Skip to main content
SpringerLink
Log in

DNA restriction analysis of adenovirus prototypes 1 to 41

  • Original Papers
  • Published:
Archives of Virology Aims and scope Submit manuscript

Summary

DNA restriction patterns of all known human adenovirus prototypes (1 to 41), ordered according to subgenera A to F, are presented for restriction endonucleases BamHI, BgIII, BstEII, HindIII, and SmaI. This catalogue is a prerequisite for typing of adenoviruses by DNA restriction analysis in diagnostic laboratories and for strain identification in reference laboratories. To determine the genetic relationship of human adenoviruses within a subgenus and between subgenera, a pairwise analysis of comigrating fragments was performed. Adenoviruses of subgenus C were closely related. Adenoviruses of subgenus B showed two related clusters of four types each, whereas the numerous serotypes of subgenus D did not show any corresponding clustering. Little comigration was observed between DNA restriction fragments from members of subgenus A or F respectively.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Adrian Th, Bastian B, Benoist W, Hierholzer JC, Wigand R (1985) Characterization of adenovirus 15/H9 intermediate strains. Intervirology 23: 15–22

    Google Scholar 

  2. Adrian Th, Heinrich W (1986) COMAP: a comigrating analysis program for estimating the relationship of adenoviruses on the genome level. Nucleic Acid Res 14: 559–565

    Google Scholar 

  3. Adrian Th, Wigand R, Hierholzer JC (1985) Immunological and biochemical characterization of adenovirus strains from subgenus B. II. DNA analysis. Arch Virol 84: 78–89

    Google Scholar 

  4. De Jong JC, Wigand R, Adrian Th, Hierholzer JC, Kapsenberg JG, Muzerie CJ, Wermenbol AG (1984) Adenovirus 38: a new human adenovirus species of subgenus D. Intervirology 22: 164–169

    Google Scholar 

  5. De Jong JC, Wigand R, Kidd AH, Wadell G, Kapsenberg JG, Muzerie CJ, Wermenbol AG, Firtzlaff R-G (1983) Candidate adenoviruses 40 and 41: fastidious adenoviruses from human infant stool. J Med Virol 11: 215–231

    Google Scholar 

  6. De Jong PJ, Valderrama G, Spigland I, Horwitz MS (1983) Adenovirus isolates from urine of patients with acquired immunodeficiency syndrome. Lancet i: 1293–1296

    Google Scholar 

  7. Doerfler W (1969) Nonproductive infection of baby hamster kidney cells (BHK 21) with adenovirus type 12. Virology 38: 587–606

    Google Scholar 

  8. Duggleby RG, Kinns H, Rood JI (1981) A computer program for determining the size of DNA restriction fragments. Analyt Biochem 110: 49–55

    Google Scholar 

  9. EMBL Nucleotide Sequence Data Library, European Molecular Biology Laboratory (1984) P.O. Box 10 22 09, D-6900 Heidelberg, Federal Republic of Germany

  10. Fife KH, Ashley R, Corey L (1985) Isolation and characterization of six new genome types of human adenovirus types 1 and 2. J Clin Microbiol 21: 20–23

    Google Scholar 

  11. Fife KH, Ashley R, Shields AF, Curfman MF, Salter D, Meyers JD, Corey L (1985) Comparison of neutralization and DNA restriction enzyme methods for typing clinical isolates of human adenovirus. J Clin Microbiol 22: 95–100

    Google Scholar 

  12. Garon CF, Berry KW, Hierholzer JC, Rose JA (1973) Mapping of base sequence heterologies between genomes from different adenovirus serotypes. Virology 54: 414–426

    Google Scholar 

  13. Gingeras TR, Sciaky D, Gelinas RE, Bing-Dong J, Yen CE, Kelly MM, Bullock PA, Parsons BL, O'Neill KE, Roberts RJ (1982) Nucleotide sequences from the adenovirus-2 genome. J Biol Chem 257: 13,475–13,491

    Google Scholar 

  14. Green M, Mackey JK, Wold WSM, Rigden P (1979) Thirty-one human adenovirus serotypes (Ad 1-Ad 31) form five groups (A-E) based upon DNA genome homologies. Virology 93: 481–492

    Google Scholar 

  15. Hammarskjöld M-L, Winberg G (1980) Encapsidation of adenovirus 16 DNA is directed by a small DNA sequence at the left end of the genome. Cell 20: 787–795

    Google Scholar 

  16. Hammond GW, Mauthe G, Joshua J, Hannan CK (1985) Examination of uncommon clinical isolates of human adenoviruses by restriction endonuclease analysis. J Clin Microbiol 21: 611–616

    Google Scholar 

  17. Hierholzer JC, Anderson L, Bingham P, Stone Y, Gold J (1984) Adenoviruses from patients with acquired immune deficiency syndrome. Abstracts 6th international congress of virology, Sendai, Japan, September 1984, p 17

  18. Hierholzer JC, Kemp MC, Gary Jr GW, Spencer HC (1982) New human adenovirus associated with respiratory illness: candidate adenovirus type 39. J Clin Microbiol 16: 15–21

    Google Scholar 

  19. Horwitz MS, Valderrama G, Korn R, Spigland I (1984) Adenovirus isolates from the urines of AIDS patients: characterization of group B recombinants. Proc. UCLA symposium on AIDS. Alan R Liss, New York, pp 187–207

    Google Scholar 

  20. Kemp MC, Hierholzer JC (1986) Three adenovirus 8 genome types defined by restriction enzyme analysis: prototype stability in geographically separated populations. J Clin Microbiol 23: 469–474

    Google Scholar 

  21. Kemp MC, Hierholzer JC, Cabradilla CP, Obijeski JF (1983) The changing etiology of epidemic keratoconjunctivitis: antigenic and restriction enzyme analyses of adenovirus types 19 and 37 isolated over a ten year period. J Infect Dis 148: 24–33

    Google Scholar 

  22. Kidd AH (1984) Genome variants of adenovirus 41 (subgroup G) from children with diarrhoea in South Africa. J Med Virol 14: 49–59

    Google Scholar 

  23. Robinson CC, Tibbetts C (1984) Polar encapsidation of adenovirus DNA: evolutionary variants reveal dispensable sequences near the left ends of Ad3 genomes. Virology 137: 276–286

    Google Scholar 

  24. Takiff HE, Reinhold W, Garon CF, Straus SE (1984) Cloning and physical mapping of enteric adenoviruses (candidate types 40 and 41) J Virol 51: 131–136

    Google Scholar 

  25. Uhnoo I, Wadell G, Svensson L, Johansson M (1983) Two new serotypes of enteric adenoviruses causing diarrhea. Dev Biol Stand 53: 311–318

    Google Scholar 

  26. Van Loon AE, Rozijn ThH, De Jong JC, Sussenbach JS (1985) Physicochemical properties of the DNAs of the fastidious adenovirus species 40 and 41. Virology 140: 197–200

    Google Scholar 

  27. Wadell G (1984) Molecular epidemiology of adenoviruses. Curr Top Microbiol 110: 191–220

    Google Scholar 

  28. Wadell G, Hammarskjöld M-L, Winberg G, Varsanyi TM, Sundell G (1980) Genetic variability of adenoviruses. Ann NY Acad Sci 354: 16–42

    Google Scholar 

  29. Wadell G, Sundell G, De Jong JC (1981) Characterization of candidate adenovirus 37 by SDS-polyacrylamid gel electrophoresis of virion polypeptides and DNA restriction site mapping. J Med Virol 7: 119–125

    Google Scholar 

  30. Wadell G, Varsanyi TM (1978) Demonstration of three different subtypes of adenovirus type 7 by DNA restriction site mapping. Infect Immun 21: 238–246

    Google Scholar 

  31. Wadell G, Varsanyi T, Lord A, Sutton RNP (1980) Epidemic outbreaks of adenovirus 7 with special reference to the pathogenicity of adenovirus genome type 7 b. Am J Epidem 112: 619–628

    Google Scholar 

  32. Wigand R, Adrian Th (1986) Classification and epidemiology of adenoviruses. In:Doerfler W (ed) Adenovirus DNA: the viral genome and its expression. Martinus Nijhoff Publ, Boston, pp 409–441

    Google Scholar 

  33. Wigand R, Bartha A, Dreizin RS, Esche H, Ginsberg HS, Green M, Hierholzer JC, Kalter SS, McFerran JB, Pettersson U, Russell WC, Wadell G (1982) Adenoviridae: Second report. Intervirology 18: 169–176

    Google Scholar 

  34. Wigand R, Gelderblom H, Özel M, Distler H, Adrian Th (1983) Characteristics of mastadenovirus h 8, the causative agent of epidemic keratoconjunctivitis. Arch Virol 76: 307–319

    Google Scholar 

  35. Wigand R, Gelderblom H, Wadell G (1980) New human adenovirus (candidate adenovirus 36), a novel member of subgroup D. Arch Virol 64: 225–233

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Abteilung für Virologie, Institut für Medizinische Mikrobiologie und Hygiene, Universitätskliniken, Homburg (Saar), Germany

    Th. Adrian & R. Wigand

  2. Department of Virology, University of Umea, Sweden

    G. Wadell

  3. Center for Disease Control, Division of Viral Diseases, Atlanta, Georgia, USA

    J. C. Hierholzer

Authors
  1. Th. Adrian
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Wadell
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. C. Hierholzer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Wigand
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

With 10 Figures

Aided by grants from the “Deutsche Forschungsgemeinschaft” (Wi 3/21-1), the “Bundesministerium für Jugend, Familie und Gesundheit” FRG, and from the “Fördererverein der Deutschen Vereinigung zur Bekämpfung der Viruskrankheiten”.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Adrian, T., Wadell, G., Hierholzer, J.C. et al. DNA restriction analysis of adenovirus prototypes 1 to 41. Archives of Virology 91, 277–290 (1986). https://doi.org/10.1007/BF01314287

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01314287

Keywords

Search

Navigation