Abstract
Vaccination against hepatitis B virus (HBV) was performed in 18 boys (aged 5.7±2.4 years) suffering from steroid-sensitive nephrotic syndrome (SSNS) and in a control group of 21 healthy boys (aged 5.6±3.8 years). The percentage of patients who responded to vaccination was significantly lower than the control group 1, 6, 8, 12, 18 and 24 months after the start of vaccination. The titre of antibodies to HBV surface antigen produced by responders at 6 and 24 months was significantly lower in patients than in the control group. Boys with SSNS have an impaired response to HBV vaccination.
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References
La Manna A, Polito C, Del Gado R, Olivieri AN, Di Toro R (1985) Hepatitis B surface antigenaemia and glomerulopathies in children. Acta Paediatr Scand 74: 122–125
Kleinknecht C, Levy M, Peix A, Broyer M, Courtecuisse V (1979) Membranous glomerulonephritis and hepatitis B surface antigen in children. J Pediatr 95: 946–952
Del Vecchio Blanco C, Polito C, Caporaso N, Del Gado R, Busachi AC, Coltorti M, Di Toro R (1983) Membranous glomerulopathy and hepatitis B virus (HBV) infection in children. Int J Pediatr Nephrol 4: 235–238
International Study of Kidney Disease in Children (1978) The nephrotic syndrome in children. Prediction of histopathology from clinical and laboratory characteristics at the time of diagnosis. Kidney Int 13: 159–165
Schnaper HW (1989) The immune system in minimal change nephrotic syndrome. Pediatr Nephrol 3: 101–110
O'Regan E, O'Callaghan V, Dundon S (1980) HLA antigens and steroid responsive nephrotic syndrome of childhood. Tissue Antigens 16: 147–151
Alper CA, Kruskall MS, Marcus-Bagley D, Craven DE, Katz AJ, Brink SJ, Dienstag JL, Awdeh Z, Yunis EJ (1989) Genetic prediction of nonresponse to hepatitis B vaccine. N Engl J Med 321: 708–712
Lagueruela CC, Buettner TL, Cole BR, Kissane JM, Robson AM (1990) HLA extended haplotypes in steroid-sensitive nephrotic syndrome in childhood. Kidney Int 38: 145–150
Kato Y, Miyamori H, Unoura M, Ohimizo R, Tanaka N, Kobayashi K, Hattori N (1986) Clinical trial of hepatitis B vaccine in the families of HBV carriers. J Clin Gastroenterol 8: 545–549
Lok AS, Lai Cl, Wu PC, Ng MM (1986) Response to hepatitis B vaccine in family members of HBsAg carriers. J Med Virol 19: 33–39
Hwang LY, Beasley RP, Stevens CE, Szmuness W (1983) Immunogenicity of HBV vaccine in healthy Chinese children. Vaccine 1: 10–12
Blumberg BS, Sutnik AI, London WT, Melartin L (1972) Sex distribution of Australia antigen. Arch Intern Med 130: 227–231
Chiaramonte M, Floreani A, Giani G (1982) Sex differences in HBsAg and antiHBs distribution. Hepatogastroenterology 29: 13
Kleinknecht C, Gubler MC (1983) Néphrose. In: Royer P, Habib R, Mathieu H, Broyer M (eds) Néphrologie pediatrique, 3rd edn. Flammarion, Paris, pp 274–293
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La Manna, A., Polito, C., Foglia, A.C. et al. Reduced response to hepatitis B virus vaccination in boys with steroid-sensitive nephrotic syndrome. Pediatr Nephrol 6, 251–253 (1992). https://doi.org/10.1007/BF00878360
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DOI: https://doi.org/10.1007/BF00878360