Skip to main content
Log in

Posterior fossa haemangioblastomas

  • Clinical Articles
  • Published:
Acta Neurochirurgica Aims and scope Submit manuscript

Summary

36 consecutive years' experience in treating 104 cases of posterior fossa haemangioblastomas is described and discussed. The mortality was 24%, with a tendency to decrease, reaching 20% in the last 15 years. About half the patients returned to neurological normality and full working capacity. Dividing the lesions into solid and cystic tumours, cystic tumours were more frequent, their survival was longer, recurrence less and postoperative state somewhat better.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Adair LB (1978) Cerebellarhaemangioblastoma: computed tomographic, angiographic and clinical correlations in seven cases. Comput Tomogr 4: 281–294

    Google Scholar 

  2. Babchin IL (1962) On the familial angioreticulomata of the cerebellum. Voprosy Neurochirurgii 26: 54–59

    Google Scholar 

  3. Berblinger W (1992) Zur Auffassung von der sogenannten v. Hippeischen Krankheit der Netzhaut (Capillares Haemangiom im verlängerten Mark) A von Graefes Arch Ophtalmol 110: 395–414

    Google Scholar 

  4. Brandt R (1921) Zur Frage der Angiomatosis retinae. A von Graefes Arch Ophtalmol 106: 127–165

    Google Scholar 

  5. Broager B (1949) Multiple cerebellar angioreticulomas. Discussion of high protein contents of the cysts and of enclosed parts of the subarachnoid space. Acta Psychiatr Neurol Scand 24: 317–332

    PubMed  Google Scholar 

  6. Brody JF, Rodriguez F (1961) Cerebellar hemangioblastoma and polycythemia (erythrocytemia) Am J Med Sci 272: 579–584

    Google Scholar 

  7. Carpenter G, Schwartz HG, Walker AE (1943) Neurogenic polycythemia. Ann Intern Med 19: 470–481

    Google Scholar 

  8. Cramer F, Kimsey WH (1952) The cerebellar haemangioblastoma; review of 53 cases, with special reference to cerebellar cysts and association of polycythemia. Arch Neurol Psychiatry 67: 237–252

    Google Scholar 

  9. Constans JP, Meder F, Maiuri F, Donzelli R, Spaziente R, de Divitiis E (1986) Posterior fossa hemangioblastomas. Surg Neurol 25: 269–275

    PubMed  Google Scholar 

  10. Gushing H, Bailey P (1932) Tumors arising from the blood-vessels of the brain: angiomatous malformations and hemangioblastomas. Thomas, Springfield, Ill

    Google Scholar 

  11. Di Chiro G (1957) Combined retino-cerebellar angiomatosis and deep cervical angiomas: case report. J Neurosurg 14: 685–687

    PubMed  Google Scholar 

  12. Djindjian R, Hurth M, Houdart R (1971) Haemangioblastomes medullaires et maladie de I. Hippel Lindau Rev Neurol 124: 495

    Google Scholar 

  13. Ganti SR, Silver AH, Hilal SH (1982) Computed tomography of cerebellar hemangioblastomas. J Comput Assist Tomogr 6: 912–919

    PubMed  Google Scholar 

  14. Garcia-Bengochea F, Berk M (1965) The so-called solid hemangioblastoma of the cerebellum and vertebral angiography. J Neurosurg 22: 35–39

    PubMed  Google Scholar 

  15. Guerin J, Biulac B, Caillé JM, Pouyanne H (1974) Les hemangioblastomes multiples. Neurochirurgie 20: 565–582

    PubMed  Google Scholar 

  16. Handa J, Miwa Y, Shimizu Y, Handa H (1974) Cerebellar haemangioblastoma with an enlarged tentorial artery. Surg Neurol 2: 55–57

    PubMed  Google Scholar 

  17. Hennessy TG, Stern WE, Herrick SE (1967) Cerebellar hemangioblastoma: erythropoetic activity by radioiron assay. J Nucl Med 8: 601–608

    PubMed  Google Scholar 

  18. Hippel E (1904) Über eine sehr seltene Erkrankung der Netzhaut. Klinische Beobachtungen. Arch J Ophtal 59: 83–106

    Google Scholar 

  19. Iswar S, Tanigochi RM, Vogel FS (1971) Multiple supratentorial haemangioblastomas. J Neurosurg 35: 394–405

    Google Scholar 

  20. Jamieson KG, Yelland JDN, Merry GS (1974) Haemangioblastomas of the hindbrain: a report of 18 cases. Aust NZJ Surg 44: 254–257

    Google Scholar 

  21. Jeffreys R (1975) Clinical and surgical aspects of posterior fossa hemangioblastoma. J Neurol Neurosurg Psychiatry 38: 105–111

    PubMed  Google Scholar 

  22. Hoff JT, Ray BS (1968) Cerebral hemangioblastoma occurring in a patient with von Hippel-Lindau disease. J Neurosurg 28: 365–368

    PubMed  Google Scholar 

  23. Julien PP (1962) Hemangioblastome du cervelet accompagne d'une polycythemie. Un Med Canad 91: 749–752

    Google Scholar 

  24. Julow J, Pásztor E (1975) Cerebellaris haemangioblastoma Id-eggyógy. Szemle 28: 371–376

    Google Scholar 

  25. Kawano T, Iwamoto K, Mori K, Matsuse E (1985) Multicentric hemangioblastomas in the cerebellum. Surg Neurol 24: 677–680

    PubMed  Google Scholar 

  26. Kawafuchi J, Shirakura T, Azuma M, Tsunoda T, Maekawa T (1970) Hematological study on a case with cerebellar hemangioblastoma associated with erythrocytosis, with special reference to a erythropoiesis-with special reference to a erythropoiesis-stimulating activity present in the fluid of the cyst of tumour. Blut 20: 69–75

    PubMed  Google Scholar 

  27. Krayenbühl HA, Yasargil MG (1958) Das Kleinhirnhemangiom. Schweiz Med Wochenschr 88: 99–104

    PubMed  Google Scholar 

  28. Lagré J, Sedan R, Lavielle J, Clement JP, Paillas JE (1968) Maladie de von Hippel-Lindau. Ablation des angioreticulomes cerebelleux et guerison. Etude neuroradiologique avec exploration angiographique selective des localisations viscerales. Neurochirurgie 14: 538–597

    Google Scholar 

  29. Leu HJ, Ruttner JR (1973) Angioretikulome des Zentralnervensystems. Acta Neurochir (Wien) 29: 73–82

    Google Scholar 

  30. Lindau A (1926) Studien über Kleinhirncysten, Bau, Pathogenese und Beziehungen zur Angiomatosis retinae. Acta Pathol Microbiol Scand [Suppl] 1: 128

    Google Scholar 

  31. Londrini S, Lasio G, Cimino C, Pluchino F (1991) Hemangioblastomas: clinical characteristics, surgical results and immunohistochemical studies. J Neurosurg Sci 35: 179–185

    PubMed  Google Scholar 

  32. Meredith JM, Hennigar GR (1954) Cerebellar hemangiomas. Clinicopathologic study of 14 cases. Am Surg 20: 410–420

    PubMed  Google Scholar 

  33. Mondkar VP, McKissock W, Russel RWR (1967) Cerebellar hemangioblastoma. Brit J Surg 54: 45–49

    PubMed  Google Scholar 

  34. Montrieul B, Flori B, Gravier JJ (1974) Angioreticulomes du crevelet. Resultats operatoires a distance. Le probléme des formes multiples. Neurochirurgie 20: 223–232

    PubMed  Google Scholar 

  35. Mulholand SG, Atuk NO, Walzak MP (1969) Familial pheochromocytoma associated with cerebellar hemangioblastoma. JAMA 207: 1709–1711

    PubMed  Google Scholar 

  36. Nibbelink DW, Peters BH, McCormick WF (1969) On the association of pheochromocytoma and cerebellar hemangioblastoma. Neurology 19: 455–460

    PubMed  Google Scholar 

  37. Nicol AAM (1957) Lindau's disease in five generations. Ann Hum Genet 22: 7–15

    PubMed  Google Scholar 

  38. Norlen G (1941) Familial occurrence of angioma. Acta Clin Scand 85: 198–202

    Google Scholar 

  39. Obrador S, Martin-Rodriguez JG (1977) Biological factors involved in the clinical features and surgical management of cerebellar hemangioblastomas. Surg Neurol 7: 79–85

    PubMed  Google Scholar 

  40. Okarawa SH (1973) Solid cerebellar hemangioblastoma. J Neurosurg 39: 514–518

    PubMed  Google Scholar 

  41. Olivecrona H (1952) The cerebellar angioreticulomas. J Neurosurg 9: 317–330

    PubMed  Google Scholar 

  42. Otenasek FM Silber ML (1961) Spinal hemangioma (hemangioblastoma) in Lindau's disease. J Neurosurg 18: 295–300

    PubMed  Google Scholar 

  43. Palmer JJ (1972) Haemangioblastomas: a review of 81 cases. Acta Neurochir (Wien) 27: 125–148

    Google Scholar 

  44. Pennybacker JB (1954) Recurrence in cerebellar haemangiomas. Zbl Neurochir 1(2): 63–73

    Google Scholar 

  45. Papo I, Colombo F, Dorizzi A (1961) Considerazioni su 45 casi di angioreticulomi dell'encefalo. Minerva Neurochir 592: 100

    Google Scholar 

  46. Perlmutter I, Horrax G, Poppen JL (1950) Cystic hemangioblastomas of the cerebellum. End results in 25 verified cases. Surg Gynecol Obstet 91: 89–99

    PubMed  Google Scholar 

  47. Pouyanne H, Leman P, Got M, Sallés M (1962) Réflexions sur six cases d'angioreticulomes du cervelet et leur expression angiographique. Neurochirurgie 8: 89–99

    Google Scholar 

  48. Race GL, Finney JW, Mallams JT, Balla GA (1964) Hematopoietic stimulating effect of a cerebellar hemangioblastoma. J Am Med Ass 187: 150–151

    Google Scholar 

  49. Resche F (1985) Les hemangioblastomes infratentoriels. Neurochirurgie 3: 91–149

    Google Scholar 

  50. Rivera E, Chason JL (1966) Cerebral hemangioblastoma. J Neurosurg 25: 452–454

    PubMed  Google Scholar 

  51. Rochat GF (1931) Großhirnangiom bei der Lindauschen (v. Hippelscher) Erkrankung. Klin Mb1 Augenheilk 86: 23–27

    Google Scholar 

  52. Seeger JF (1981) Computer tomographic and angiographic evaluation of hemangioblastomas. Radiology 138: 65–73

    PubMed  Google Scholar 

  53. Potondi A (1961) Rosszindulatu a lágyburkok közt terjedö angioblastoma. Ideggyógy. Szemle 14: 1–6

    Google Scholar 

  54. Schmitt J (1972) Phakomatoses-visceral aspects. Handbook of clinical neurology, Vol 14. North Holland, Amsterdam, p 692

    Google Scholar 

  55. Silver ML, Hennigar G (1952) Cerebellar hemangioma (hemangioblastoma). A clinicopathological review of 40 cases. J Neurosurg 9: 484–494

    PubMed  Google Scholar 

  56. Skultety FM, Sorrel MF, Burklund CW (1970) Haemangioblastoma of the cerebellum associated with erithrocytosis and unusual blood supply. J Neurosurg 32: 700–705

    PubMed  Google Scholar 

  57. Stein AA, Schilp AO, Whitfield RD (1960) The histogenesis of hemangioblastoma of the brain. J Neurosurg 17: 751–761

    PubMed  Google Scholar 

  58. Symon L, Murota T, Rell M, Bordi L (1993) Surgical management of hemangioblastoma of the posterior fossa. Acta Neurochir (Wien) 120: 103–110

    Google Scholar 

  59. von Hippel E (1895) Vorstellung eines Patienten mit einer sehr ungewöhnlichen Netzhaut. XXIV Versammlung der Ophtalmologischen Gesellschaft Heidelberg Wiesbaden. Bergmann, p269

    Google Scholar 

  60. Thomas M, Burnsid RM (1961) Von Hippel-Lindau disease. Am J Ophthalmol 51: 140–146

    PubMed  Google Scholar 

  61. Tonning HO, Warren RF, Barne HJ (1952) Familial haemangiomata of the cerebellum. J Neurosurg 9: 124–132

    PubMed  Google Scholar 

  62. Tshenzow A (1992) Ein Fall von Angiomatosis retinae. Zbl Ges Ophtalmol 14: 764

    Google Scholar 

  63. Waldmann TA, Levin EH, Baldwin M (1961) The association of polycythemia with a cerebellar hemangioblastoma. Am J Med 31: 318–324

    PubMed  Google Scholar 

  64. Ward AA Jr, Foltz EL, Knopp LM (1956) “Polycythemia” associated with cerebellar hemangioblastoma. J Neurosurg 13: 248–258

    PubMed  Google Scholar 

  65. Walker AE, Johnson HC, Browne KM (1952) Hemangiomas of forth ventricle. J Neuropath Exper Neurol 11: 103–115

    Google Scholar 

  66. Wolpert SM (1970) The neuroradiology of hemangioblastomas of the cerebellum. Am J Roent Rad Th Nucl Med 110: 56–66

    Google Scholar 

  67. Wylie IG, Jeffreys RV, Maclaine GN (1973) Cerebral hemangioblastoma. Brit J Radiol 46: 472–476

    PubMed  Google Scholar 

  68. Yamashita J, Handa H, Kim C, Kim S (1982) Familial occurrence of cerebellar hemangioblastomas: analysis of five families. Neurosurgery 11: 761–763

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Julow, J., Bálint, K., Gortvai, P. et al. Posterior fossa haemangioblastomas. Acta neurochir 128, 109–114 (1994). https://doi.org/10.1007/BF01400659

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01400659

Keywords

Navigation