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Effect of steroids on iopamidol blood-brain transfer constant and plasma volume in brain tumors measured with X-ray computed tomography

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Summary

Tumor blood-brain transfer constant of iopamidol (K) and plasma volume (Vp) were measured in 10 patients with primary brain tumors before and after 7 days of dexamethasone treatment (4 × 4 mg per oral per day) using X-ray computed tomography. Both K and Vp decreased significantly after dexamethasone treatment with p < 0.01 and 0.09 respectively according to one-tail paired t-test. The mean percentage decrease in K and Vp was 32% and 10% respectively. Functional images of the two parameters before and after treatment were generated and showed clearly the effect of steroids on the reduction of K in brain tumors. In contrast, when before and after treatment contrast enhanced CT scans were compared, no difference was observed in the enhancement in 8 out of 10 cases. The result obtained support the conclusion that: (1) corticosteroids reduce the blood-brain permeability to small hydrophillic molecules; (2) the X-ray computed tomography method we have developed can be used to measure the K and Vp response of brain tumors to steroid therapy; and, (3) ordinary contrast enhanced CT scans at one fixed time or multiple times after contrast injection are not sensitive in detecting the reduction of K due to steroids.

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Authors and Affiliations

  1. Department of Diagnostic Radiology and Lawson Research Institute, St. Joseph's Health Centre and University of Western Ontario, N6A 4V2, London, Ontario, Canada

    W. T. Ivan Yeung, Ting -Yim Lee, Roman Kozak, John Bennett & Thomas Brown

  2. Department of Medical Biophysics, University of Western Ontario, N6A 3K7, London, Ont., Canada

    W. T. Ivan Yeung & Ting -Yim Lee

  3. Lawson Family Imaging Research Laboratories, The John P. Robarts Research Institute, N6A 5K8, London, Ont, Canada

    W. T. Ivan Yeung & Ting -Yim Lee

  4. Brain Research Laboratory, Clinical Research Unit, Department of Clinical Neurological Sciences, University of Western Ontario, N6A 4G5, London, Ont, Canada

    Rolando F. Del Maestro

Authors
  1. W. T. Ivan Yeung
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  2. Ting -Yim Lee
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  3. Rolando F. Del Maestro
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  4. Roman Kozak
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  5. John Bennett
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  6. Thomas Brown
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Yeung, W.T.I., Lee, T.Y., Del Maestro, R.F. et al. Effect of steroids on iopamidol blood-brain transfer constant and plasma volume in brain tumors measured with X-ray computed tomography. J Neuro-Oncol 18, 53–60 (1994). https://doi.org/10.1007/BF01324604

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