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Sequence comparison of the VP7 gene encoding the outer capsid glycoprotein among animal and human group C rotaviruses

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Summary

The nucleotide sequences of the outer capsid glycoprotein (VP7) genes from the Shintoku bovine and the HF and WH porcine group C rotaviruses were determined and compared with those of the published corresponding genes from the Cowden porcine and Ehime human group C rotaviruses. The VP7 genes of all 5 strains were 1063 nucleotides in length and possess one open reading frame encoding a polypeptide of 332 amino acids. Comparative analysis of the deduced amino acid sequences indicated that 85.2–97.0% identity was observed for the VP7 of the serotypically related strains of group C rotaviruses (Cowden, WH and Ehime) whereas 69.9–74.7% identity was observed among the serotypically distinct strains (Shintoku; Cowden, WH and Ehime; and HF). At least 8 variable regions in the VP7 were recognized among serotypically distinct strains, and these locations were similar to those of the variable regions in the VP7 of group A rotaviruses.

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Author notes

  1. H. Tsunemitsu

    Present address: Hokkaido Branch, National Institute of Animal Health, Sapporo, Hokkaido, Japan

  2. B. Jiang

    Present address: The Wyeth-Lederle Vaccines and Pediatrics Division, American Home Products Corporation, West Henrietta, New York, USA

Authors and Affiliations

  1. Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, USA

    H. Tsunemitsu & L. J. Saif

  2. Viral Gastroenteritis Section, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

    B. Jiang

Authors
  1. H. Tsunemitsu
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  2. B. Jiang
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  3. L. J. Saif
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Tsunemitsu, H., Jiang, B. & Saif, L.J. Sequence comparison of the VP7 gene encoding the outer capsid glycoprotein among animal and human group C rotaviruses. Archives of Virology 141, 705–713 (1996). https://doi.org/10.1007/BF01718328

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  • DOI: https://doi.org/10.1007/BF01718328

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