Abstract
In the chicken, the cranial and caudal parathyroid glands (parathyroid gland III and IV), which are connected to each other, are located adjacent to the carotid body. In the present study, we found that a mass of glomus cells surrounded by a thick layer of connective tissue was frequently distributed within the parathyroid gland III. The glomus cells in the parathyroid III, as well as those of the carotid body, expressed intense immunoreactivity for serotonin, chromogranin A, and tyrosine hydroxylase but no immunoreactivity for neuropeptide Y. The cells possessed long cytoplasmic processes containing dense-cored vesicles of 70–220 nm in diameter, and were in close association with sustentacular cells. In and around the glomus cell clusters of the parathyroid III, dense networks of varicose fibers showed immunostaining with the monoclonal antibody TuJ1 to a neuronspecific class III β-tubulin isotype, cβ4. Furthermore, the distribution was also detected of numerous galanin-, vasoactive intestinal peptide (VIP)-, substance P-, and calcitonin gene-related peptide (CGRP)-immunoreactive fibers.
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Chen IL, Yates RD (1970) Ultrastructural studies of vagal paraganglia in Syrian hamsters. Z Zellforsch 108:309–323
Dahlqvist Å, Hellström S, Carlsöö B, Pequignot JM (1987) Paraganglia of the rat recurrent laryngeal nerve after long-term hypoxia: a morphometric and biochemical study. J Neurocytol 16:289–297
Easter SS Jr, Ross LS, Frankfurter A (1993) Initial tract formation in the mouse brain. J Neurosci 13:285–299
Easton J, Howe A (1983) The distribution of thoracic glomus tissue (aortic bodies) in the rat. Cell Tissue Res 232:349–356
Hansen JT (1978) Development of type I cells of the rabbit subclavian glomera (aortic bodies): a light, fluorescence and electron microscopic study. Am J Anat 153:15–32
Kameda Y (1987) Localization of immunoreactive calcitonin gene-related peptide in thyroid C cells from various mammalian species. Anat Rec 219:204–212
Kameda Y (1989a) Occurrence of calcitonin-positive C cells within the distal vagal ganglion and the recurrent laryngeal nerve of the chicken. Anat Rec 224:43–54
Kameda Y (1989b) Distribution of CGRP-, somatostatin-, galanin-, VIP-, and substance P-immunoreactive nerve fibers in the chicken carotid body. Cell Tissue Res 257:623–629
Kameda Y (1990a) Distribution of serotonin-immunoreactive cells around arteries arising from the common carotid artery in the chicken. Anat Rec 227:87–96
Kameda Y (1990b) Innervation of the serotonin-immunoreactive cells distributed in the wall of the common carotid artery and its branches in the chicken. J Comp Neurol 292:537–550
Kameda Y (1990c) Ontogeny of the carotid body and glomus cells distributed in the wall of the common carotid artery and its branches in the chicken. Cell Tissue Res 261:525–537
Kameda Y (1991) Immunocytochemical localization and development of multiple kinds of neuropeptides and neuroendocrine proteins in the chick ultimobranchial gland. J Comp Neurol 304:373–386
Kameda Y (1994) Electron microscopic study on the development of the carotid body and glomus cell groups distributed in the wall of the common carotid artery and its branches in the chicken. J Comp Neurol 348:544–555
Kameda Y, Okamoto K, Ito M, Tagawa T (1988) Innervation of the C cells of chicken ultimobranchial glands studied by immunohistochemistry, fluorescence microscopy, and electron microscopy. Am J Anat 182:353–368
Kameda Y, Amano T, Tagawa T (1990) Distribution and ontogeny of chromogranin A and tyrosine hydroxylase in the carotid body and glomus cells located in the wall of the common carotid artery and its branches in the chicken. Histochemistry 94:609–616
Kameda Y, Yamatsu Y, Kameya T, Frankfurter A (1994) Glomus cell differentiation in the carotid body region of chick embryos studied by neuron-specific class III β-tubulin isotype and Leu-7 monoclonal antibodies. J Comp Neurol 348:531:543
Kondo H (1974) On the granule containing cells in the aortic wall of the young chick. Anat Rec 178:253–266
Kondo H (1975) A light and electron microscopic study on the embryonic development of the rat carotid body. Am J Anat 144:275–294
Kummer W, Addicks K (1982) The paraganglion supracardiale vagi: an intravagal paraganglion in the rat. Cell Tissue Res 224:455–458
Matsuura S (1973) Chemoreceptor properties of glomus tissue found in the carotid region of the cat. J Physiol 235:57–73
McDonald DM, Blewett RW (1981) Location and size of carotid body-like organs (paraganglia) revealed in rats by the permeability of blood vessels to Evans blue dye. J Neurocytol 10:607–643
Moody SA, Quigg MS, Frankfurter A (1989) Development of the peripheral trigeminal system in the chick revealed by an isotype-specific anti-beta-tubulin monoclonal antibody. J Comp Neurol 279:567–580
Ookawara S, Suzuki K, Yoshida Y, Ooneda G (1974) Monoaminestoring cells in the media of the thoracic aorta ofGallus domesticus. Cell Tissue Res 151:309–316
Sullivan KF, Havercroft JC, Machlin PS, Cleveland DW (1986) Sequence and expression of the chicken β5- and β4-tubulin genes define a pair of divergent β-tubulins with complementary patterns of expression. Mol Cell Biol 6:4409–4418
Watzka M, Scharf JH (1951) Die Paraganglien am Ganglion nodosum vagi und dessen Umgebung beim erwachsenen Menschen. Z Zellforsch 36:141–150
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Yamatsu, Y., Kameda, Y. Accessory carotid body within the parathyroid gland III of the chicken. Histochem Cell Biol 103, 197–204 (1995). https://doi.org/10.1007/BF01454024
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DOI: https://doi.org/10.1007/BF01454024