Abstract
The results of radiotherapy combined with hyperbaric oxygen in 9 patients with malignant glioma were compared with those of radiotherapy without hyperbaric O2 in 12 patients. This is the first report of a pilot study of irradiation immediately after exposure to hyperbaric O2 in humans. All patients receiving this treatment showed more than 50% regression of the tumor, and in 4 of them, the tumors disappeared completely. Only 4 out of 12 patients without hyperbaric O2 showed decreases in tumor size, and all 12 patients died within 36 months. So far, this new regimen seems to be a useful form of radiotherapy for malignant gliomas.
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References
Chang CH (1977) Hyperbaric oxygen and radiation therapy in the management of glioblastoma. Natl Cancer Inst Monogr 46:163–169
Dowling S, Fischer JJ, Rockwell S (1992) Fluosol and hyperbaric oxygen as an adjunct to radiation therapy in the treatment of malignant gliomas: a pilot study. Biomater Artif Cells Immobilization Biotechnol 20:903–905
Gaspar LE, Fisher BJ, Macdonald DR, LeBer DV, Halperin EC, Schold SC, Cairncross JG (1993) Malignant glioma — timing of response to radiation therapy. Int J Radiat Oncol Biol Phys 25:877–879
Groshar D, McEwan AJB, Parliament MB, Urtasun RC, Golberg LE, Hoskinson M, Mercer JR, Mannan RH, Wiebe LI, Chapman JD (1993) Imaging tumor hypoxia and tumor perfusion. J Nucl Med 34:885–888
Hall EJ (1994) Radiobiology for the radiologist, 4th edn. Lippincott, Philadelphia, pp 133–152
Jain KK (1990) Textbook of hyperbaric medicine. Hogrefe & Huber, Toronto, pp 408–417
Takakura K, Abe H, Tanaka R, Kitamura K, Miwa T, Takeuchi K, Yamamoto S, Kageyama N, Handa H, Mogami H, Nishimoto A, Uozumi T, Matsutani M, Nomura K (1986) Effects of ACNU and radiotherapy on malignant glioma. J Neurosurg 64:53–57
Tyler JL, Diksic M, Villemure J-G, Evans AC, Meyer E, Yamamoto YL, Feindel W (1987) Metabolic and hemodynamic evaluation of gliomas using positron emission tomography. J Nucl Med 28:1123–1133
Wells CH, Goodpasture JE, Horrigan DJ, Hart GB (1977) Tissue gas measurements during hyperbaric oxygen exposure. In: Smith G (ed) Proceedings of the 6th International Congress on Hyperbaric Medicine. Aberdeen University Press. Aberdeen, pp 118–124
Wood JR, Green SB, Shapiro WR (1988) The prognostic importance of tumor size in malignant gliomas: a computed tomographic scan study by the Brain Tumor Cooperative Group. J Clin Oncol 6:338–343
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Kohshi, K., Kinoshita, Y., Terashima, H. et al. Radiotherapy after hyperbaric oxygenation for malignant gliomas: a pilot study. J Cancer Res Clin Oncol 122, 676–678 (1996). https://doi.org/10.1007/BF01209031
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DOI: https://doi.org/10.1007/BF01209031