Abstract
Thirty-two cases of nasopharyngeal angiofibroma, including 2 recurrences, all of which had been excised from males between 7 and 25 years, were subjected to systematic immunohistochemical study. Most of the tumour vessels, which lacked elastic laminae, were characterized by vascular walls of irregular thickness and variable muscle content. In places endothelial cells were only separated from the stroma by a single attenuated layer of contractile cells, whereas elsewhere the same vessel walls showed pad-like thickenings of their muscle coat. All cells of the vessel walls showed immunoreactivity for vimentin and smooth muscle actin, whereas desmin-positive cells were present only in small numbers in some vessels, generally those with thicker muscle coats. The stromal cells were decorated by vimentin antibodies only; however, in some more fibrotic hyaline areas the stromal cells displayed also reactivity for smooth muscle actin. In most cases S-100 protein-staining disclosed many nerves, and this accentuated their partial distortion by tumour tissue. Our findings provide an extended insight to the morphology of angiofibromas at this site, particularly highlighting the irregularity of their vascular walls, which, taken together with the lack of elastic laminae and elastic stromal fibres, can be held responsible for the typical pronounced tendency for haemorrhage in these lesions.
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Referenceds
Arnold W, Huth F (1978) Electron microscopic findings in four cases of nasopharyngeal fibroma. Virchows Arch [A] 379:285–298
Bremer JW, Neel HB, DeSanto LW, Jones GC (1986) Angiofibroma: treatment trends in 150 patients during 40 years. Laryngoscope 96:1321–1329
Enzinger FM, Weiss SW (1988) Soft tissue tumours. C.V. Mosby, St. Louis, pp 127–129
Kocher O, Gabbiani G (1986) Cytoskeletal features of normal and atheromatous human arterial smooth muscle. Hum Pathol 17:875–880
Kumagami H (1991) Testosterone and estradiol in juvenile angiofibroma tissue. Acta Otolaryngol Stockh 111:569–573
Neel HB, Whicker JH, Devine KD, Weiland LH (1973) Juvenile angiofibroma. Review of 120 cases. Am J Surg 126:547–556
Osborn M, Caselitz J, Püschel K, Weber K (1987) Intermediate filament expression in human vascular smooth muscle and in arteriosclerotic plaques. Virchows Arch [A] 411:449–458
Schiff M, Gonzalez AM, Ong M, Baird A (1992) Juvenile nasopharyngeal angiofibroma contain an angiogenic growth factor: basic FGF. Laryngoscope 102:940–945
Skalli O, Gabbiani G (1990) The biology of the myofibroblast and its relation to the development of soft tissue and epithelial tumours. In: Fletcher CDM, McKee PH (eds) Pathobiology of soft tissue tumours. Churchill Livingstone, Edinburgh, pp 83–103
Skalli O, Ropraz P, Trzeciak A, Benzonana G, Gillessen D, Gabbiani G (1986) A monoclonal antibody againstα-smooth muscle actin: A new probe for smooth muscle differentiation. J Cell Biol 103:2787–2796
Skalli O, Pelte MF, Peclet MC, Gabbiani G, Gugliotta P, Bussolati G, Ravazzola M, Orci L (1989a)α-smooth muscle actin, a differentiation marker of smooth muscle cells is present in microfilamentous bundles of pericytes. J Histochem Cytochem 37:315–321
Skalli O, Schurch W, Seemayer TA, Lagace R, Montandon D, Pittet B, Gabbiani G (1989b) Myofibroblasts from diverse pathological settings are heterogeneous in their content of actin isoforms and intermediate filament proteins. Lab Invest 60:275–285
Stiller D, Küttner K (1988) Wachstumsmuster juveniler Nasenrachenfibrome. Eine histologische Analyse anhand von 40 Fällen. Zentralbl Allg Pathol 134:409–422
Stiller D, Katenkamp D, Küttner K (1976) Cellular differentiations and structural characteristics in nasopharyngeal angiofibromas. Virchows Arch [A] 371:273–282
Svoboda DJ, Kirchner F (1966) Ultrastructure of nasopharyngeal angiofibromas. Cancer 19:1949–1962
Taxy JB (1977) Juvenile nasopharyngeal angiofibroma. An ultrastructural study. Cancer 39:1044–1054
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Beham, A., Fletcher, C.D.M., Kainz, J. et al. Nasopharyngeal angiofibroma: An immunohistochemical study of 32 cases. Vichows Archiv A Pathol Anat 423, 281–285 (1993). https://doi.org/10.1007/BF01606891
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DOI: https://doi.org/10.1007/BF01606891