References
Fingl E: Laxatives and cathartics. The Pharmacological Basis of Therapeutics. L S Goodman, A Gilman (eds). New York, The MacMillan Co, 1975, pp 976–986
Bonnycastle D: Cathartics and laxatives. Drill's Pharmacology in Medicine. J R DiPalma (ed). New York, McGraw-Hill, 1971, pp 975–991
Meyer H: Ueber den wirksamen bestandtheil des ricinusols. Arch Exp Path Pharmak 28:145–152, 1890
James AT, Webb JPW, Kellock TD: The occurrence of unusual fatty acids in fecal lipids from human beings with normal and abnormal fat absorption. Biochem J 78:333–339, 1961
Webb JPW, James AT, Kellock TD: The influence of diet on the quality of fecal fat in patients with and without steatorrhoea. Gut 4:37–41, 1963
Thomas PJ: Identification of some enteric bacteria which convert oleic acid to hydroxystearic acid in vitro. Gastroenterology 62:430–435, 1972
Kim YS, Spritz N: Metabolism of hydroxy fatty acids in dogs with steatorrhea secondary to experimetnally produced intestinal blind loops. J Lipid Res 9:487–491, 1968
Ammon HV, Thomas PJ, Phillips SF: Effects of oleic and ricinoleic acids on net jejunal water and electrolyte movement. J Clin Invest 53:374–379, 1974
Ammon HV, Phillips SF: Inhibition of ileal water absorption by intraluminal fatty acids. J Clin Invest 53:205–210, 1974
Ammon HV, Phillips SF: Inhibition of colonic water and electrolyte absorption by fatty acids in man. Gastroenterology 65:744–749, 1973
Bright-Asare P, Binder HJ: Stimulation of colonic secretion of water and electrolytes by hydroxy fatty acids. Gastroenterology 64:81–88, 1973
Stewart JJ, Gaginella TS, Bass P: Inhibitory actions of laxatives on motility and water and electrolyte transport in the gastrointestinal tract. J Pharm Exp Ther 192:458–467, 1975
Gaginella TS: Mechanism and structure-activity relationships for fatty acid induced inhibition of fluid transport by the hamster small intestine in vitro. Madison, Wisconsin, Doctoral Dissertation, 1974, pp 207
Gaginella TS, Stewart JJ, Bass P: The ability of sodium ricinoleate to inhibit water transport and smooth muscle contractility in vitro. Gastroenterology 66:840, 1974
Christensen J, Weisbrodt NW, Hauser RL: Electrical slow wave of proximal colon of the cat in diarrhea. Gastroenterology 62:1167–1173, 1972
Christensen J, Freeman BW: Circular muscle electromyogram in the cat colon: Local effect of sodium ricinoleate. Gastroenterology 63:1011–1015, 1972
Gregory J: The modus operandi of oleum ricini. What diseases is it useful? Dissertations by eminent members of the Royal Medical College, Edinburgh, 1892, pp 9–14
Fluckiger FA, Hanbury D, Semen R: Pharmacographia. A history of the principle drugs of vegetable origin, met with in Great Britain and British India. Second ed. London, MacMillan and Co, 1879, pp 567–571
Sigerist HE: A history of medicine. Primitive and Archaic Medicine, Vol. 1. New York, Oxford University Press, 1951, pp 341–350
Badianus J. Cruz M: The Badianus Manuscript. An Aztec Herbal of 1552. Translated by EW Emmart. Baltimore, Johns Hopkins Press, 1940
Culpeper N: A Physical Directory: or a Translation of the Dispensatory Made by the Colledg of Physitian of London. London, 1651, pp 162–167
Salmon W: The New London Dispensatory. Third Ed. London, 1685, pp 84–85
Hill J: A History of the Materia Medica. London, 1751, pp 537–541
Fraser T: An account of the oleum ricini, commonly called castor oil, and its effects as a medicine, especially in bilius disorders. Medical Observations and Inquiries. Vol. 2. London, 1762, pp 235–240
LaWall H: Four Thousand Years of Pharmacy. Philadelphia and London, J B Lippincott Co, 1927, p 428
Lewis W: The Edinburgh New Dispensatory. Edinburgh, 1797, 225
Thacher J: Ricinus Communis. The American New Dispensatory. T B Wait (publisher). Boston, 1821, pp 349–350
Eberle J: A Treatise of the Materia Medica and Therapeutics. Sixth Ed. Philadelphia, Grigg, Elliot and Co, 1847. Ch. III. Cathartics pp 83–87 Casor Oil pp 129–131
Hester A: Note on castor oil. New Orleans Med and Surg J 12:164–166, 1855
Pomet P: A Compleat History of Drugs. Vol. 1. London, 1712, pp 145–146
Scott G: Ointments and babies. Brit Med J 1:1541–1542, 1966
Stuart GA: Chinese Materia Medica, Vegetable Kingdom. Shanghai, AM Presbyterian Mission Press, 1911, pp 378–379
MacPhee GG: Castor oil vapour as a purgative. Brit Med J 2:1045, 1934
Bussy A, Lecanu LR: Sur l'huile de ricin. J de Pharmacie et de Chimie 13:57–81, 1827
Saalmüller L: Ueber die fetten Sauren des Ricinusols. Annalen Der Chemie und Pharmacie 64:108–126, 1848
Dixson T: On the active principle of castor oil. Med Chir Trans 70:107–116, 1887
Binder RG, Applewhite TH, Kohler GO, Goldblatt LA: Chromatographic analysis of seed oils. Fatty acid composition of castor oil. J Am Oil Chem Soc 39:513–17, 1962
Vallette G, Salvanet R: Sur l'absorption intestinale de l'huile de Ricin. Bull Soc Chem Biol 18:911–917, 1936
Paul H, McCay CM: The utilization of fats by herbivora. Arch Biochem 1:247–253, 1943
Iwao I, Terada Y: On the mechanism of diarrhea due to castor oil. Jap J Pharmacol 12:137–145, 1962
Reynell PC, Spray GH: Chemical gastroenteritis in the rat. Gastroenterology 34:867–873, 1958
Watson WC, Gordon RS Jr, Karmen A, Jover A: The absorption and excretion of castor oil in man. J Pharm Pharmac 15:183–188, 1963
Watson WC, Gordon RS Jr: Studies on the digestion, absorption and metabolism of castor oil. Biochem Pharmacol 11:229–236, 1962
Stewart WC, Sinclair RG: The absence of ricinoleic acid from phospholipids of rats fed castor oil. Arch Biochem 8:7–11, 1945
Soong CS, Thompson JB, Poley JR, Hess DR: Hydroxy fatty acids in human diarrhea. Gastroenterology 63:748–757, 1972
Hofmann AF, Poley JR: Role of bile acid malabsorption in pathogenesis of diarrhea and steatorrhea in patients with ileal resection. I. Response to cholestryramine or replacement of dietary long-chain triglyceride by medium-chain triglyceride. Gastroenterology 62:918–934, 1972
Mekhjian HS, Phillips SF, Hofmann AF: Colonic secretion of water and electrolytes induced by bile acids: Perfusion studies in man. J Clin Invest 50:1569–1577, 1971
Wingate DL, Phillips SF, Hofmann AF: Effect of glycine-conjugated bile acids with and without lecithin on water and glucose absorption in perfused human jejunum. J Clin Invest 52:1230–1236, 1973
Teem MV, Phillips SF: Perfusion of the hamster jejunum with conjugated and unconjugated bile acids: Inhibition of water absorption and effects on morphology. Gastroenterology 62:261–267, 1972
Mlkhjian HS, Phillips SF: Perfusion of the canine colon with unconjugated bile acids. Gastroenterology 59:120–129, 1970
Curran PR, Macintosh JR: A model system for biological water transport. Nature 193:347–348, 1962
Schultz SG, Frizzell RA, Nellans HN: Ion transport by mammalian small intestine Rev Physiol 36:51–91, 1974
Parsons DS: Salt and water absorption by the intestinal tract. Br Med Bull 23:252–257, 1967
Phillips RA, Love AHG, Mitchell TG, Neptune EM: Cathartics and the sodium pump. Nature 206:1367–1368, 1965
Ahmed K, Thomas BS: The effects of long-chain fatty acids on sodium plus potassium ion-stimulated adenosine triphosphatase of rat brain. J Biol Chem 246:103–109, 1974
Borst P, Loos JA, Christ EJ, Slater EC: Uncoupling activity of long-chain fatty acids. Biochim Biophys Acta 62:509–518, 1962
Wojtczak L, Zaluska H: The inhibition of translocation of adenine nucleotides through mitochondrial membranes by oleate. Biochem Biophys Res Comm 28:76–81, 1967
Shrago E, Shug A, Elson C, Lerner E: Regulation of the translocation of adenine nucleotides across the inner mitochondrial membrane by long-chain acyl CoA esters. Symposium on metabolic regulation. The Role of Membranes in Metabolic Regulations. MA Mehlman, RW Hanson (eds). Academic Press, 1972
Vaartjes WJ, Kemp A Jr, Souverijn JHM, Van Den Bergh SG: Inhibition by fatty acyl esters of adenine nucleotide translocation in rat liver mitochondria. FEBS Lett 23:303–308, 1972
Gaginella TS, Bass P, Olsen W, Shug A: Fatty acid inhibition of water absorption and energy production in the hamster jejunum. FEB Lett 53:347–350, 1975
Field M: Intestinal secretion. Gastroenterology 66:1063–1084, 1974
Kimberg DV: Cyclic nucleotides and their role in gastrointestinal secretion. Gastroenterology 67:1027–1064, 1974
Field M: Intestinal secretion: Effect of cyclic AMP and its role in cholera. N Eng J Med 284:1137–1144, 1971
Banwell JG, Sherr H: Effects of bacterial enterotoxins on the gastrointestinal tract. Gastroenterology 65:467–497, 1973
Binder HJ: Fecal fatty acids—mediators of diarrhea? (editorial) Gastroenterology 65:847–850, 1973
Stewart JJ. Gaginella TS, Bass P: Actions of ricinoleic acid and structurally related fatty acids on the gastrointestinal tract. I. Effects on smooth muscle contractile activity in vitro. J Pharmacol Exp Ther, in press
Gaginella TS, Stewart JJ, Olsen WA, Bass P: Actions of ricinoleic acid and structurally related fatty acids on the gastrointestinal tract. II. Effects on water and electrolyte transportin vitro. J Pharmacol Exp Ther, in press
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Part of this material comes from a Doctoral Thesis completed at the University of Wisconsin under the direction of Dr. Paul Bass.
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Gaginella, T.S., Phillips, S.F. Ricinoleic acid: Current view of an ancient oil. Digest Dis Sci 20, 1171–1177 (1975). https://doi.org/10.1007/BF01070759
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DOI: https://doi.org/10.1007/BF01070759