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Massive Crooke's hyalinization in corticotroph cell adenomas of the human pituitary

A histological, immunocytological, and electron microscopic study of three cases

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Summary

Three women with Cushing's disease caused by ACTH-producing adenoma, underwent transsphenoidal tumour resection. Many adenoma cells showed massive accumulation of microfilaments indistinguishable from Crooke's hyaline material by light and electron microscopy. We believe that these tumours represent variants of ACTH-producing adenomas, and the accumulation of microfilaments is due to cortisol dependency.

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References

  1. Bergland, R. M., Torack, R. M., An ultrastructural study of follicular cells in the human anterior pituitary. Am. J. Path.57 (1969), 273–297.

    PubMed  Google Scholar 

  2. Crcoke, A. C., A change in the basophilic cells of the pituitary gland common to condition which exhibit the syndrome attributed to basophilic adenoma. J. Path. Bact.41 (1935), 339–349.

    Google Scholar 

  3. DeCicco, F. A., Dekker, A., Yunis, E. J., Fine structure of the Crooke's hyaline change in the human pituitary gland. Arch. Path.94 (1972), 65–70.

    PubMed  Google Scholar 

  4. Fisher, M. M., Phillips, M. J., Cytoskeleton of hepatocytes. In: Progress in liver disease, Vol. VI (Popper, H., Schaffner, F., eds.), p. 105. New York-San Francisco-London: Grune and Stratton. 1978.

    Google Scholar 

  5. Halmi, N. S., McCormick, W. F., Decker, D. A., The natural history of hyalization of ACTH-MSH cells in man. Arch. Path.91 (1971), 318–326.

    PubMed  Google Scholar 

  6. Kepler, E. J., The relationship of “Crooke's changes” in the basophilic cells of the pituitary body to Cushing's syndrome (pituitary basophilism). J. Clin. Endocrinol.5 (1945), 70–75.

    Google Scholar 

  7. Kovacs, K., Corenblum, B., Sirek, A. M. T., Penz, G., Ezrin, C., Localization of prolactin in chromophobe pituitary adenomas: Study of human necropsy material by immunoperoxidase technique. J. Clin. Path.29 (1976), 250–258.

    PubMed  Google Scholar 

  8. Kovacs, K., Horvath, E., Stratmann, I. E., Ezrin, C., Cytoplasmic microfilaments in the anterior lobe of the human pituitary. Acta Anat.87 (1976), 414–426.

    Google Scholar 

  9. Kovacs, K., Horvath, E., Bayley, A. T., Hassaram, S. T., Ezrin, C., Silent corticotroph cell adenoma with lysosomal accumulation and crinophagy. Am. J. Med.64 (1978), 492–499.

    PubMed  Google Scholar 

  10. Kovacs, K., Horvath, E., Kerenyi, N. A., Sheppard, R. H., Light and electron microscopic adenomas of the pituitary adenoma in Nelson's syndrome. Am. J. Clin. Pathol.65 (1976), 337–343.

    PubMed  Google Scholar 

  11. Lacy, P. E., Endocrine secretory mechanism: A review. Am. J. Pathol.79 (1975), 170–187.

    PubMed  Google Scholar 

  12. Landolt, A. M., Ultrastructure of the human sella tumors. Acta Neurochir., Suppl. 22, p. 57. Wien-New York: Springer. 1975.

    Google Scholar 

  13. Olivier, L., Vila-Porcile, E., Racadot, O., Peilion, F., Racadot, J., Ultrastructure of the pituitary tumor cells: A critical study. In: The anterior pituitary, Vol. 7 (Tixier-Vidal, A., Farquhar, M. G., eds.), pp. 231–276. New York: Academic Press. 1975.

    Google Scholar 

  14. Ostlund, R. E., Jr., Leung, J. T., Kipnis, D. M., Muscle actin filaments bind pituitary secretory granules in vitro. J. Cell Biol.73 (1977), 78–87.

    PubMed  Google Scholar 

  15. Ostlund, R. E., Jr., Contractil proteins and pancreatic secretion. Diabetes26 (1977), 245–254.

    PubMed  Google Scholar 

  16. Porcile, E., Racadot, J., Ultrastructure des cellules de Crooke observées dans l'hypophyse humaine au cours de la maladie de Cushing. C. R. Acad. Sci. (Paris)263 (1966), 948–951.

    Google Scholar 

  17. Robert, F., Pelletier, G., Hardy, J., Pituitary adenomas in Cushing's disease; a histological ultrastructural and immunocytochemical study. Arch. Path. Lab. Med.102 (1978), 448–455.

    PubMed  Google Scholar 

  18. Spencer, P. S., Schaumburg, H. H., Pathobiology of neurotoxic axonal degeneration. In: Physiology and pathobiology of the axons (Waxman, S. G., ed.), pp. 265–282. New York: Raven Press. 1978.

    Google Scholar 

  19. Spooner, B. S., Yamada, K. M., Wessells, N. K., Microfilaments and cell locomotion. J. Cell Biol.49 (1971), 595–613.

    PubMed  Google Scholar 

  20. Wagermark, J., Wersall, J., Ultrastructural features of Crooke's changes in pituitary basophil cells. Acta Pathol. Microbiol. Scand.72 (1968), 367–375.

    PubMed  Google Scholar 

  21. Warner, T. S. C. F., Seo, I. S., Aggregates of cytofilaments as the cause of the appearance of hyaline tumor cells. Ultrastruct. Pathol.1 (1980), 395–401.

    PubMed  Google Scholar 

  22. Wisniewski, H., Terry, R., Hirano, A., Neurofibrillary pathology. J. Neuropath. exp. Neurol.29 (1970), 163–175.

    PubMed  Google Scholar 

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Author notes

  1. I. A. Felix

    Present address: Department of Pathology, Hospital “20 de Noviembre” (ISSSTE), av. coyoacan y Felix Cuevas, Colonia del Valle, Mexico 12, D.F., Mexico

Authors and Affiliations

  1. Department of Pathology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada

    I. A. Felix, E. Horvath & K. Kovacs

Authors
  1. I. A. Felix
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  2. E. Horvath
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  3. K. Kovacs
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Additional information

Research fellow supported by Conacyt and Hospital 20 de Noviembre (ISSSTE), Department of Pathology, Mexico D.F., Mexico.

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Felix, I.A., Horvath, E. & Kovacs, K. Massive Crooke's hyalinization in corticotroph cell adenomas of the human pituitary. Acta neurochir 58, 235–243 (1981). https://doi.org/10.1007/BF01407130

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