Summary
A patient is presented with primary adult-onset hypogammaglobulinemia and nodular lymphoid hyperplasia of the small intestine complicated by a jejunal lymphoma. The tumor was resected and was classified as a malignant diffuse histiocytic lymphoma with involvement of mesenteric lymph nodes. Gastroenterological, immunological, histological, and immunopathological studies on this case are reported. The possibility that nodular lymphoid hyperplasia of the small intestine in hypogammaglobulinemia is a premalignant condition is discussed.
Similar content being viewed by others
References
Naqvi MS, Burrows L, Kark AE: Lymphoma of the gastrointestinal tract. Ann Surg 170:221–231, 1969
Harris OD, Cooke WT, Thompson H, Waterhouse JAH: Malignancy in adult coeliac disease and idiopathic steatorrhoea. Am J Med 42:899–912, 1967
Brunt PW, Sircus W, MacLean N: Neoplasia and the coeliac syndrome in adults. Lancet 1:180–184, 1969
Stokel PL, Holmes GKT: MalignancyIn Coeliac Disease. WT Cooke, P Asquith (eds). London, WB Saunders, 1974, pp 159–170
Isaacson P, Wright DH: Intestinal lymphoma associated with malabsorption. Lancet 1:67–70, 1978
Seligmann M, Mihaesco E, Hurez D, Mihaesco C, Preud'-Homme J-L, Rambaud J-C: Immunochemical studies in fourcases of alpha chain disease. J Clin Invest 48:2374–2389, 1969
Hermans PE, Diaz-Buxo JA, Stobo JD: Idiopathic late-onset immunoglobulin deficiency. Am J Med 61:221–237, 1976
van Tongeren JHM, Majoor CLH: Demonstration of protein-losing gastroenteropathy. The disappearance rate of51Cr from plasma and the binding of51Cr to different serum proteins. Clin Chim Acta 14:31–41, 1966
Du Bois MJG, Huismans L, Schellekens ThA, Eijsvoogel VP: Investigation and standardization of the conditions for micro-lymphocyte cultures. Tissue Antigens 3:402–409, 1973
Leguit P Jr, Meinesz A, Huismans L, Eijsvoogel VP: The use of an antigen cocktail in the lymphocyte transformation test. Clin Exp Immunol 14:149–152, 1973
Rappaport H: Tumors of the hematopoietic system. Atlas of Tumor Pathology, Sect 3, Fasc 8, Washington DC, Armed Forces Institute of Pathology, 1966
Lukes RJ, Collins RD: Immunologic characterization of human malignant lymphomas. Cancer 34:1488–1503, 1974
Aisenberg AC, Long JC: Lymphocyte surface characteristics in malignant lymphomas. Am J Med 58:300–306, 1975
Bøyum A: Lymphocytes, isolation, fractionation and characterization. Scand J Immunol 5 (suppl 5):9–16, 1976
Jondal M, Holm G, Wigzell H: Surface markers on human T and B-lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. J Exp Med 136:207–215, 1972
Frank MM, Jaffe ES, Green I: Detection pf specific mononuclear cell receptors in tissue sections.In In Vitro Methods in Cell-Mediated and Tumor Immunity. BR Bloom, JR David (eds). New York, Academic Press, 1976, pp. 203–210.
Hermans PE, Huizenga KA, Hoffman HN, Brown AL Jr, Markowitz H: Dysgammaglobulinemia associated with nodular lymphoid hyperaplasia of the small intestine. Am J Med 40:78–89, 1966
Hughes WS, Brooks FP, Conn HO: Serum gastrin levels in primary hypogammaglobulinemia and pernicious anemia. Ann Intern Med 77:746–750, 1972
Twomey JJ, Jordan PH, Jarrold T, Trubowitz S, Ritz ND, Conn HO: The syndrome of immunoglobulin deficiency and pernicious anemia. Am J Med 47:340–350, 1969
Ament ME, Rubin CE: Relation of giardiasis to abnormal intestinal structure and function in gastrointestinal immunodeficiency syndromes. Gastroenterology 62:216–226, 1972
Kahn LB, Novis BH: Nodular lymphoid hyperplasia of the small bowel associated with primary small bowel reticulum cell lymphoma. Cancer 33:837–844, 1974
Kersey JH, Spector BD, Good RA: Primary immunodeficiency diseases and cancer: the immunodeficiency-cancer registry. Int J Cancer 12:333–347, 1973
Ajdukiewicz AB, Youngs GR, Bouchier IAD: Nodular lymphoid hyperaplasia with hypogammaglobulinaemia. Gut 13:589–595, 1972
Thomas L:In Cellular and Humoral Aspects of the Hypersensitivity States. HS Lawrence (ed). New York, H Hoeber, 1959, pp. 529–532.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lamers, C.B.H.W., Theo Wagener, D.J., Assmann, K.J.M. et al. Jejunal lymphoma in a patient with primary adult-onset hypogammaglobulinemia and nodular lymphoid hyperplasia of the small intestine. Digest Dis Sci 25, 553–557 (1980). https://doi.org/10.1007/BF01315216
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01315216