References
Campbell, B. A., Lytle, L. D., and Fibiger, H. C. (1969). Ontogeny of adrenergic arousal and cholinergic inhibitory mechanisms in the rat.Science 166:635–637.
Coyle, J. T., and Yamamura, H. I. (1976). Neurochemical aspects of ontogenesis of cholinergic neurons in the rat brain.Brain Res. 118:429–440.
Crocker, A. D., and Overstreet, D. H. (1990). Changes in dopamine sensitivity in rats selectively bred for differences in cholinergic function.Pharmacol. Biochem. Behav. (in press).
Daws, L. C., Schiller, G. D., Overstreet, D. H., and Orbach, J. (1990). Early development of muscarinic supersensitivity in a genetic animal model of depression.Neuropsychopharmacology (in press).
Gallaher, D. W., and Gionet, S. (1990). Dissociation of ataxic and anti-convulsant effects of a diazepam in DS and DR mice suggests different underlying mechanisms. Presented at 20th meeting of Behavior Genetics Association, France, June 6–9.
Janowsky, D. S., and Risch, S. C. (1987). Role of actetylcholine mechanisms in affective disorders. In Meltzer, H. Y. (ed.),Psychopharmacology. The Third Generation of Progress, Raven Press, New York, pp. 527–534.
Mendlewicz, J., Kerkhofs, M., Hoffmann, G., and Linkowski, P. (1984). Dexamethasone suppression test and REM sleep in patients with major depressive disorder.Br. J. Psychiat. 145:383–388.
Nurnberger, J. I., Jr. Jimerson, D. C., Simmons-Alling, S., Tamminga, C., Nadi, N. S., Lawrence, D., Sitaram, N., Gillin, J. C., and Gershon, E. S. (1983). Behavioral, physiological and neuro-endocrine response to arecoline in normal twins and well state bipolar patients.Psychiat. Res. 9:191–202.
Overstreet, D. H. (1986). Selective breeding for increased cholinergic function: Development of a new animal model of depression.Biol. Psychiat. 21:49–58.
Overstreet, D. H., and Russell, R. W. (1982). Selective breeding for sensitivity to DFP. Effects of cholinergic agonists and antagonists.Psychopharmacology 78:150–155.
Overstreet, D. H., and Russell, R. W. (1984). Selective breeding for differences in cholinergic function: Sex differences in the genetic regulation of sensitivity to the anticholinesterase, DFP.Behav. Neural Biol. 40:227–238.
Overstreet, D. H., Russell, R. W., Crocker, A. D., and Schiller, G. D. (1984). Selective breeding for differences in cholinergic function: Pre- and post-synaptic mechanisms involved in sensitivity to the anticholinesterase, DFP.Brain Res. 294:327–332.
Overstreet, D. H., Russell, R. W., Crocker, A. D., Gillin, J. C., and Janowsky, D. S. (1988). Genetic and pharmacological models of cholinergic supersensitivity and affective disorders.Experientia 44:465–472.
Overstreet, D. H., Double, K., and Schiller, G. D. (1989). Antidepressant effects of rolipram in a genetic animal model of depression: Cholinergic supersensitivity and weight gain.Pharmacol. Biochem. Behav. 34:691–696.
Pepe, S., Overstreet, D. H., and Crocker, A. D. (1988). Enhanced benzodiazepine responsiveness in rats with increased cholinergic function.Pharmacol. Biochem. Behav. 31:15–20.
Russell, R. W., and Overstreet, D. H. (1987). Mechanisms underlying sensitivity to organophosphorus anticholinesterase agents.Prog. Neurobiol. 28:97–129.
Schiller, G. D., Orbach, J., and Overstreet, D. H. (1988). Effects of intracerebroventricular administration of site-selective muscarinic drugs in rats genetically selected for differing cholinergic sensitivity. Presented at meeting of Australasian Society of Clinical and Experimental Pharmacology, Adelaide, December.
Shiromani, P. J., Gillin, J. C., and Hendrickson, P. (1987). Acetylcholine and the regulation of REM sleep—Basic mechanisms and clinical implications for affective illness and narcolepsy.Annu. Rev. Pharmacol. Toxicol. 27:137–156.
Shiromani, P. J., Overstreet, D. H., Levy, D., Goodrich, C. A., Campbell, S. S., and Gillin, J. C. (1988). Increased REM sleep in rats selectively bred for cholinergic hyperactivity.Neuropsychopharmacology 1:127–133.
Sitaram, N., Dube, S., Jones, D., Pohl, R., and Gershon, S. (1984). Acetylcholine and alphal-adrenergic sensitivity in the separation of depression and anxiety.Psychopathology 17 (Suppl. 3):24–39.
Sitaram, N., Dube, S., Keshavan, M., Davies, A., and Reynal, P. (1987). The association of supersensitive cholinergic REM-induction and affective illness within pedigrees.J. Psychiat. Res. 21:487–497.
Wallis, E., Overstreet, D. H., and Crocker, A. D. (1988). Selective breeding for increased cholinergic function: Increased serotonergic sensitivity.Pharmacol. Biochem. Behav. 31:345–350.
Weissman, M. M., Gammon, G. D., John, K., Merikangas, K. R., Warner, V., Prusoff, B. A., and Sholonski, D. (1987). Children of depressed parents.Arch. Gen. Psychiat. 44:847–853.
Wolff, E. A., III, Putnam, F. W., and Post, R. M., (1985) Motor activity and affective illness. The relationship of amplitude and temporal distribution to changes in affective state.Arch. Gen. Psychiat. 42:288–294.
Author information
Authors and Affiliations
Additional information
This work was reported in part by research gives from the National Health and Medicine Research Council (Australia), the Australian Research Council, and the Flinders University Research Budget.
This commentary derives from a presentation made at a workshop on “Genetic Aspects of Anxiety/Depression in Humans and Rats: Nature of the Syndrome(s) and Veracity of the Model(s),” which was held during the 20th annual BGA meeting, June 1990, in Aussois, France.
Rights and permissions
About this article
Cite this article
Overstreet, D.H. Commentary: A behavioral, psychopharmacological, and neurochemical update on the flinders sensitive line rat, a potential genetic animal model of depression. Behav Genet 21, 67–74 (1991). https://doi.org/10.1007/BF01067667
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01067667