Abstract
Normal protein-boundl-aspartyl/l-asparaginyl residues may undergo post-translational modification by racemization tod-aspartate, or by isomerization to thel-isoaspartyl form in which the peptide chain links through the beta carboxyl group of the residue. Based on preliminary results reported here, proteins associated with Alzheimer neurofibrillary tangle preparations contain a significantly greater number of these modified aspartyl residues than the unaffected proteins from the surrounding gray matter or in comparable preparations from normal brains.
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Payan, I.L., Chou, SJ., Fisher, G.H. et al. Altered aspartate in Alzheimer neurofibrillary tangles. Neurochem Res 17, 187–191 (1992). https://doi.org/10.1007/BF00966798
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DOI: https://doi.org/10.1007/BF00966798