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Assessment of various factors influencing esophageal pressure measurement

II. Significance of physiological factors in intraluminal manometry

Der Einfluß verschiedener Faktoren auf die Ösophagusdruckmessung

II. Bedeutung physiologischer Faktoren für die intraluminale Manometrie

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Zusammenfassung

In dem zweiten Teil der Studie wurde der Einfluß von Alter, Geschlecht, Körpergröße, Körpergewicht und Tageszeit (morgens/mittags) auf das Ergebnis der Ösophagusdruckmessung bei insgesamt 119 gesunden Probanden mit einem elektromagnetischen Mikrotransducer untersucht. Weiterhin wurde die intraindividuelle Variabilität der Drucke bei Langzeitbeobachtung im Verlauf von 6 Monaten erfaßt. Von den untersuchten Faktoren beeinflußte nur das Lebensalter die Drucke im oberen Ösophagussphinkter (OÖS) signifikant: Die OÖS-Ruhedrucke der 20- bis 49jährigen Probanden waren im Mittel mit 144,4±8,6 mmHg\((\bar x \pm SEM)\) höher als die der 50- bis 80jährigen, bei denen 103,4±7,2mmHg gemessen wurde (p<0,0005). Die intraindividuelle Variabilität der Drucke im unteren Ösophagussphinkter (UÖS) war beträchtlich, überschritt jedoch nur in wenigen Fällen die als normal definierten (M±2 S) Grenzen. Die Untersuchung zeigt, daß Lebensalter, Geschlecht, Körpergröße und-gewicht die für eine quantitative manometrische Methode ermittelten Normalwerte nicht signifikant beeinflussen. Bei der OÖS-Manometrie muß dagegen der verminderte Tonus beim älteren Patienten berücksichtigt werden.

Summary

In the second part of this study the effect of age, sex, body size, body weight and timing of the manometric examination (morning vs. noon) on esophageal pressure measurement was investigated in a total of 119 healthy subjects, using an electromagnetic microtransducer. Additionally intraindividual variation of pressures was studied over a period of 6 months. Of these parameters only age influenced upper esophageal sphincter (UES) pressure significantly: The mean UES pressure of younger subjects (20–49 years) was significantly higher (144.4±8.6 mmHg) compared to that of older subjects (50–80 years) where a mean pressure of 103.4±7.2 mmHg was recorded (p<0.0005). Intraindividual variation of pressures in the lower esophageal sphincter (LES) was considerable but exceeded only in a few cases the normal pressure range which was defined as M±2 S. The results indicate that age, sex, different body weight and body size do not influence significantly the normal values obtained by a quantitative manometric method. In UES manometry however, the diminished resting pressure in the older patient must be taken into account.

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Authors and Affiliations

  1. I. Medizinische Klinik and Poliklinik, University of Mainz, Germany

    T. R. Weihrauch, P. Vallerius, H. Alpers & K. Ewe

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  1. T. R. Weihrauch
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  2. P. Vallerius
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  3. H. Alpers
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  4. K. Ewe
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To Prof. Dr. H.P. Wolff on the occasion of his 65th birthday

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Weihrauch, T.R., Vallerius, P., Alpers, H. et al. Assessment of various factors influencing esophageal pressure measurement. Klin Wochenschr 58, 287–292 (1980). https://doi.org/10.1007/BF01476570

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  • DOI: https://doi.org/10.1007/BF01476570

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