Summary
Subtype-1 isolates of Equine herpesvirus-1 (EHV-1) from a quadriplegic horse and from an aborted foetus were compared with each other and with a subtype-2 respiratory isolate. All 3 isolates were detected in the epithelium and macrophages of the respiratory tract. Both the paresis and foetal subtype-1 isolates replicated in the epithelium of the ileum and this correlated with the recovery of virus from faecesin vivo. The paresis subtype-1 isolate also had a predelection for vascular endothelial cells, particularly in the nasal mucosa, but also in the lungs, central nervous system, adrenal and thyroid.
In the 9 foals inoculated with the paresis isolate two developed hind limb dysfunction, four developed diarrhoea, and one of these 4 died with an intussusception.
The differences between these isolates are discussed in relation to other herpesviruses.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Bagust, T. J.: The equine herpesvirus. Vet. Bull., Weybridge41, 79–92 (1971).
Burrows, R., Goodridge, D.:In vivo andin vitro studies of equine rhinopneumonitis virus strains. Proc. 3rd Inf. Conf. Equine Infect. Dis., 306–321 (1972).
Doll, E. R., Bryans, J. T.: Epizootiology of equine viral rhinopneumonitis. J. Amer. vet. med. Ass.142, 31–37 (1963).
Dougherty, R. M.: Animal virus titration techniques. Experimental Virology, 169–233. New York: Academic Press 1974.
Edington, N., Plowright, W., Watt, R. G.: Generalised porcine cytomegalic inclusion disease: distribution of cytomegalic cells and virus. J. comp. Path.86, 191–202 (1976).
Edington, N., Patel, J. R., Mumford, J. A., Bridges, C. G.: Vascular changes in horses infected with a paresis inducing isolate of equine/herpesvirus-1 (in press).
Greenwood, R. E. S.: Rhinopneumonitis outbreak at Newmarket. Vet. Rec.104, 534–535 (1979).
Hanshaw, J. B.: Congenital and acquired cytomegalovirus infection. Virology Monographs, Vol. 3. Wien-New York: Springer 1968.
Kaplan, A. S.: Herpes simplex and pseudorabies virus. Virology Monographs, Vol. 5. Wien-New York: Springer 1969.
Manninger, R.: Studies on infectious abortions in mares due to a filterable virus. Acta vet. Acad. Sci., Hung.1, 62–68 (1949).
Mumford, J. A., Edington, N.: EHV-1 and equine paresis. Vet. Rec.106, 277 (1980).
Murthy, K. K., Calneck, B. W.: Marek's disease tumours associated antigen (MATSA) in resistant versus susceptible chickens. Avian Dis.23, 831–837 (1979).
Patel, J. R., Edington, N.: Differentiation of respiratory abortion and paresis isolates of equine herpes virus-1 (EHV-1) in mice. (In press.)
Purchase, H. G., Biggs, P. M.: Characterisation of five isolates of Marek's disease. Res. Vet. Sci.8, 440–446 (1967).
Sabine, M., Robertson, G. R., Whalley, J. M.: Differentiation of subtypes of equine herpesvirus-1 by restriction endonuclease analysis. Aust. vet. J.51, 148–149 (1981).
Saxegaard, F.: Isolation and identification of equine rhinopneumonitis virus (equine abortion virus) from cases of abortion and paralysis. Nord. vet. Med.18, 504–510 (1966).
Sharma, J. M., Burmester, B. R.: Immune mechanisms in Marek's Disease Comp. Immunol. Microbiol. infect. Dis.1, 153–159 (1979).
Thomson, G. R., Mumford, J. A., Campbell, J., Griffiths, L.: Serological detection of equine herpesvirus-1 infections of the respiratory tract. Equine vet. J.8, 58–65 (1976).
Turtinen, L. W., Allen, G. P., Darlington, R. W., Bryans, J. T.: Serologic and molecular comparisons of several equine herpesvirus type-1 strains. Am. J. vet. Res.42, 2099–2104 (1982).
York, C. J.: Infectious bovine rhinotracheitis. J. am. vet. med. Ass.152, 758–768 (1968).
Author information
Authors and Affiliations
Additional information
With 5 Figures
Rights and permissions
About this article
Cite this article
Patel, J.R., Edington, N. & Mumford, J.A. Variation in cellular tropism between isolates of Equine herpesvirus-1 in Foals. Archives of Virology 74, 41–51 (1982). https://doi.org/10.1007/BF01320781
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01320781