Summary
Two autopsy cases with multiple hepatic metastases of pancreatic endocrine tumours and nodular regenerative hyperplasia of the liver (NRH) are reported. The tumour cells were positive for glucagon, insulin, gastrin and vasoactive intestinal polypeptide immunohistochemically and the serum gastrin was elevated in one case. In the other, tumour cells were positive for insulin. Controls failed to show NRH in the non-metastatic part of 35 autopsies of livers with multiple hepatic metastases. A combination of hepatotrophic hormonal factor(s) and disturbed hepatic circulation associated with hepatic metastases may be important in the development of NRH.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
De Sousa JM, Portmann B, Williamms R (1991) Nodular regenerative hyperplasia of the liver and the Budd-Chiari syndrome. J Hepatol 12:28–35
Harada A, Nakanuma Y, Govindarajan S, Peters R (1986) Nodular regenerative hyperplasia of the liver with and without portal hypertention: a comparison. Ann Clin Lab Sci 6:155–162
Hsu M, Raine L, Fanger H (1981) Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabelled (PAP) procedures. J Histochem Cytochem 29:557–580
Leffert HL, Koch KS, Lad PJ, Skelly H, DeHemptinne B (1982) Hepatocyte regeneration, replication and differentiation. In: Arias I, Popper H, Schachter D, Shafritz DA (eds) The liver: biology and pathobiology. Raven Press, New York, pp 601–614
Lloyd RV, Jin L, Fields K (1990) Detection of chromogranins A and B in endocrine tissues with radioactive and biotinylated oligonucleotide probes. Am J Surg Pathol 14:35–43
Miyai K, Bonin ML (1980) Nodular regenerative hyperplasia of the liver. Am J Clin Pathol 73:267–271
Moran CA, Mullick FG, Ishak KG (1991) Nodular regenerative hyperplasia of the liver in children. Am J Surg Pathol 15:449–454
Nakanuma Y (1990) Nodular regenerative hyperplasia of the liver: retrospective survey in autopsy series. J Clin Gastroenterol 12:460–465
Nakanuma Y, Ohta G, Sasaki K (1984) Nodular regenerative hyperplasia of the liver associated with polyarteritis nodosa. Arch Pathol Lab Med 108:133–135
Ranstrom S (1953) Miliary hepatocellular adenomatosis. Acta Pathol Microbiol Scand 33:225–229
Steiner PE (1959) Nodular regenerative hyperplasia of the liver. Am J Pathol 35:943–953
Straus EW, Raufman JP (1985) Regulatory system polypeptides. In: Haubrich WS, Kalser MH, Roth JA, Schaffner F (eds) Bockus Gastroenterology. Saunders, Philadelphia, pp 4467–4486
Stromeyer FW, Ishak KG (1981) Nodular transformation (nodular “regenerative” hyperplasia) of the liver. A clinicopathologic study of 30 cases. Hum Pathol 12:60–71
Thung SN, Gerber MA, Bodenheimer HC (1982) Nodular regenerative hyperplasia of the liver in a patient with diabetes mellitus. Cancer 49:543–546
Wanless IR (1990) Micronodular transformation (nodular regenerative hyperplasia) of the liver: a report of 64 cases among 2500 autopsies and a new classification of benign hepatocellular nodules. Hepatology 11:787–797
Wanless IR, Godwin TA, Allen F (1980) Nodular regenerative hyperplasia of the liver in hematologic disorders. Medicine 59:367–379
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Minato, H., Nakanuma, Y. Nodular regenerative hyperplasia of the liver associated with metastases of pancreatic endocrine tumour: Report of two autopsy cases. Vichows Archiv A Pathol Anat 421, 171–174 (1992). https://doi.org/10.1007/BF01607051
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01607051