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Cell wall fractions fromParacoccidioides brasiliensis induce hypergammaglobulinemia

  • Human And Animal Mycolocy
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Abstract

The antibody response against the antigen sheep red blood cells (SRBC) was investigated in mice pre-treated with formalin-killedParacoccidioides brasiliensis or with cell wall fractions of the fungus. Pre-treatment withP. brasiliensis, as well as with the F1 fraction and beta-glucan significantly increased the anti-SRBC antibody response in the experimental groups as compared to the control group that received only SRBC. This immunomodulatory effect varied with the different doses employed and with pre-treatment time. We conclude that the cell wall fractions ofP. brasiliensis might play an important role in the hypergammaglobulinemia associated with Paracoccidioidomycosis.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, UNESP, Botucatu, SP

    Silvio Luis de Oliveira, Marcelo Fernandes da Silva & Angela Maria Victoriano de Campos Soares

  2. Department of Parasitology, Microbiology and Immunology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 -900, Ribeirao Preto, SP, Brazil

    Celio Lopes Silva

Authors
  1. Silvio Luis de Oliveira
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  2. Marcelo Fernandes da Silva
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  3. Angela Maria Victoriano de Campos Soares
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  4. Celio Lopes Silva
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de Oliveira, S.L., da Silva, M.F., Victoriano de Campos Soares, A.M. et al. Cell wall fractions fromParacoccidioides brasiliensis induce hypergammaglobulinemia. Mycopathologia 121, 1–5 (1993). https://doi.org/10.1007/BF01103346

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  • DOI: https://doi.org/10.1007/BF01103346

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