Summary
In a prospective study of 85 patients with operation of colorectal cancer intraoperative ultrasonography of the liver was performed for the detection of liver metastases. The findings were compared with the results of preoperative ultrasonography and CT-scan as well as the findings of intraoperative inspection and palpation of the liver. Seventeen (24.3%) of a total of 70 metastases of this series could only be detected by intraoperative ultrasonography. This was related to 12 (14.1 %) of the examined patients. Four (5.7%) of these lesions were solitary and concerned 4.7% of the cases. Due to the intraoperative sonographic findings the tactics of operation was changed in 15.3% of the patients. Intraoperative ultrasonography has a significantly higher sensitivity for the detection of liver metastases from colorectal cancer than preoperative ultrasonography and computed tomography or intraoperative inspection and palpation. Intraoperative ultrasonography of the liver should be applied in all patients without preoperative evidence of liver metastases and in patients with a planned resection of metastases.
Zusammenfassung
In einer prospektiven Studie wurde bei 85 Patienten mit Operation colorectaler Carcinome eine intraoperative Sonographie der Leber zum Nachweis von Lebermetastasen durchgeführt. Die Befunde wurden verglichen mit den Ergebnissen der präoperativ vorgenommenen Sonographie und Computertomographie sowie der intraoperativen Inspektion und Palpation der Leber. Siebzehn (24,3%) der insgesamt 70 Metastasen dieser Untersuchungsserie konnten allein durch die intraoperative Sonographie nachgewiesen werden. Dieses betraf 12 (14,1%) der untersuchten Patienten. Vier (5,7%) dieser Herde waren solitär und betrafen 4,7% der Fälle. In 15,3% der Patienten wurde aufgrund der intraoperativen Ultraschallbefunde die Operationstaktik geändert. Beim Nachweis von Lebermetastasen colorectaler Carcinome hat die intraoperative Sonographie eine signifikant höhere Sensitivität als die präoperative Sonographie und Computertomographie bzw. die intraoperative Inspektion und Palpation. Die intraoperative Ultraschalluntersuchung sollte bei allen Patienten ohne präoperativen Nachweis von Lebermetastasen und bei Patienten mit geplanter Metastasenresektion durchgeführt werden.
Similar content being viewed by others
Literatur
Adson MA, van Heerden JA, Adson MH, Wagner JS, Ilstrup DM (1984) Resection of hepatic metastases from colorectal cancer. Arch Surg 119:647–651
Alderson PO, Adams BS, McNeal BJ (1983) Computertomography, ultrasound and scintigraphy of the liver in patients with colon carcinoma: prospective comparison. Radiology 149:225–230
Balch CM, Urist MM, Soong SJ, McGregor M (1983) A prospective phase 11 clinical trial of continous FUDR regional chemotherapy for colorectal metastases to the liver using a totally implantable drug infusion pump. Ann Surg 198:567–573
Bengmark S, Hafstrom L (1966) The natural history of primary and secondary malignant tumors of the liver: I. The prognosis for patients with hepatic metastases from colonic and rectal carcinoma at laparotomy. Cancer 23:198–202
Bengtsson G, Karlsson G, Havstrom L, Jonsson E (1981) Natural history of patients with untreated liver metastases from colorectal cancer. Am J Surg 141:586–589
Bismuth H, Castaing D, Gordon OJ (1987) The use of operative ultrasound in surgery of primary liver tumors. Word J Surg 11:610–614
Boldrini G, deGaetano AM, Giovanni I, Castagneto M, Colagrande C, Castiglioni G (1987) The systematic use of operative ultrasound for detection of liver metastases during colorectal surgery. World J Surg 11:622–627
Butler J, Attiyeh SS, Daly JM (1986) Hepatic resection for metastases of the colon and rectum. Surg Gynecol Obstet 162:109–113
Cady D, McDermott WV (1985) Major hepatic resection for metachronous metastases from colon cancer. Ann Surg 201:204–209
Castaing D, Emont J, Kunstlinger F, Bismuth H (1986) Utility of operative ultrasound in the surgical management of liver tumors. Ann Surg 204:600–605
Charnley RM, Morris DL, Dennison HR, Griffith CDN, Amar FS, Hardcastle JD (1988) Intraoperative ultrasound: more accurate staging of colorectal cancer. Surg Endosc 2:112
Coppa GS, Eng K, Ranson JHC, Gouge TH, Localio SA (1985) Hepatic resection for metastatic colon and rectal cancer. Ann Surg 202:203–208
Couinaud C (1957) Le foie etudes anatomiques et chirurgicales. Masson, Paris
Deixonne B, Lopez FM (1988) Operative ultrasonography during hepatobiliary and pancreatic surgery. Springer, Berlin Heidelberg New York
Finlay IG, Meek WR, Gray HW (1982) Incidence and detection of occult hepatic metastases in colorectal carcinoma. Br Med J 284:803–805
Finlay IG, McArdle CS (1986) Occult hepatic metastases of colorectal carcinoma. Br J Surg 73:732–735
Finlay IG, Meek D, Brunton F, McArdle CS (1988) Growth rate of hepatic metastases in colorectal carcinoma. Br J Surg 75:641–644
Gianola SJ, Dwyer A, Jones AE, Sugarbaker PH (1984) Prospective studies of laboratory and radiologic tests in the management of colon and rectal cancer. Dis Colon Rectum 27:806–818
Goligher JC (1941) The operability of carcinoma of the rectum. Br Med J II:393–397
Gozzetti G, Mazziotti A, Bolondi L, Cavalari A, Grisioni W, Casanova E, Beluschi R, Villanacci V, Labo G (1986) Intraoperative ultrasonography in surgery for liver tumors. Surgery 99:523–529
Greenway B (1988) Hepatic metastases from colorectal cancer: resection or not. Br J Surg 75:513–519
Iwazuki S, Shaw BW, Starzl TE (1983) Experience with 115 liver resections. Ann Surg 197:247–253
Kemeny MM, Hogan JN, Ganteaune L, Goldberg DA, Terz JJ (1986) Preoperative staging with computerized axial tomography and biochemical laboratory tests in patients with hepatic metastases. Ann Surg 203:169–172
Klotter HJ, Sattler J, Rothmund M (1988) Intraoperative sonography with surgical liver disease. Surg Endosc 2:142–143
Machi J, Isomoto H, Yamashita Y, Kurohiji T, Shirouzu K, Kakegawa T (1987) Intraoperative ultrasonography in screening for liver metastases from colorectal cancer. Comparative accuracy with traditional procedures. Surgery 101:678–684
Machi J, Isomoto H, Kurohiji T, Shirouzu K, Yamashida Y, Kakegawa T, Sigel B (1986) Detection of unrecognized liver metastases from colorectal cancer by routine use of ultrasonography. Dis Colon Rectum 29:405–409
Makuuchi M, Hasegawa H, Yamazaki S (1985) Ultrasonically guided subsegmentectomy. Surg Gynecol Obstet 161:246–250
Makuuchi M (1987) Abdominal intraoperative ultrasonography. Igaku-Shoin, Tokyo New York
Makuuchi M, Hasegawa H, Yamazaki S, Takayasu K, Moriyama N (1985) The use of operative ultrasound as an aid to liver resection in patients with hepatocellular carcinoma. World J Surg 11:615–621
Mooney B, Critchley M, Grime S, Taylor I (1981) Portal vein liver scanning for early detection of liver metastases in colorectal cancer. Gut 25a:436
Oxley EN, Ellis H (1969) Prognosis of carcinoma of the large bowel in the presence of liver metastases. Br J Surg 56:149–152
Riether RD, Khubghandani ET, Sheets JA, Stasik JJ, Rosen L (1985) A prospective study of continous hepatic perfusion with implantable pump. Dis Colon Rectum 28:24–26
Rich JA, Dailey JM (1985) Treatment of colorectal hepatic metastases. Surg Gynecol Obstet 161:597–607
Smith TJ, Kemeny NN, Sugarbaker PH (1982) A prospective study of hepatic imaging in the detection of metastatic disease. Ann Surg 195:486–491
Temple DF, Parthasarathy KL, Bakshi SP, Mittelman AE (1983) A comparison of isotopic and computerized tomographic scanning in the diagnosis of metastases of the liver in patients with adenocarcinoma of the colon and rectum. Surg Gynecol Obstet 156:205–208
Thomas WM, Morris DL, Hardcastle JD (1987) Contest ultrasonography in the detection of liver metastases from colorectal cancer: An in-vitro study. Br J Surg 74:955–956
Ward BA, Miller DL, Frank JA, Dwyer AJ, Simmons JTh, Chang R, Shawker ThH, Choyke P, Chang AE (1989) Prospective evaluation of hepatic imaging studies in detection of colorectal metastases: Correlation with surgical findings. Surgery 105:180–187
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hölscher, A.H., Stadler, J. Intraoperative Sonographie zum Nachweis occulter Lebermetastasen beim colorectalen Carcinom. Langenbecks Arch Chiv 374, 363–369 (1989). https://doi.org/10.1007/BF01262816
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01262816