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A randomized trial comparing cimetidine to nasogastric suction in acute pancreatitis

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Abstract

Clinical and experimental evidence has suggested that the use of cimetidine might be harmful to patients with acute pancreatitis. We conducted a randomized study comparing cimetidine to nasogastric (NG) suction in 95 patients with 103 episodes of mild to moderately severe, acute or relapsing pancreatitis (86.4% alcohol related). The groups were comparable on entry to the study, and daily evaluation of several clinical and laboratory criteria revealed no consistent differences between the two groups. When these same criteria were evaluated for time of return to normal, if abnormal on entry to the study, no differences were found. The cimetidine group had a significantly shorter stay in the hospital than did the NG group (6.8±2.7 vs 8.5±4.8 days). Neither the incidence of relapse or complication nor the duration and extent of hyperamylasemia were significantly different between patients treated with cimetidine or NG suction. We conclude that cimetidine is safe to use in patients with mild to moderately severe alcohol-related pancreatitis, but it offers minimal advantage over NG suction.

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References

  1. Field BW, Hepner GW, Shabot MM, Schwartz AA, State D, Worthen N, Wilson R: Nasogastric suction in alcohol pancreatitis. Dig Dis Sci 24:339–344, 1979

    PubMed  Google Scholar 

  2. Levant JA, Secrist DM, Resin H, Sturdevant RAL, Guth PH: Nasogastric suction in the treatment of alcoholic pancreatitis. A controlled study. J Am Med Assoc 229:51–52, 1974

    Google Scholar 

  3. Naeije R, Salingret E, Clumeck N, Troyer ADe, Devis G: Is nasogastric suction necessary in acute pancreatitis? Br Med J 2:659–660, 1978

    PubMed  Google Scholar 

  4. Joffee SN, Lee FD: Acute pancreatitis after cimetidine administration in experimental duodenal ulcer. Lancet 1:383, 1978 (letter)

    Google Scholar 

  5. Hadas N, Wapnick S, Grosberg SJ: Cimetidine in pancreatitis. N Engl J Med 299:487, 1978 (letter)

    Google Scholar 

  6. Meshkinpour H, Molinari MD, Gardner L, Berk JE, Hoehler, FK: Cimetidine in the treatment of acute alcoholic pancreatitis. A randomized, double-blind study. Gastroenterology 77:687–690, 1979

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine, Division of Gastroenterology and General Internal Medicine, University of Colorado School of Medicine, 4200 E. 9th Avenue, 80262, Denver, Colorado

    John S. Goff MD, Lawrence E. Feinberg MD & William R. Brugge MD

Authors
  1. John S. Goff MD
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  2. Lawrence E. Feinberg MD
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  3. William R. Brugge MD
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Supported by a grant from Smith, Kline and French Laboratories, Philadelphia, Pennsylvania.

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Goff, J.S., Feinberg, L.E. & Brugge, W.R. A randomized trial comparing cimetidine to nasogastric suction in acute pancreatitis. Digest Dis Sci 27, 1085–1088 (1982). https://doi.org/10.1007/BF01391445

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  • DOI: https://doi.org/10.1007/BF01391445

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