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Newly identified γδ and βδ T-cell receptors

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References

  1. Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC: Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329:506–518, 1987

    Google Scholar 

  2. Brown JH, Jardetzky T, Saper MA, Samraoui B, Bjorkman PJ, Wiley DC: A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules. Nature 332:845–850, 1988

    Google Scholar 

  3. Marrack P, Kappler J: The antigen-specific, major histocompatibility complex-restricted receptor on T cells. Adv Immunol 38:1–30, 1986

    Google Scholar 

  4. Lesk AM, Chothia C: Evolution of proteins formed by β-sheets. The core of the immunoglobulin domains. J Mol Biol 160:325–342, 1982

    Google Scholar 

  5. Chothia C, Boswell DR, Lesk AM: The outline structure of the T-cell αβ receptor. EMBO J 7:3745–3755, 1988

    Google Scholar 

  6. Davis MM, Bjorkman PJ: T-cell antigen receptor genes and T-cell recognition. Nature 334:395–402, 1988

    Google Scholar 

  7. Brenner MB, McLean J, Dialynas DP, Strominger JL, Smith JA, Owen FL, Seidman JG, Ip S, Rosen F, Krangel MS: Identification of a putative second T-cell receptor. Nature 322:145–149, 1986

    Google Scholar 

  8. Forster A, Huck S, Ghanem N, Lefranc M-P, Rabbitts TH: New subgroups in the human T cell rearranging Vγ gene locus. EMBO J 6:1945–1950, 1987

    Google Scholar 

  9. Strauss WM, Quertermous T, Seidman JG: Measuring the human T cell receptor γ-chain locus. Science 237:1217–1219, 1987

    Google Scholar 

  10. Huck S, Dariavach P, Lefranc M-P: Variable region genes in the human T-cell rearranging gamma (TRG) locus: V-J junction and homology with the mouse genes. EMBO J 7:719–726, 1988

    Google Scholar 

  11. Lefranc M-P, Forster A, Baer R, Stinson MA, Rabbitts TH: Diversity and rearrangement of the human T cell rearranging γ genes: Nine germ-line variable genes belonging to two subgroups. Cell 45:237–246, 1986

    Google Scholar 

  12. Bories JC, Guglielmi P, Sigaux F, Bensussan A: Nucleotide sequence of a cDNA corresponding to a new human variable region of a functionally rearranged T cell receptor gamma chain. Nucl Acids Res 15:10059, 1987

    Google Scholar 

  13. Lefranc M-P, Forster A, Rabbitts TH: Genetic polymorphism and exon changes of the constant regions of the human T-cell rearranging gene γ. Proc Natl Acad Sci USA 83:9596–9600, 1986

    Google Scholar 

  14. Pelicci PG, Subar M, Weiss A, Dalla-Favera R, Littman DR: Molecular diversity of the human T-gamma constant region genes. Science 237:1051–1055, 1987

    Google Scholar 

  15. Li Y, Szabo P, Posnett DN: Molecular genotypes of the human T cell receptor γ-chain. J Immunol 140:1300–1303, 1988

    Google Scholar 

  16. Hayday AC, Saito H, Gillies SD, Kranz DM, Tanigawa G, Eisen HN, Tonegawa S: Structure, organization, and somatic rearrangement of T cell gamma genes. Cell 40:259–269, 1985

    Google Scholar 

  17. Iwamoto A, Rupp F, Ohashi PS, Walker CL, Pircher H, Joho R, Hengartner H, Mak TW: T cell-specific γ genes in C57BL/10 mice. Sequence and expression of new constant and variable region genes. J Exp Med 163:1203–1212, 1986

    Google Scholar 

  18. Quertermous T, Strauss WM, Van Dongen JJM, Seidman JG: Human T cell γ chain joining regions and T cell development. J Immunol 138:2687–2690, 1987

    Google Scholar 

  19. Chien Y-H, Iwashima M, Kaplan KB, Elliott JF, Davis MM: A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation. Nature 327:677–682, 1987

    Google Scholar 

  20. Satyanarayana K, Hata S, Devlin P, Roncarolo MG, De Vries JE, Spits H, Strominger JL, Krangel MS: Genomic organization of the human T-cell antigen-receptor α/δ locus. Proc Natl Acad Sci USA 85:8166–8170, 1988

    Google Scholar 

  21. Hata S, Clabby M, Devlin P, Spits H, De Vries JE, Krangel MS: Diversity and organization of human T cell receptor δ variable gene segments. J Exp Med 169:41–57, 1989

    Google Scholar 

  22. Takihara Y, Reimann J, Michalopoulos E, Ciccone E, Moretta L, Mak TW: Diversity and structure of human T cell receptor δ chain genes in peripheral blood γ/δ-bearing T lymphocytes. J Exp Med 169:393–405, 1989

    Google Scholar 

  23. Takihara Y, Champagne E, Ciccone E, Moretta L, Minden M, Mak TW: Organization and orientation of a human T cell receptor δ chain V gene segment that suggests an inversion mechanism is utilized in its rearrangement. Eur J Immunol 19:571–574, 1989

    Google Scholar 

  24. Takihara Y, Tkachuk D, Michalopoulos E, Champagne E, Reimann J, Minden M, Mak TW: Sequence and organization of the diversity, joining, and constant region genes of the human T-cell δ-chain locus. Proc Natl Acad Sci USA 85:6097–6101, 1988

    Google Scholar 

  25. Loh EY, Cwirla S, Serafini AT, Phillips JH, Lanier LL: Human T-cell-receptor δ chain: genomic organization, diversity, and expression in populations of cells. Proc Natl Acad Sci USA 85:9714–9718, 1988

    Google Scholar 

  26. Hata S, Satyanarayana K, Devlin P, Band H, McLean J, Strominger JL, Brenner MB, Krangel MS: Extensive junctional diversity of rearranged human T cell receptor δ genes. Science 240:1541–1544, 1988

    Google Scholar 

  27. Loh EY, Elliott JF, Cwirla S, Lanier LL, Davis MM: Polymerase chain reaction with single-sided specificity: Analysis of T cell receptor δ chain. Science 243:217–220, 1989

    Google Scholar 

  28. Yoshikai Y, Clark SP, Taylor S, Sohn U, Wilson BI, Minden MD, Mak TW: Organization and sequences of the variable, joining and constant region genes of the human T-cell receptor α-chain. Nature 316:837–840, 1985

    Google Scholar 

  29. Toyonaga B, Yoshikai Y, Vadasz V, Chin B, Mak TW: Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor β chain. Proc Natl Acad Sci USA 82:8624–8628, 1985

    Google Scholar 

  30. Brenner MB, McLean J, Scheft H, Riberdy J, Ang S-L, Seidman JG, Devlin P, Krangel MS: Two forms of the T-cell receptor γ protein found on peripheral blood cytotoxic T lymphocytes. Nature 325:689–694, 1987

    Google Scholar 

  31. Hochstenbach F, Parker C, McLean J, Gieselmann V, Band H, Bank I, Chess L, Spits H, Strominger JL, Seidman JG, Brenner MB: Characterization of a third form of the human T cell receptor γ/δ. J Exp Med 168:761–776, 1988

    Google Scholar 

  32. Krangel MS, Band H, Hata S, McLean J, Brenner MB: Structurally divergent human T cell receptor γ proteins encoded by distinct Cγ genes. Science 237:64–67, 1987

    Google Scholar 

  33. Hata S, Brenner MB, Krangel MS: Identification of putative human T cell receptor δ complementary DNA clones. Science 238:678–682, 1987

    Google Scholar 

  34. Snodgrass HR, Dembic Z, Steinmetz M, Von Boehmer H: Expression of T-cell antigen receptor genes during fetal development in the thymus. Nature 315:232–233, 1985

    Google Scholar 

  35. Raulet DH, Garman RD, Saito H, Tonegawa S: Developmental regulation of T-cell receptor gene expression. Nature 314:103–107, 1985

    Google Scholar 

  36. Born W, Rathbun G, Tucker P, Marrack P, Kappler J: Synchronized rearrangement of T-cell γ and β chain genes in fetal thymocyte development. Science 234:479–482, 1986

    Google Scholar 

  37. Havran WL, Allison JP: Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors. Nature 335:443–445, 1988

    Google Scholar 

  38. Pardoll DM, Fowlkes BJ, Bluestone JA, Kruisbeek A, Maloy WL, Coligan JE, Schwartz RH: Differential expression of two distinct T-cell receptors during thymocyte development. Nature 326:79–81, 1987

    Google Scholar 

  39. Felix CA, Wright JJ, Poplack DG, Reaman GH, Cole D, Goldman P, Korsmeyer SJ: T cell receptor α-, β-, and γ-genes in T cell and pre-B cell acute lymphoblastic leukemia. J Clin Invest 80:545–556, 1987

    Google Scholar 

  40. Van Dongen JJM, Wolvers-Tettero ILM, Wassenaar F, Borst J, Van den Elsen P: Rearrangement and expression of T-cell receptor delta genes in T-cell acute lymphoblastic leukemias. Blood 74:334–342, 1989

    Google Scholar 

  41. Foroni L, Laffan M, Boehm T, Rabbitts TH, Catovsky D, Luzzatto L: Rearrangement of the T-cell receptor δ genes in human T-cell leukemias. Blood 73:559–565, 1989

    Google Scholar 

  42. Haynes BF, Singer KH, Denning SM, Martin ME: Analysis of expression of CD2, CD3, and T cell antigen receptor molecules during early human fetal thymic development. J Immunol 141:3776–3784, 1988

    Google Scholar 

  43. de Villartay J-P, Hockett RD, Coran D, Korsmeyer SJ, Cohen DI: Deletion of the human T-cell receptor δ-gene by a site-specific recombination. Nature 335:170–174, 1988

    Google Scholar 

  44. Hockett RD, de Villartay J-P, Pollock K, Poplack DG, Cohen DI, Korsmeyer SJ: Human T-cell antigen receptor (TCR) δ-chain locus and elements responsible for its deletion are within the TCR α-chain locus. Proc Natl Acad Sci USA 85:9694–9698, 1988

    Google Scholar 

  45. Winoto A, Baltimore D: Separate lineages of T cells expressing the αβ and γδ receptors. Nature 338:430–432, 1989

    Google Scholar 

  46. Allison JP, Lanier LL: The T-cell antigen receptor gamma gene: Rearrangement and cell lineages. Immunol Today 8:293–296, 1987

    Google Scholar 

  47. Takeshita S, Toda M, Yamagishi H: Excision products of the T cell receptor gene support a progressive rearrangement model of the α/δ locus. EMBO J 8:3261–3270, 1989

    Google Scholar 

  48. Guglielmi P, Davi F, d'Auriol L, Bories J-C, Dausset J, Bensussan A. Use of a variable α region to create a functional T-cell receptor δ chain. Proc Natl Acad Sci USA 85:5634–5638, 1988

    Google Scholar 

  49. Novotny J, Tonegawa S, Saito H, Kranz DM, Eisen HN: Secondary, tertiary, and quaternary structure of T-cell-specific immunoglobulin-like polypeptide chains. Proc Natl Acad Sci USA 83:742–746, 1986

    Google Scholar 

  50. Morley BJ, Chin KN, Newton ME, Weiss A: The lysine residue in the membrane-spanning domain of the β chain is necessary for cell surface expression of the T cell antigen receptor. J Exp Med 168:1971–1978, 1988

    Google Scholar 

  51. John S, Banting GS, Goodfellow PN, Owen MJ: Surface expression of the T cell receptor complex requires charged residues within the α chain transmembrane region. Eur J Immunol 19:335–339, 1989

    Google Scholar 

  52. Hochstenbach F, Brenner MB: T-cell receptor δ-chain can substitute for α to form a βδ heterodimer. Nature 340:562–565, 1989

    Google Scholar 

  53. Koning F, Maloy WL, Cohen D, Coligan JE: Independent association of T cell receptor β and γ chains with CD3 in the same cell. J Exp Med 166:595–600, 1987

    Google Scholar 

  54. Saito T, Hochstenbach F, Marusic-Galesic S, Kruisbeek AM, Brenner M, Germain RN: Surface expression of only γδ and/or αβ T cell receptor heterodimers by cells with four (α,β,γ,δ) functional receptor chains. J Exp Med 168:1003–1020, 1988

    Google Scholar 

  55. De Waal Malefyt R, Alarcon B, Yssel H, Sancho J, Miyajima A, Terhorst CP, Spits H, De Vries JE: Introduction of T cell receptor (TCR)-α cDNA has differential effects on TCR-γδ/CD3 expression by PEER and Lyon-1 cells. J Immunol 142:3634–3642, 1989

    Google Scholar 

  56. Von Boehmer H, Bonneville M, Ishida I, Ryser S, Lincoln G, Smith RT, Kishi H, Scott B, Kisielow P, Tonegawa S: Early expression of a T-cell β-chain transgene suppresses rearrangement of the Vγ4 gene segment. Proc Natl Acad Sci USA 85:9729–9732, 1988

    Google Scholar 

  57. Faure F, Jitsukawa S, Triebel F, Hercend T: Characterization of human peripheral lymphocytes expressing the CD3-γ/δ complex with anti-receptor monoclonal antibodies. J Immunol 141:3357–3360, 1988

    Google Scholar 

  58. Triebel F, Faure F, Graziani M, Jitsukawa S, Lefranc M-P, Hercend T: A unique V-J-C-rearranged gene encodes a γ protein expressed on the majority of CD3+ T cell receptor-α/β− circulating lymphocytes. J Exp Med 167:694–699, 1988

    Google Scholar 

  59. Ciccone E, Ferrini S, Bottino C, Viale O, Prigione I, Pantaleo G, Tambussi G, Moretta A, Moretta L: A monoclonal antibody specific for a common determinant of the human T cell receptor γ/δ directly activates CD3+WT31− lymphocytes to express their functional program(s). J Exp Med 168:1–11, 1988

    Google Scholar 

  60. Triebel F, Faure F, Mami-Chouaib F, Jitsukawa S, Griscelli A, Genevee C, Roman-Roman S, Hercend T: A novel human Vδ gene expressed predominantly in the TiγA fraction of γ/δ+ peripheral lymphocytes. Eur J Immunol 18:2021–2027, 1988

    Google Scholar 

  61. Wu Y-J, Tian W-T, Snider RM, Rittershaus C, Rogers P, LaManna L, Ip SH: Signal transduction of γ/δ T cell antigen receptor with a novel mitogenic anti-δ antibody. J Immunol 141:1476–1479, 1988

    Google Scholar 

  62. Band H, Hochstenbach F, McLean J, Hata S, Krangel MS, Brenner MB: Immunochemical proof that a novel rearranging gene encodes the T cell receptor δ subunit. Science 238:682–684, 1987

    Google Scholar 

  63. Bottino C, Tambussi G, Ferrini S, Ciccone E, Varese P, Mingari MC, Moretta L, Moretta A: Two subsets of human T lymphocytes expressing γ/δ antigen receptor are identifiable by monoclonal antibodies directed to two distinct molecular forms of the receptor. J Exp Med 168:491–505, 1988

    Google Scholar 

  64. Sturm E, Braakman E, Bontrop RE, Chuchana P, Van de Griend RJ, Koning F, Lefranc M-P, Bolhuis RLH: Coordinated Vγ and Vδ gene segment rearrangements in human T cell receptor γ/δ+ lymphocytes. Eur J Immunol 19:1261–1265, 1989

    Google Scholar 

  65. Borst J, Wicherink A, Van Dongen JJM, De Vries E, Comans-Bitter WM, Wassenaar F, Van den Elsen P: Nonrandom expression of T cell receptor γ and δ variable gene segments in functional T lymphocyte clones from human peripheral blood. Eur J Immunol 19:1559–1568, 1989

    Google Scholar 

  66. Jitsukawa S, Triebel F, Faure F, Miossec C, Hercend T: Cloned CD3+ TcR α/β− TiγA− peripheral blood lymphocytes compared to the TiγA+ counterparts: Structural differences of the γ/δ receptor and functional heterogeneity. Eur J Immunol 18:1671–1679, 1988

    Google Scholar 

  67. Groh V, Porcelli S, Fabbi M, Lanier LL, Picker LJ, Anderson T, Warnke RA, Bhan AK, Strominger JL, Brenner MB: Human lymphocytes bearing T cell receptor γ/δ are phenotypically diverse and evenly distributed throughout the lymphoid system. J Exp Med 169:1277–1294, 1989

    Google Scholar 

  68. Koning F, Stingl G, Yokoyama WM, Yamada H, Maloy WL, Tschachler E, Shevach EM, Coligan JE: Identification of a T3-associated γδ T cell receptor on Thy-1+ dendritic epidermal cell lines. Science 236:834–837, 1987

    Google Scholar 

  69. Goodman T, Lefrancois L: Expression of the γ-δ T-cell receptor on intestinal CD8+ intraepithelial lymphocytes. Nature 333:855–858, 1988

    Google Scholar 

  70. Asarnow DM, Goodman T, LeFrancois L, Allison JP: Distinct antigen receptor repertoires of two classes of murine epithelium-associated T cells. Nature 341:60–62, 1989

    Google Scholar 

  71. Bonneville M, Janeway Jr CA, Ito K, Haser W, Ishida I, Nakanishi N, Tonegawa S: Intestinal intraepithelial lymphocytes are a distinct set of γδ T cells. Nature 336:479–481, 1988

    Google Scholar 

  72. Bucy RP, Chen C-LH, Cooper MD: Tissue localization and CD8 accessory molecule expression of Tγδ cells in humans. J Immunol 142:3045–3049, 1989

    Google Scholar 

  73. Solomon KR, Krangel MS, McLean J, Brenner MB, Band H: Human T cell receptor γ and δ chain pairing analyzed by transfection of a T cell receptor δ negative mutant cell line. J Immunol (in press), 1990

  74. Triebel F, Lefranc M-P, Hercend T: Further evidence for a sequentially ordered activation of T cell rearranging gamma genes during T lymphocyte differentiation. Eur J Immunol 18:789–794, 1988

    Google Scholar 

  75. Yancopoulos GD, Desiderio SV, Paskind M, Kearney JF, Baltimore D, Alt FW: Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature 311:727–733, 1984

    Google Scholar 

  76. Perlmutter RM, Kearney JF, Chang SP, Hood LE: Developmentally controlled expression of immunoglobulin VH genes. Science 227:1597–1601, 1985

    Google Scholar 

  77. Patel SS, Wacholtz MC, Duby AD, Thiele DL, Lipsky PE: Analysis of the functional capabilities of CD3+CD4−CD8− and CD3+CD4+CD8+ human T cell clones. J Immunol 143:1108–1117, 1989

    Google Scholar 

  78. Borst J, Van de Griend RJ, Van Oostveen JW, Ang S-L, Melief CJ, Seidman JG, Bolhuis RLH: A T-cell receptor γ/CD3 complex found on cloned functional lymphocytes. Nature 325:683–688, 1987

    Google Scholar 

  79. Bluestone JA, Cron RQ, Cotterman M, Houlden BA, Matis LA: Structure and specificity of T cell receptor γ/δ on major histocompatibility complex antigen-specific CD3+, CD4−, CD8− T lymphocytes. J Exp Med 168:1899–1916, 1988

    Google Scholar 

  80. Kozbor D, Trinchieri G, Monos DS, Isobe M, Russo G, Haney JA, Zmijewski C, Croce CM: Human TCR-γ+/δ+, CD8+ T lymphocytes recognize tetanus toxoid in an MHC-restricted fashion. J Exp Med 169:1847–1851, 1989

    Google Scholar 

  81. Matis LA, Cron R, Bluestone JA: Major histocompatibility complex-linked specificity of γδ receptor-bearing T lymphocytes. Nature 330:262–264, 1987

    Google Scholar 

  82. Vidovic D, Roglic M, McKune K, Guerder S, MacKay C, Dembic Z: Qa-1 restricted recognition of foreign antigen by a γδ T-cell hybridoma. Nature 340:646–649, 1989

    Google Scholar 

  83. Porcelli S, Brenner MB, Greenstein JL, Balk SP, Terhorst C, Bleicher PA: Recognition of cluster of differentiation 1 antigens by human CD4−CD8− cytolytic T lymphocytes. Nature 341:447–450, 1989

    Google Scholar 

  84. Lanier LL, Weiss A: Presence of Ti (WT31) negative T lymphocytes in normal blood and thymus. Nature 324:268–270, 1986

    Google Scholar 

  85. Terry LA, DiSanto JP, Small TN, Flomenberg N: Differential expression of the CD8 and Lyt-3 antigens on a subset of human γ-δ T-cell receptor bearing T lymphocytes. FASEB J 3:A807, Abstr 3377, 1989

  86. Grossi CE, Ciccone E, Migone N, Bottino C, Zarcone D, Mingari MC, Ferrini S, Tambussi G, Viale O, Casorati G, Millo R, Moretta L, Moretta A: Human T cells expressing the γ/δ T-cell receptor (TcR-1): Cγ1- and Cγ2-encoded forms of the receptor correlate with distinctive morphology, cytoskeletal organization, and growth characteristics. Proc Natl Acad Sci USA 86:1619–1623, 1989

    Google Scholar 

  87. Spencer J, Isaacson PG, Diss TC, MacDonald TT: Expression of disulfide-linked and non-disulfide-linked forms of the T cell receptor γ/δ heterodimer in human intestinal intraepithelial lymphocytes. Eur J Immunol 19:1335–1338, 1989

    Google Scholar 

  88. Holoshitz J, Koning F, Coligan JE, De Bruyn J, Strober S: Isolation of CD4− CD8− mycobacteria-reactive T lymphocyte clones from rheumatoid arthritis synovial fluid. Nature 339:226–229, 1989

    Google Scholar 

  89. Modlin RL, Pirmez C, Hofman FM, Torigian V, Uyemura K, Rea TH, Bloom BR, Brenner MB: Lymphocytes bearing antigen-specific γδ T-cell receptors accumulate in human infectious disease lesions. Nature 339:544–548, 1989

    Google Scholar 

  90. Haregewoin A, Soman G, Hom RC, Finberg RW: Human γδ+ T cells respond to mycobacterial heat-shock protein. Nature 340:309–312, 1989

    Google Scholar 

  91. O'Brien RL, Happ MP, Dallas A, Palmer E, Kubo R, Born WK: Stimulation of a major subset of lymphocytes expressing T cell receptor γδ by an antigen derived fromMycobacterium tuberculosis. Cell 57:667–674, 1989

    Google Scholar 

  92. Janis EM, Kaufmann SHE, Schwartz RH, Pardoll DM: Activation of γδ T cells in the primary immune response toMycobacterium tuberculosis. Science 244:713–716, 1989

    Google Scholar 

  93. Augustin A, Kubo RT, Sim G-K: Resident pulmonary lymphocytes expressing the γ/δ T-cell receptor. Nature 340:239–241, 1989

    Google Scholar 

  94. Toyonaga B, Mak TW: Genes of the T-cell antigen receptor in normal and malignant T cells. Ann Rev Immunol 5:585–620, 1987

    Google Scholar 

  95. Cantrell DA, Davies AA, Crumpton MJ: Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes. Proc Natl Acad Sci USA 82:8158–8162, 1985

    Google Scholar 

  96. Sleckman BP, Bigby M, Greenstein JL, Burakoff SJ, Sy M-S: Requirements for modulation of the CD4 molecule in response to phorbol myristate acetate. Role of the cytoplasmic domain. J Immunol 142:1457–1462, 1989

    Google Scholar 

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    Frans Hochstenbach & Michael B. Brenner

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Hochstenbach, F., Brenner, M.B. Newly identified γδ and βδ T-cell receptors. J Clin Immunol 10, 1–18 (1990). https://doi.org/10.1007/BF00917493

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