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Radiographic skeletal survey and radionuclide bone scan in Langerhans cell histiocytosis of bone

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Abstract

Background. The lack of a consensus in the literature on the imaging strategy in Langerhans cell histiocytosis (LCH) bone lesions in childhood.Objective. To evaluate the relative value of radionuclide bone scan (RBS) and radiographic skeletal survey (RSS) in the detection of LCH bone lesions, both in the initial work-up of the disease and during the follow-up period.Materials and methods. Ten children with bone lesions evaluated by means of RSS and RBS in a retrospective study (1984–1993).Results. Fifty radiologically and/or scintigraphically abnormal foci were detected: 27 anomalies in the initial work-up (12 by both RSS and RBS, 8 by RSS only and 7 by RBS only) and 23 additional anomalies during follow-up (10 by both RSS and RBS, 10 by RSS only and 3 by RBS only). RSS+/RBS- lesions (n =18) are more frequently encountered in the skull (P = 0.038), and more frequently lack radiologic signs of osteoblastic activity (P = 0.020), than RSS+/RBS+ lesions (n = 22). RSS-/RBS+ abnormalities (n = 10) were most frequently insignificant.Conclusion. In the initial work-up both RSS and RBS should be carried out, while in the follow-up only RSS should be performed.

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Authors and Affiliations

  1. Department of Radiology and Medical Imaging, Cliniques Universitaires St-Luc, University of Louvain Medical School, Avenue Hippocrate 10, B-1200, Brussels, Belgium

    Jean-Paul Van Nieuwenhuyse, Philippe Clapuyt, Jacques Malghem & Philippe Everarts

  2. Department of Nuclear Medicine, Cliniques Universitaires St-Luc, University of Louvain Medical School, Brussels, Belgium

    Jacques Melin & Stanislas Pauwels

  3. Department of Pediatric Hematology, Cliniques Universitaires St-Luc, University of Louvain Medical School, Brussels, Belgium

    Bénédicte Brichard, Jacques Ninane, Christiane Vermylen & Guy Cornu

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  1. Jean-Paul Van Nieuwenhuyse
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  2. Philippe Clapuyt
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  3. Jacques Malghem
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  4. Philippe Everarts
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  5. Jacques Melin
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  6. Stanislas Pauwels
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  7. Bénédicte Brichard
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  8. Jacques Ninane
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  9. Christiane Vermylen
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  10. Guy Cornu
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Van Nieuwenhuyse, JP., Clapuyt, P., Malghem, J. et al. Radiographic skeletal survey and radionuclide bone scan in Langerhans cell histiocytosis of bone. Pediatr Radiol 26, 734–738 (1996). https://doi.org/10.1007/BF01383393

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  • DOI: https://doi.org/10.1007/BF01383393

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