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The structural and functional heterogeneity of glutamic acid decarboxylase: A review

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Abstract

Studies of the GABA-synthetic enzyme glutamate decarboxylase (glutamic acid decarboxylase; GAD; E.C.4.1.1.15) began in 1951 with the work of Roberts and his colleagues. Since then, many investigators have demonstrated the structural and functional heterogeneity of brain GAD. At least part of this heterogeneity derives from the existence of two GAD genes.

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Authors and Affiliations

  1. Neuroscience Program, University of California, Los Angeles, 90024, Los Angeles, California

    Mark G. Erlander

  2. Department of Biology, University of California, Los Angeles, 90024-1606, Los Angeles, California

    Allan J. Tobin

  3. Molecular Biology Institute, University of California, Los Angeles, 90024, Los Angeles, California

    Allan J. Tobin

  4. Brain Research Institute, University of California, Los Angeles, 90024, Los Angeles, California

    Allan J. Tobin

  5. The Department of Biology, University of California, Los Angeles, 90024-1606, Los Angeles, CA

    Allan J. Tobin

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  1. Mark G. Erlander
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  2. Allan J. Tobin
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In honor of the 70th birthday of Dr. Eugene Roberts

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Erlander, M.G., Tobin, A.J. The structural and functional heterogeneity of glutamic acid decarboxylase: A review. Neurochem Res 16, 215–226 (1991). https://doi.org/10.1007/BF00966084

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