Abstract
Twenty-one macroaneurysms and related vessels of 19 patients were evaluated morphometrically. Macroaneurysms were classified into two groups as hemorrhagic and exudative in terms of their major clinical sign. Average diameters of the macroaneurysms were arranged in a Gaussian distribution curve (mean and standard deviation: 281.60 ± 57.28 micrometers). Regarding the distribution curve based on this data macroaneurysm can be defined as being greater than 109.76 micrometers. Macroaneurysms were most frequent on the superotemporal vessels (52.38%), followed by the inferotemporal (38.10%), inferonasal (4.76%) and superonasal vessels. Average diameter (r=+0.68, p=0.0006) and area (r=+0.71, p=0.0003) of the macroaneurysms were significantly correlated to the diameter of the relevant arterial segments. The distribution of the macroaneurysms in respect to arterial bifurcation (X 2=18.762, p=0.0003) and arteriovenous crossings (X 2=8.286, p=0.0405) were nonrandom with macroaneurysms clustering near this points. Hemorrhagic macroaneurysms were significantly closer to the optic disc (p<0.01) and were located on relatively larger arterioles (p<0.01). They were also more circular (p<0.01) in shape and greater in area (p<0.01) and diameter (p<0.01) than the exudative ones. These findings suggest that the location of the macroaneurysm is closely related to its clinical appearance.
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References
Robertson DM. Macroaneurysms of the retinal arteries. Ophthalmology (Rochester) 1973; 77: 55–67.
Badii G, Messmer EP. Spontanregression bei erworbenem arteriellen Makroaneurysma der Retina. Klin Mbl Augenheilk 1992; 200: 537–8.
Abdel-Khalek MN, Richardson J. Retinal Macroaneurysm: natural history and guidelines for treatment. Br J Ophthalmol 1986; 70: 2–11.
Noble KG. Retinalmacroaneurysms. Ophthalmology 1984; 91: 108–9.
Lavin MJ, Marsh RJ, Peart S, Rehman A. Retinal macroaneurysms: a retrospective study of 40 patients. Br J Ophthalmol 1987; 71: 817–25.
O'Shea D. Elements of modern optical design. New York: John Wiley and Sons, 1987: 192.
Pomerantzeff O, Webb RH, Delori FC. Image formation in fundus cameras.Invest Ophthalmol Vis Sci 1979; 18: 630–7.
Littmann H. Zur Bestimmung der wahren Grösse eines Objektes auf dem Hintergrund des lebenden Auges. Klin Mbl Augenheilk 1988; 192: 66–7.
Wise G, Dollery C, Henkind P. The retinal circulation. New York: Harper & Row, 1971: 278–84.
Feke GT, Tagawa H, Deupree DM, Goger DG, Sebag L, Weiter JJ. Blood flow in normal human retina. Invest Ophthalmol Vis Sci 1989; 30: 58–65.
Iwasawa A, Majima A, Shirai S, Taki M. Bilateral prepapillary macroaneurysm. Report of a case. Jap J Clin Ophthal 1989; 43: 619–23.
Perktold K, Peter R, Resch M. Pulsatile non-newtonian blood flow simultion through a bifurcation with an aneurysm. Biorheology 1989; 26: 1011–30.
Fichte C, Streeten BW, Friedman AH. A histopathologic study retinal arterial aneurysms. Am J Ophthalmol 1978; 85: 509–18.
Weinberg DV, Egan KM, Seddon JM. Asymmetric distribution of arteriovenous crossings in the normal retina. Ophthalmology 1993; 100: 31–36.
Schröder S, Schmid-Schönbein GW, Schmid-Schönbein H, Brab M, Reim M. Methodezur Erfassung der Netzwerktopologie der menschlichen Retinagefasse. Klin Mbl Augenheilk 1990; 197: 33–39.
Mainster MA. The fractal properties of retinal vessels: embryological and clinical implications. Eye 1990; 4: 235–241.
Palestine AG, Robertson DM, Goldstein BG. Macroaneurysms of the retinal arteries. Am J Ophthalmol 1982; 93: 164–71.
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Tezel, T., Günalp, I. & Tezel, G. Morphometrical analysis of retinal arterial macroaneurysms. Doc Ophthalmol 88, 113–125 (1994). https://doi.org/10.1007/BF01204609
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DOI: https://doi.org/10.1007/BF01204609