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Accidental amikacin overdose in man: Emergency therapy by extrarenal dialysis

Akzidentelle Amikacin-Überdosierung beim Menschen. Notfalltherapie mit extrarenaler Dialyse

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Summary

Three accidental overdoses of amikacin (6, 6.5 and 8 times the normal dose) are reported. Emergency haemodialysis therapy was given and the serum levels monitored. No toxic effects were encountered. The need for such emergency haemodialysis seems to be limited to patients with impaired renal function or to cases where little time has elapsed between intake and detection of overdose.

Zusammenfassung

Drei Fälle von akzidenteller Amikacin-Überdosierung (sechs-, sechseinhalb-und achtfache Dosis) werden mitgeteilt. Die Notfalltherapie wurde mit Hämodialyse durchgeführt, dabei wurden die Serumspiegel überwacht. Toxische Wirkungen wurden nicht festgestellt. Die Notwendigkeit einer solchen Notfall-Hämodialyse scheint auf Patienten mit eingeschränkter Nierenfunktion oder auf Fälle, bei denen zwischen Medikamentengabe und Feststellung der Überdosierung nur wenig Zeit verstrichen ist, begrenzt zu sein.

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Authors and Affiliations

  1. Laboratoire de Bactériologie-Virologie, Faculté de Médecine alexis Carrel, Rue Guillaume Paradin, F-69008, Lyon, France

    J. P. Flandrois

  2. Hôpital Edouard Herriot, F-69374, Lyon, France

    P. Bouletreau,  C. Auboyer,  R. Muchada,  R. Ducluzeau &  J. Etienne

Authors
  1. J. P. Flandrois
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  2. P. Bouletreau
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  3. C. Auboyer
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  4. R. Muchada
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  5. R. Ducluzeau
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  6. J. Etienne
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Flandrois, J.P., Bouletreau, P., Auboyer, C. et al. Accidental amikacin overdose in man: Emergency therapy by extrarenal dialysis. Infection 7, 190–191 (1979). https://doi.org/10.1007/BF01640943

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  • DOI: https://doi.org/10.1007/BF01640943

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