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References
University Group Diabetes Program. A study of the effects of hypoglycaemic agents on vascular complications in patients with adult-onset diabetes. V. Evaluation of phenformin therapy. Diabetes24 (Suppl. 1), 65–184 (1975)
Jarrett, R.J., Keen, H., Fuller, J.H., McCartney, M.: Treatment of borderline diabetes: controlled trial using carbohydrate restriction and phenformin. Br. Med. J.1977 II, 861–865
Królewski, A.S., Czyzyk, A., Janeczko, D., Kopczýnski, J.: Mortality from cardiovascular diseases among diabetics. Diabetologia13, 345–350 (1977)
Cohen, R.D., Woods, H.F.: Clinical and biochemical aspects of lactic acidosis, p. 189. Oxford: Blackwell Scientific Publications 1976
Luft, D., Schmülling, R.M., Eggstein, M.: Lactic acidosis in biguanide-treated diabetics. A review of 330 cases. Diabetologia14, 75–87 (1978)
Kreisberg, R.A.: Glucose metabolism in normal and obese subjects. Effect of phenformin. Diabetes17, 481–488 (1968)
Searle, G.L., Schilling, S., Porte, D., Barbaccia, J., De Grazia, J., Cavalieri, R.R.: Body glucose kinetics in nondiabetic human subjects after phenethylbiguanide. Diabetes15, 173–178 (1966)
Craig, J.W., Miller, M., Woodward, H., Merik, E.: Influence of phenethylbiguanide on lactic, pyruvic and citric acids in diabetic patients. Diabetes9, 186–193 (1960)
Varma, S.K., Heaney, S.J., Whyte, W.G., Walker, R.S.: Hyperlactataemia in phenformin-treated diabetics. Br. Med. J.1972 I, 205–206
Nattrass, M., Todd, P.G., Hinks, L., Lloyd, B., Alberti, K.G.M.M.: Comparative effects of phenformin, metformin and glibenclamide on metabolic rhythms in maturity-onset diabetics. Diabetologia13, 145–152 (1977)
Nattrass, M., Lloyd, B., Todd, P.G.: Metabolic effects of combined sulphonylurea and biguanide therapy. Diabetologia12, 411 (1976)
Wildenhoff, K.E.: The influence of diabetic regulation on the diurnal variation in blood and the urinary excretion of ketone bodies. Acta. Med. Scand.198, 127–133 (1975)
Kattermann, R., Appels, A., Hubrich, K., Proschek, H., Söling, H.D., Creutzfeldt, W.: Untersuchungen über die Wirkung von Diät, Tolbutamid und Buformin sowie deren Kombination auf Körpergewicht und verschiedene Stoffwechselgrößen bei Diabetikern. II. Freie Fettsäuren, Ketonkörper, Triglyceride und Cholesterin im Blut. Diabetologia4, 221–228 (1968)
Mehnert, H.: Biguanid-induzierte Laktazidosen bei Diabetikern. Muench. Med. Wochenschr.119, 9–10 (1977)
Berger, W., Mehnert-Aner, S., Mülly, K., Heierli, Ch., Ritz, R.: 10 Fälle von Lactatazidose unter Biguanidtherapie (Buformin und Phenformin). Schweiz. Med. Wochenschr.106, 1830–1834 (1976)
Nattrass, M., Arthur, M.J., Smythe, P., McGill, J.I., Todd, P. G., Alberti, K. G.M.M.: Hyperlactataemia in diabetics with retinopathy during combined sulphonylurea and phenformin therapy. Diabète et Metabolisme (in press)
Schäfer, G.: Interactions of biguanides with mitochondrial and synthetic membranes. The role of phospholipids as natural binding sites. Eur. J. Biochem.45, 57–66 (1974)
Caspary, W.F., Creutzfeldt, W.: Analysis of inhibitory effect of biguanides on glucose absorption: inhibition of active sugar transport. Diabetologia7, 379–385 (1971)
Czyzyk, A., Tawecki, J., Sadowski, J., Ponikowska, I., Szezepanik, Z.: Effect of biguanides on intestinal absorption of glucose. Diabetes17, 492–198 (1968)
Caspary, W.F., Creutzfeldt, W.: Inhibition of intestinal amino acid transport by blood sugar lowering biguanides. Diabetologia9, 6–12 (1973)
Creutzfeldt, W., Willms, B., Caspary, W.: The mechanism of action of the blood glucose lowering biguanides. In: R.R. Rodriguez, J. Vallance-Owen (Eds.): Diabetes. Proceedings of the VIIth Congress of the International Diabetes Federation, Buenos Aires, 1970, pp. 708–719. Amsterdam: Excerpta Medica 1971
Tomkin, G.H.: Malabsorption of vitamin B12 in diabetic patients treated with phenformin: a comparison with metformin. Br. Med. J.1973 III, 673–675
Butterfield, W.J.H., Whichelow, M.J.: The hypoglycemic action of phenformin. Effect of phenformin on glucose metabolism in peripheral tissues. Diabetes11, 281–286 (1962)
Meyer, F., Ipaktchi, M., Clauser, H.: Specific inhibition of gluconeogenesis by biguanides. Nature213, 203–204 (1967)
Cook, D.E., Blair, J.B., Lardy, H.A.: Mode of action of hypoglycaemic agents. V. Studies with phenethylbiguanide in isolated perfused rat liver. J. Biol. Chem.248, 5272–5277 (1973)
Haeckel, R., Haeckel, H.: Inhibition of gluconeogenesis from lactate by phenylethylbiguanide in the perfused guinea pig liver. Diabetologia8, 117–124 (1972)
Schäfer, G.: Some new aspects on the interaction of hypoglycemia-producing biguanides with biological membranes. Biochem. Pharmacol.25, 2015–2024 (1976)
Beckmann, R.: Über die Resorption und den biologischen Abbau von 1-(ß-Phenäthyl)-biguanid (Phenformin). Diabetologia3, 368–376 (1966)
Beckmann, R.: Resorption, Verteilung im Organismus und Ausscheidung von Metformin. Diabetologia5, 318–324 (1969)
Czyzyk, A., Lao, B., Bartosiewicz, W., Szczepanik, Z., Orlowska, K.: The effect of short-term administration of antidiabetic biguanide derivatives on the blood lactate levels in healthy subjects. Diabetologia14, 89–94 (1978)
Waters, A.K., Morgan, D.B., Wales, J.K.: Blood lactate and pyruvate levels in diabetic patients treated with biguanides with and without sulphonylureas. Diabetologia14, 95–98 (1978)
Assan, R., Heuclin, Ch., Ganeval, D., Bismuth, Ch., George, J., Girard, J.R.: Metformin-induced lactic acidosis in the presence of acute renal failure. Diabetologia13, 211–217 (1977)
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Nattrass, M., Alberti, K.G.M.M. Biguanides. Diabetologia 14, 71–74 (1978). https://doi.org/10.1007/BF01263443
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DOI: https://doi.org/10.1007/BF01263443