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Einfluß einer adjuvanten Immunglobulintherapie auf Infektionen bei Patienten einer operativen Intensiv-Therapie-Station

Therapeutic effects of immunoglobulin in intensive care patients with severe infections

Ergebnisse einer randomisierten kontrollierten Studie

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Summary

A randomized controlled clinical trial was conducted on the effects of immunoglobulin in therapy for infections in 104 intensive care patients. At the first sign of infection, one group of 50 patients received an i.v. preparation of immunoglobulin (4×100 ml) combined with antibiotics. The other 54 control patients received antibiotics alone. The most common infections in these patients were pneumonia, septicemia, peritonitis and wound sepsis. Infections were significantly seldom the cause of death, especially in patients with high-risk surgery who had been treated with immunoglobulin (p≤0.05). Likewise ventilation time in the high-risk surgery group averaged only 5.5 days for those receiving immunoglobulin as opposed to 12.7 days in controls (p≤0.01). Whereas the control group, in particular patients with pneumonia, remained in intensive care an average of 21.5 days, those receiving immunoglobulin stayed only 14.8 days (p≤0.01). In general, patients treated with immunoglobulin recovered more rapidly from infections than did controls (p≤0.01).

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Abbreviations

BKS:

Blutkörperchensenkungsgeschwindigkeit

Diff-BB:

Differentialblutbild

EDV:

Elektronische Datenverarbeitung

Hb:

Hämoglobin

Hkt:

Hämatokrit

IgA, M, G:

Immunglobulin der Klasse A, M, G

IPS:

Intensivpflegestation

Koag. pos./neg.:

Koagulase positiv/negativ

G:

Gesamtgruppe

Ü:

Überlebende

V:

Verstorbene

R0–R3:

Risikogruppen 0–3

S:

Sepsispatienten

P:

Pneumoniepatienten

PTT:

partial thromboplastin time

S.D.:

Standardabweichung

SGPT:

Serum-Glutamat-pyruvat-transaminase

SGOT:

Serum-Glutamat-oxalazetat-transaminase

SPSS:

Statistical package for the social science

ZVD:

Zentraler Venendruck

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Authors and Affiliations

  1. Klinikhygiene, Universitätslinik Freiburg, Germany

    H. -M. Just & M. Metzger

  2. Institut für Anästhesiologie, Universitätsklinik Freiburg, Germany

    W. Vogel

  3. Lehrstuhl für Angewandte Statistik und EDV an der Universität der Bundeswehr München, Germany

    R. B. Pelka

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  1. H. -M. Just
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  2. M. Metzger
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  3. W. Vogel
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  4. R. B. Pelka
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Just, H.M., Metzger, M., Vogel, W. et al. Einfluß einer adjuvanten Immunglobulintherapie auf Infektionen bei Patienten einer operativen Intensiv-Therapie-Station. Klin Wochenschr 64, 245–256 (1986). https://doi.org/10.1007/BF01711930

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  • DOI: https://doi.org/10.1007/BF01711930

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