Summary
Forty milligrams saccharated iron oxide1 was given intravenously, daily, to nine iron-deficient patients with moderate to severe anemia. During the 14–42 days of treatment, levels of serum inorganic phosphorus (Pi) decreased significantly and in a stepwise manner (before vs 1 week,P<0.005; 1 week vs 2 weeks,P<0.01). Seven of the nine patients became hypophosphatemic within 2 weeks and the other two within 4 weeks. In parallel with the decline in serum Pi, the phosphate clearance increased and tubular reabsorption of phosphate decreased. Reversion to normal levels was delayed in patients treated for the longer period.
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Okada, M., Imamura, K., Iida, M. et al. Hypophosphatemia induced by intravenous administration of saccharated iron oxide. Klin Wochenschr 61, 99–102 (1983). https://doi.org/10.1007/BF01496662
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DOI: https://doi.org/10.1007/BF01496662