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Etiology of chronic renal failure in Turkish children

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Abstract

The etiology of chronic renal failure (CRF) was studied in 459 Turkish children (205 girls, 254 boys) for the period January 1979-December 1993. Their mean age at onset of CRF was 9.5±4.2 years (range 1–16 years); CRF was defined as a glomerular filtration rate (GFR) below 50 ml/min per 1.73 m2 for at least 6 months. When a GFR determination was not available, the serum creatinine concentration was used: greater than 1 mg/dl for children aged 1–3 years, greater than 1.5 mg/dl for those 3–10 years and greater than 2 mg/dl for those 10–16 years. Primary renal disorders were as follows: reflux nephropathy 32.4% glomerular diseases 22.2%, hereditary renal disorders 11.4%, amyloidosis 10.6%, urinary stones 8% and other renal disorders 15.4%. Twenty-three cases of reflux nephropathy (15.4%) were associated with neural tube defects (NTD) and 20 (13.4%) were caused by infravesical obstruction. CRF caused vesicoureteral reflux associated with NTD and amyloidosis are more frequent in our series compared with west European and Nordic countries.

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Authors and Affiliations

  1. Department of Pediatric Nephrology, Medical Faculty of Istanbul, TR-34390, Çapa, Istanbul, Turkey

    Aydan Şirin, Sevinç Emre, Harika Alpay, Ahmet Nayir, Ilmay Bilge & Faik Tanman

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  1. Aydan Şirin
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  2. Sevinç Emre
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  3. Harika Alpay
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  4. Ahmet Nayir
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  5. Ilmay Bilge
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Şirin, A., Emre, S., Alpay, H. et al. Etiology of chronic renal failure in Turkish children. Pediatr Nephrol 9, 549–552 (1995). https://doi.org/10.1007/BF00860926

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  • DOI: https://doi.org/10.1007/BF00860926

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