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Fundus pigmentation and the electroretinographic luminance-response function

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Abstract

Dark-adapted and light-adapted electroretinogaphic luninance-response functions were recorded from subjects with light or dark fundus pigmentation based on digitized fundus photographs. For dark- and light-adapted electroretinograms, subjects with dark fundi had smaller b-wave amplitudes at all luminance levels. There was no significant difference in b-wave implicit time for the dark-adapted electroretinogram, but there was a significant difference for the light-adapted ERG between the two groups. The results suggest that fundus pigmentation should be considered in the interpretation of electroretinogram results. A possible mechanism for the influence of fundus pigmentation on b-wave amplitude is based on increased resistance associated with melanin.

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Abbreviations

ISI:

interstimulus interval

L-R function:

luminance-response function

ND:

neutral density

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Authors and Affiliations

  1. Department of Ophthalmology, Columbus Children's Hospital, 700 Children's Drive, 43205, Columbus, OH, USA

    Naheed Wali & Lawrence E. Leguire

Authors
  1. Naheed Wali
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  2. Lawrence E. Leguire
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Wali, N., Leguire, L.E. Fundus pigmentation and the electroretinographic luminance-response function. Doc Ophthalmol 84, 61–69 (1993). https://doi.org/10.1007/BF01203283

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