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Time course of nigrostriatal degeneration in parkinson's disease

A detailed study of influential factors in human brain amine analysis

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Journal of Neural Transmission Aims and scope Submit manuscript

Summary

It could be shown that the post mortem analysis of biogenic amines, precursors, and metabolites in the human brain are influenced by various parameters.

  1. 1.

    The patient's medical history; long term observation of the course of the disease; age; sex.

  2. 2.

    Terminal illness; duration of terminal illness.

  3. 3.

    Previous treatment with drugs; last drugs.

  4. 4.

    Time interval between last drug treatment and death; time of day and date of last drug consumption.

  5. 5.

    Rapidity of death; time of death; duration of coma.

  6. 6.

    Changes occurring in tissues before death; patient's constitution during terminal illness.

  7. 7.

    Changes in concentration of the biogenic amines, precursors, and metabolites depending on the patient's age.

  8. 8.

    Time between death and necropsy.

  9. 9.

    Dissection of specimen.

  10. 10.

    Period of storage; temperature of storage.

  11. 11.

    Chronobiological rhythm of substances.

  12. 12.

    Methods of assay.

  13. 13.

    Homogeneity of all mentioned parameters in the control group and patient group.

For the first time it could be demonstrated that the time course of nigrostriatal degeneration, independent of the age of the parkinsonian at the beginning of the illness, is linear for the last stage and the denervation progressively increases as the duration of illness progresses.

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Author notes

  1. P. Riederer

    Present address: Ludwig Boltzmann Neurochemistry Institute, Geriatric Hospital of the City of Vienna-Lainz, Austria

Authors and Affiliations

  1. Ludwig Boltzmann Neurochemistry Institute, Geriatric Hospital of the City of Vienna-Lainz, Austria

    St. Wuketich

  2. The Pathological Institute of the Hospital of the City of Vienna-Lainz, Austria

    P. Riederer & St. Wuketich

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  1. P. Riederer
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Dedicated to ProfessorW. Birkmayer, M.D., on the occasion of his 65th birthday.

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Riederer, P., Wuketich, S. Time course of nigrostriatal degeneration in parkinson's disease. J. Neural Transmission 38, 277–301 (1976). https://doi.org/10.1007/BF01249445

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  • DOI: https://doi.org/10.1007/BF01249445

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