Repine JE (1987) O2 metabolites cause reperfusion injury after short but not prolonged renal ischemia. Am J Physiol 253: F685-F691
Diamond JR, Bonventre JV, Karnovsky MJ (1986) A role for oxygen free radicals in aminonucleoside nephrosis. Kidney Int 29: 478–483
Thakur V, Walker PD, Shah SV (1988) Evidence suggesting a role for hydroxyl radical in puromycin aminonucleoside-induced proteinuria. Kidney Int 34: 494–499
Beaman M, Birtwistle R, Howie AJ, Michael J, Adu D (1987) The role of superoxide anion and hydrogen peroxide in glomerular injury induced by puromycin aminonucleoside in rats. Clin Sci 73: 329–332
Doroshow JH, Locker GY, Ifrim I, Myers CE (1981) Prevention of doxorubicin cardiac toxicity in the mouse byN-acetylcysteine. J Clin Invest 68: 1053–1064
Myers CE, McGuire WP, Liss RH, Iprim I, Grotzinger K, Young RC (1977) Adriamycin: the role of lipid peroxidation in cardiac toxixity and tumor response. Science 197: 165–167
Thayer WS (1988) Evaluation of tissue indicators of oxidation stress in rats treated chronically with Adriamycin. Biochem Pharmacol 37: 2189–2194
Ohishi A, Suzuki H, Nakamoto H, Katsumata H, Sakaguchi H, Saruta T (1989) Differences in the effects of angiotensin converting enzyme inhibitors with or without a thiol group in chronic renal failure in rats. Clin Sci 76: 353–356
Shah SV, Walker PD (1988) Evidence suggesting a role for hydroxyl radical in glycerol-induced acute renal failure. Am J Physiol 255: F438-F443
Paller MS (1988) Hemoglobin- and myoglobin-induced acute renal failure in rats: role of iron in nephrotoxicity. Am J Physiol 255: F539-F544
Walker PD, Shah SV (1987) Gentamicin enhanced production of hydrogen peroxide by renal cortical mitochondria. Am J Physiol 253: C495-C499
Walker PD, Shah SV (1988) Evidence suggesting a role for hydroxyl radical in gentamicin-induced acute renal failure in rats. J Clin Invest 81: 334–341
Bakris GL, Lass N, Gaber AO, Jones JD, Burnett JC Jr (1990) Radiocontrast medium-induced declines in renal function: a role for oxygen free radicals. Am J Physiol 258: F115-F120
Hanneman J, Baumann K (1988) Cisplatin-induced lipid peroxidation and decrease of gluconeogenesis in rat kidney cortex: different effects of antioxidants and radical scavengers. Toxicology 51: 119–132
O'Regan S, Fong JSC (1978) Lipid peroxidation in the hemolytic uremic syndrome. Medical Hypothesis 4: 353–361
O'Regan S, Chesney RW, Kaplan BS, Drummond KN (1980) Red cell membrane phospholipid abnormalities in the hemolytic uremic syndrome. Clin Nephrol 15: 14–17
Milford D, Taylor CM, Rafaat F, Halloran E, Dawes J (1989) Neutrophil elastases and haemolytic uraemic syndrome. Lancet II: 1153
Forsyth KD, Simpson AC, Fitzpatrick MM, Barratt TM, Levinsky RJ (1989) Neutrophil-mediated endothelial injury in haemolytic ureamic syndrome. Lancet II: 411–414
Vedanarayanan VV, Kaplan BS, Fong JSC (1987) Neutrophil function in an experimental model of hemolytic uremic syndrome. Pediatr Res 21: 252–256
Walters MDS, Matthei IU, Kay R, Dillon MJ, Barratt TM (1989) The polymorphonuclear leucocyte count in childhood haemolytic uraemic syndrome. Pediatr Nephrol 3: 130–134
Karmali MA, Petric M, Lim C, Fleming PC, Arbus GS, Lior H (1985) The association between idiopathic hemolytic uremic syndrome and infection by verotoxin-producingEscherichia coli. J Infect Dis 151: 775–782
Milford DV, Taylor CM (1990) New insights into the haemolytic uraemic syndromes. Arch Dis Child 65: 713–715
Cotran RS, Pober JS (1990) Cytokine-endothelial interactions in inflammation, immunity, and vascular injury. J Am Soc Nephrol 1: 225–235
Moore KL, Andreoli SP, Esmon NL, Esmon CT, Bang NU (1987) Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro. J Clin Invest 79: 124–130
Harris DC, Chan H, Schrier RW (1988) Remnant kidney hypermetabolism and progression of chronic renal failure. Am J Physiol: F267–F276
Schrier RW, Harris DCH, Chan L, Shapiro JI, Caramelo C (1988) Tubular hypermetabolism as a factor in the progression of chronic renal failure. Am J Kidney Dis 12: 243–249
Nath KA, Croatt AJ, Hostetter TH (1990) Oxygen consumption and oxidant stress in surviving nephrons. Am J Physiol 258: F1354-F1362
Nath KA, Salahudeen AK (1990) Induction of renal growth and injury in the intact rat kidney by dietary deficiency of antioxidants. J Clin Invest 86: 1179–1192
Glauser MP, Neylan P, Bille J (1987) The inflammatory response and tissue damage. Pediatr Nephrol 1: 615–622
Glauser MP, Lyons JM, Braude AI (1978) Prevention of chronic experimental pyelonephritis by suppression of acute suppuration. J Clin Invest 61: 403–407
Bille J, Glauser MP (1982) Protection against chronic pyelonephritis in rats by suppression of acute suppuration: effect of colchicine and neutropenia. J Infect Dis 146: 220–226
Topley N, Steadman R, Mackenzie R, Knowlden JM, Williams JD (1989) Type I fimbriate strains ofEscherichia coli initiate renal parenchymal scarring. Kidney Int 36: 609–616
Bergstein J, Andreoli SP, Provisor AJ, Yum M (1986) Radiation nephritis following total-body irradiation and cyclophosphamide in preparation for bone marrow transplantation. Transplantation 41: 63–66
Antignac C, Gubler MC, Leverger G, Broyer M, Habib R, Lacoste M, Beziau A, Naizot C (1989) Delayed renal failure with extensive mesangiolysis following bone marrow transplantation. Kidney Int 35: 1336–1344
Loomis LJ, Aaronson AJ, Rudinsky R, Spargo BH (1989) Hemolytic uremic syndrome following bone marrow transplantation: a case report and review of the literature. Am J Kidney Dis 14: 324–328
Dunn MM, Drab EA, Rubin DB (1986) Effects of irradiation on endothelial cell-polymorphonuclear leukocyte interactions. J Appl Physiol 60: 1932–1937
Williams CM, Kaude JV, Newman RC, Peterson JC, Thomas WC (1988) Extracorporeal shock-wave lithotripsy: long-term complications. AJR 150: 311–315
Lingeman JE, Woods JR, Toth PD (1990) Blood pressure changes following extracorporeal shock wave lithotripsy and other forms of treatment for nephrolithiasis. JAMA 263: 1789–1794
Harris KPG, Schreiner GF, Klahr S (1989) Effect of leukocyte depletion on the function of the postobstructed kidney in the rat. Kidney Int 36: 210–215
Modi KS, Morrissey J, Shah SV, Schreiner GF, Klahr S (1990) Effects of probucol on renal function in rats with bilateral ureteral obstruction. Kidney Int 38: 843–850
Halliwell B (1989) Free radicals, reactive oxygen species and human disease: a critical evaluation with special reference to atherosclerosis. Br J Exp Pathol 70: 737–757
Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witzum JL (1989) Beyond cholesterol. Modification of low-density lipoprotein that increases its atherogenicity. N Engl J Med 320: 915–924
Gutteridge JMC, Quinlan GJ, Clark I, Halliwell B (1985) Aluminum salts accelerate peroxidation of membrane lipids stimulated by iron salts. Biochim Biophys Acta 835: 441–447
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Andreoli, S.P. Reactive oxygen molecules, oxidant injury and renal disease. Pediatr Nephrol 5, 733–742 (1991). https://doi.org/10.1007/BF00857888
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DOI: https://doi.org/10.1007/BF00857888