Summary
Plasma corticosterone concentrations in diabetic (db) mice maintained on two different inbred backgrounds were found to be elevated significantly when compared to normal controls. These data are similar to that reported with the phenotypically similar obese (ob) mouse. These results suggest that the hyperadrenolcorticism is not related to the primary gene action of either gene but rather is a consequence of the development of the obesity-diabetes syndromes.
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Supported in part by NIH Research grants AM 14461 from the National Institute of Arthritis, Metabolism, and Digestive Diseases and HD 05523 from the National Institute of Child Health and Human Development. The Jackson Laboratory is fully accredited by the American Association for the Accreditation of Laboratory Animal Care
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Coleman, D.L., Burkart, D.L. Plasma corticosterone concentrations in diabetic (db) mice. Diabetologia 13, 25–26 (1977). https://doi.org/10.1007/BF00996323
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DOI: https://doi.org/10.1007/BF00996323