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Involvement of glycoprotein C (gC) in adsorption of herpes simplex virus type 1 (HSV-1) to the cell

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Summary

Results demonstrating involvement of glycoprotein C (gC) of herpes simplex type 1 virus (HSV-1) in attachment of the virus to the cell are presented. Monoclonal antibodies against gC-1 inhibited adsorption of gC+-strains. The gC−-mutant, MP, attached to cells but at a reduced rate. Attachment of the MP-mutant was unaffected by presence of anti-gC-1 antibody. Purified truncated gC-1 adsorbed to cells at a rate essentially the same as that of gC+-virus. Glycoprotein C-1 pretreated with heparin did not adsorb to cells. The results are compatible with a suggested role for gC in HSV attachment.

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Authors and Affiliations

  1. Department of Clinical Virology, University of Göteborg, Göteborg, Sweden

    B. Svennerholm, S. Jeansson, A. Vahlne & E. Lycke

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  1. B. Svennerholm
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  2. S. Jeansson
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  3. A. Vahlne
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  4. E. Lycke
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Svennerholm, B., Jeansson, S., Vahlne, A. et al. Involvement of glycoprotein C (gC) in adsorption of herpes simplex virus type 1 (HSV-1) to the cell. Archives of Virology 120, 273–279 (1991). https://doi.org/10.1007/BF01310482

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  • DOI: https://doi.org/10.1007/BF01310482

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