Summary
36 consecutive years' experience in treating 104 cases of posterior fossa haemangioblastomas is described and discussed. The mortality was 24%, with a tendency to decrease, reaching 20% in the last 15 years. About half the patients returned to neurological normality and full working capacity. Dividing the lesions into solid and cystic tumours, cystic tumours were more frequent, their survival was longer, recurrence less and postoperative state somewhat better.
Similar content being viewed by others
References
Adair LB (1978) Cerebellarhaemangioblastoma: computed tomographic, angiographic and clinical correlations in seven cases. Comput Tomogr 4: 281–294
Babchin IL (1962) On the familial angioreticulomata of the cerebellum. Voprosy Neurochirurgii 26: 54–59
Berblinger W (1992) Zur Auffassung von der sogenannten v. Hippeischen Krankheit der Netzhaut (Capillares Haemangiom im verlängerten Mark) A von Graefes Arch Ophtalmol 110: 395–414
Brandt R (1921) Zur Frage der Angiomatosis retinae. A von Graefes Arch Ophtalmol 106: 127–165
Broager B (1949) Multiple cerebellar angioreticulomas. Discussion of high protein contents of the cysts and of enclosed parts of the subarachnoid space. Acta Psychiatr Neurol Scand 24: 317–332
Brody JF, Rodriguez F (1961) Cerebellar hemangioblastoma and polycythemia (erythrocytemia) Am J Med Sci 272: 579–584
Carpenter G, Schwartz HG, Walker AE (1943) Neurogenic polycythemia. Ann Intern Med 19: 470–481
Cramer F, Kimsey WH (1952) The cerebellar haemangioblastoma; review of 53 cases, with special reference to cerebellar cysts and association of polycythemia. Arch Neurol Psychiatry 67: 237–252
Constans JP, Meder F, Maiuri F, Donzelli R, Spaziente R, de Divitiis E (1986) Posterior fossa hemangioblastomas. Surg Neurol 25: 269–275
Gushing H, Bailey P (1932) Tumors arising from the blood-vessels of the brain: angiomatous malformations and hemangioblastomas. Thomas, Springfield, Ill
Di Chiro G (1957) Combined retino-cerebellar angiomatosis and deep cervical angiomas: case report. J Neurosurg 14: 685–687
Djindjian R, Hurth M, Houdart R (1971) Haemangioblastomes medullaires et maladie de I. Hippel Lindau Rev Neurol 124: 495
Ganti SR, Silver AH, Hilal SH (1982) Computed tomography of cerebellar hemangioblastomas. J Comput Assist Tomogr 6: 912–919
Garcia-Bengochea F, Berk M (1965) The so-called solid hemangioblastoma of the cerebellum and vertebral angiography. J Neurosurg 22: 35–39
Guerin J, Biulac B, Caillé JM, Pouyanne H (1974) Les hemangioblastomes multiples. Neurochirurgie 20: 565–582
Handa J, Miwa Y, Shimizu Y, Handa H (1974) Cerebellar haemangioblastoma with an enlarged tentorial artery. Surg Neurol 2: 55–57
Hennessy TG, Stern WE, Herrick SE (1967) Cerebellar hemangioblastoma: erythropoetic activity by radioiron assay. J Nucl Med 8: 601–608
Hippel E (1904) Über eine sehr seltene Erkrankung der Netzhaut. Klinische Beobachtungen. Arch J Ophtal 59: 83–106
Iswar S, Tanigochi RM, Vogel FS (1971) Multiple supratentorial haemangioblastomas. J Neurosurg 35: 394–405
Jamieson KG, Yelland JDN, Merry GS (1974) Haemangioblastomas of the hindbrain: a report of 18 cases. Aust NZJ Surg 44: 254–257
Jeffreys R (1975) Clinical and surgical aspects of posterior fossa hemangioblastoma. J Neurol Neurosurg Psychiatry 38: 105–111
Hoff JT, Ray BS (1968) Cerebral hemangioblastoma occurring in a patient with von Hippel-Lindau disease. J Neurosurg 28: 365–368
Julien PP (1962) Hemangioblastome du cervelet accompagne d'une polycythemie. Un Med Canad 91: 749–752
Julow J, Pásztor E (1975) Cerebellaris haemangioblastoma Id-eggyógy. Szemle 28: 371–376
Kawano T, Iwamoto K, Mori K, Matsuse E (1985) Multicentric hemangioblastomas in the cerebellum. Surg Neurol 24: 677–680
Kawafuchi J, Shirakura T, Azuma M, Tsunoda T, Maekawa T (1970) Hematological study on a case with cerebellar hemangioblastoma associated with erythrocytosis, with special reference to a erythropoiesis-with special reference to a erythropoiesis-stimulating activity present in the fluid of the cyst of tumour. Blut 20: 69–75
Krayenbühl HA, Yasargil MG (1958) Das Kleinhirnhemangiom. Schweiz Med Wochenschr 88: 99–104
Lagré J, Sedan R, Lavielle J, Clement JP, Paillas JE (1968) Maladie de von Hippel-Lindau. Ablation des angioreticulomes cerebelleux et guerison. Etude neuroradiologique avec exploration angiographique selective des localisations viscerales. Neurochirurgie 14: 538–597
Leu HJ, Ruttner JR (1973) Angioretikulome des Zentralnervensystems. Acta Neurochir (Wien) 29: 73–82
Lindau A (1926) Studien über Kleinhirncysten, Bau, Pathogenese und Beziehungen zur Angiomatosis retinae. Acta Pathol Microbiol Scand [Suppl] 1: 128
Londrini S, Lasio G, Cimino C, Pluchino F (1991) Hemangioblastomas: clinical characteristics, surgical results and immunohistochemical studies. J Neurosurg Sci 35: 179–185
Meredith JM, Hennigar GR (1954) Cerebellar hemangiomas. Clinicopathologic study of 14 cases. Am Surg 20: 410–420
Mondkar VP, McKissock W, Russel RWR (1967) Cerebellar hemangioblastoma. Brit J Surg 54: 45–49
Montrieul B, Flori B, Gravier JJ (1974) Angioreticulomes du crevelet. Resultats operatoires a distance. Le probléme des formes multiples. Neurochirurgie 20: 223–232
Mulholand SG, Atuk NO, Walzak MP (1969) Familial pheochromocytoma associated with cerebellar hemangioblastoma. JAMA 207: 1709–1711
Nibbelink DW, Peters BH, McCormick WF (1969) On the association of pheochromocytoma and cerebellar hemangioblastoma. Neurology 19: 455–460
Nicol AAM (1957) Lindau's disease in five generations. Ann Hum Genet 22: 7–15
Norlen G (1941) Familial occurrence of angioma. Acta Clin Scand 85: 198–202
Obrador S, Martin-Rodriguez JG (1977) Biological factors involved in the clinical features and surgical management of cerebellar hemangioblastomas. Surg Neurol 7: 79–85
Okarawa SH (1973) Solid cerebellar hemangioblastoma. J Neurosurg 39: 514–518
Olivecrona H (1952) The cerebellar angioreticulomas. J Neurosurg 9: 317–330
Otenasek FM Silber ML (1961) Spinal hemangioma (hemangioblastoma) in Lindau's disease. J Neurosurg 18: 295–300
Palmer JJ (1972) Haemangioblastomas: a review of 81 cases. Acta Neurochir (Wien) 27: 125–148
Pennybacker JB (1954) Recurrence in cerebellar haemangiomas. Zbl Neurochir 1(2): 63–73
Papo I, Colombo F, Dorizzi A (1961) Considerazioni su 45 casi di angioreticulomi dell'encefalo. Minerva Neurochir 592: 100
Perlmutter I, Horrax G, Poppen JL (1950) Cystic hemangioblastomas of the cerebellum. End results in 25 verified cases. Surg Gynecol Obstet 91: 89–99
Pouyanne H, Leman P, Got M, Sallés M (1962) Réflexions sur six cases d'angioreticulomes du cervelet et leur expression angiographique. Neurochirurgie 8: 89–99
Race GL, Finney JW, Mallams JT, Balla GA (1964) Hematopoietic stimulating effect of a cerebellar hemangioblastoma. J Am Med Ass 187: 150–151
Resche F (1985) Les hemangioblastomes infratentoriels. Neurochirurgie 3: 91–149
Rivera E, Chason JL (1966) Cerebral hemangioblastoma. J Neurosurg 25: 452–454
Rochat GF (1931) Großhirnangiom bei der Lindauschen (v. Hippelscher) Erkrankung. Klin Mb1 Augenheilk 86: 23–27
Seeger JF (1981) Computer tomographic and angiographic evaluation of hemangioblastomas. Radiology 138: 65–73
Potondi A (1961) Rosszindulatu a lágyburkok közt terjedö angioblastoma. Ideggyógy. Szemle 14: 1–6
Schmitt J (1972) Phakomatoses-visceral aspects. Handbook of clinical neurology, Vol 14. North Holland, Amsterdam, p 692
Silver ML, Hennigar G (1952) Cerebellar hemangioma (hemangioblastoma). A clinicopathological review of 40 cases. J Neurosurg 9: 484–494
Skultety FM, Sorrel MF, Burklund CW (1970) Haemangioblastoma of the cerebellum associated with erithrocytosis and unusual blood supply. J Neurosurg 32: 700–705
Stein AA, Schilp AO, Whitfield RD (1960) The histogenesis of hemangioblastoma of the brain. J Neurosurg 17: 751–761
Symon L, Murota T, Rell M, Bordi L (1993) Surgical management of hemangioblastoma of the posterior fossa. Acta Neurochir (Wien) 120: 103–110
von Hippel E (1895) Vorstellung eines Patienten mit einer sehr ungewöhnlichen Netzhaut. XXIV Versammlung der Ophtalmologischen Gesellschaft Heidelberg Wiesbaden. Bergmann, p269
Thomas M, Burnsid RM (1961) Von Hippel-Lindau disease. Am J Ophthalmol 51: 140–146
Tonning HO, Warren RF, Barne HJ (1952) Familial haemangiomata of the cerebellum. J Neurosurg 9: 124–132
Tshenzow A (1992) Ein Fall von Angiomatosis retinae. Zbl Ges Ophtalmol 14: 764
Waldmann TA, Levin EH, Baldwin M (1961) The association of polycythemia with a cerebellar hemangioblastoma. Am J Med 31: 318–324
Ward AA Jr, Foltz EL, Knopp LM (1956) “Polycythemia” associated with cerebellar hemangioblastoma. J Neurosurg 13: 248–258
Walker AE, Johnson HC, Browne KM (1952) Hemangiomas of forth ventricle. J Neuropath Exper Neurol 11: 103–115
Wolpert SM (1970) The neuroradiology of hemangioblastomas of the cerebellum. Am J Roent Rad Th Nucl Med 110: 56–66
Wylie IG, Jeffreys RV, Maclaine GN (1973) Cerebral hemangioblastoma. Brit J Radiol 46: 472–476
Yamashita J, Handa H, Kim C, Kim S (1982) Familial occurrence of cerebellar hemangioblastomas: analysis of five families. Neurosurgery 11: 761–763
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Julow, J., Bálint, K., Gortvai, P. et al. Posterior fossa haemangioblastomas. Acta neurochir 128, 109–114 (1994). https://doi.org/10.1007/BF01400659
Issue Date:
DOI: https://doi.org/10.1007/BF01400659