Abstract
UrinaryΒ 2-microglobulin (MG) was determined in 99 elderly people above 50 years of age from an area with no known cadmium pollution. With advancing age, the urinary MG increased as well as the urinary protein, urinary retinol-binding protein (RBP), and plasma urea nitrogen. Nevertheless, age effects were not observed in renal functions such as creatinine clearance or tubular reabsorption of phosphorus. Analysis of the relationship between urinary MG and parameters of the renal functions suggested 2-step increases in urinary MG: a slight increase between 160 and 1600Μg/L and a remarkable increase above 1600Μg/L. The latter strong increase in urinary MG was closely related with depressed tubular reabsorption of MG, but was independent of tubular reabsorption of phosphorus. The screening level of urinary MG for renal tubular dysfunction is suggested at 1600Μg/L.
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Nomiyama, K., Yotoriyama, M. & Nomiyama, H. Urinaryβ 2-microglobulin and renal functions in elderly people in an area with no known cadmium pollution (Japan). Arch. Environ. Contam. Toxicol. 12, 143–146 (1983). https://doi.org/10.1007/BF01059572
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DOI: https://doi.org/10.1007/BF01059572