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Structural gene encoding human factor XII is located at 5q33-qter

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Somatic Cell and Molecular Genetics

Abstract

The gene encoding human factor XII (F12 ) or Hageman factor has been mapped to 5q33-qter. This has been achieved by analyzing the results obtained from hybridizing a cloned fragment from the factor XII gene to a panel of human-hamster somatic cell hybrid DNAs and also by in situ hybridization to normal human metaphase cells. The previously reported results localizingF12 to 6p23 are discussed.

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Literature cited

  1. Fujikawa, K., and Davie, E.W. (1981).Methods Enzymol 80:198–211.

    PubMed  Google Scholar 

  2. Kaplan, A.P. (1978).Prog. Hemostasis Throm. 4:127–175.

    Google Scholar 

  3. Griffin, J.H., and Cochrane, C.G. (1979).Semin. Thromb. Hemostasis 5:254–273.

    Google Scholar 

  4. Ratnoff, O.D., and Saito H. (1979).Curr. Top. Hematol. 2:1–57.

    PubMed  Google Scholar 

  5. Colman, R.W. (1984).J. Clin. Invest. 73:1249–1253.

    PubMed  Google Scholar 

  6. Sealy, J.E., Atlas, S.A., Laragh, J.H., Silverberg, M., and Kaplan, A.P. (1979).Proc. Natl. Acad. Sci. U.S.A. 76:5914–5918.

    PubMed  Google Scholar 

  7. Gordon, E.M., Donaldson, V.H. Saito, H., Su, E., and Ratnoff, O.D. (1981).Ann. Intern. Med. 95:697–700.

    PubMed  Google Scholar 

  8. McKusick, V.A. (1983). Mendelian Inheritance in Man. Catalogues of Autosomal Dominant, Autosomal Recessive and X-Linked Phenotypes, 6th ed, (The John Hopkins University Press, Baltimore).

    Google Scholar 

  9. Hiemark, R.L., Kurachi, K., Fujikawa, K., and Davie, E.W. (1980).Nature 286:456–460.

    PubMed  Google Scholar 

  10. McMillin, C.R., Saito, H., Ratnoff, O.D., and Walton, A.G. (1974).J. Clin. Invest. 54:1312–1322.

    PubMed  Google Scholar 

  11. Saito, H. (1977).J. Clin. Invest. 60:584–594.

    PubMed  Google Scholar 

  12. Fujikawa, K., and McMullen, B.A. (1983).J. Biol. Chem. 258:10924–10933.

    PubMed  Google Scholar 

  13. McMullen, B.A., and Fujikawa, K. (1985).J. Biol. Chem. 260:5328–5341.

    PubMed  Google Scholar 

  14. Cool, D.E., Edgell, C.-J.S., Louie, G.V., Zoller, M.J., Brayer, G.D., and MacGillivray, R.T.A. (1985).J. Biol. Chem. 260:13666–13676.

    PubMed  Google Scholar 

  15. DeGrouchy, J., and Turleau, C., (1974).Humangenetik 24:191–195.

    PubMed  Google Scholar 

  16. Biederman, B., and Bowen, P. (1978).Hum. Genet. 41:101–107.

    PubMed  Google Scholar 

  17. Friedrich U., Osterballe, O., Stenbjerg, S., and Jorgensen, J. (1979).Hum. Genet. 51:231–235.

    PubMed  Google Scholar 

  18. Bernstein, R., Dawson, B., Morcom, G., Wagner, J., and Jenkins, T. (1980).Clin. Genet. 17:228–237.

    PubMed  Google Scholar 

  19. Kawashima, H., and Taniguchi, N. (1981).Clin. Genet. 19:207–208.

    PubMed  Google Scholar 

  20. Mattei, M.G., Arnolds, M., Juhan, I., Rebuffel, P., Mattei, J.F., and Giraud, F. (1981).Cytogenet. Cell Genet. 32:296A.

    Google Scholar 

  21. Pearson, P.L., van der Kamp, J., and Veldtkamp, J. (1981).Cytogenet. Cell. Genet. 32:309A.

    Google Scholar 

  22. Niebuhr, E., Eiberg, H., and Schousboe, I. (1985).Cytogenet. Cell. Genet. 40:714A.

    Google Scholar 

  23. Cool, D.E., and MacGillivray, R.T.A. (1987).J. Biol. Chem. 262:13662–13673.

    PubMed  Google Scholar 

  24. Maniatis, T., Fritsch, E.F., and Sambrook, J. (1982). Molecular Cloning, A Laboratory Manual, (Cold Spring Harbor Laboratories, Cold Spring Harbor, New York).

    Google Scholar 

  25. Donald, J.L., Wang, H.S., Kamali, V., Liebert, L., Rudner-Marion, M., Cameron, E.S., Riddell, D.C., Vust, A., Wrogemann, K., and Hamerton, J.L. (1983).Cytogenet. Cell Genet. 37:453A.

    Google Scholar 

  26. Feinberg, A.P., and Vogelstein, B. (1984).Anal. Biochem. 137:266–267.

    PubMed  Google Scholar 

  27. Royle, N.J., Irwin, D.M., Koschinsky, M.L., MacGillivray, R.T.A., and Hamerton, J.L. (1987).Somat. Cell Mol. Genet. 13:285–292.

    PubMed  Google Scholar 

  28. Harper, M.A., and Saunders, G.F. (1981).Chromosoma 83:431–439.

    PubMed  Google Scholar 

  29. Lin, C.C., Draper, P.N., and DeBrackeleer, M. (1985).Cytogenet. Cell Genet. 39:269–274.

    PubMed  Google Scholar 

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Author notes

  1. N. J. Royle

    Present address: Department of Genetics, University of Leicester, England

Authors and Affiliations

  1. Department of Human Genetics, University of Manitoba, Canada

    N. J. Royle, M. Nigli & J. L. Hamerton

  2. Department of Biochemistry, University of British Columbia, Canada

    D. Cool & R. T. MacGillivray

Authors
  1. N. J. Royle
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  2. M. Nigli
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  3. D. Cool
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  4. R. T. MacGillivray
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  5. J. L. Hamerton
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Royle, N.J., Nigli, M., Cool, D. et al. Structural gene encoding human factor XII is located at 5q33-qter. Somat Cell Mol Genet 14, 217–221 (1988). https://doi.org/10.1007/BF01534407

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  • DOI: https://doi.org/10.1007/BF01534407

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