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A breast cancer nutrition adjuvant study (NAS): Protocol design and initial patient adherence

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Abstract

To evaluate the feasibility of using a reduction in dietary fat intake as a component of treatment regimens for patients with resected breast cancer, a multi-disciplinary cooperative group protocol was developed. Females 50 to 75 years of age with stage II breast cancer who completed primary local therapy were eligible for randomization to a Control Dietary Group in which dietary fat intake was to remain unchanged from baseline level (at approximately 38% of calories derived from fat) and an Intensive Intervention Dietary Group designed to reduce dietary fat intake. Both Dietary Groups were given tamoxifen 20 mg/day. To facilitate early experience with dietary regimen delivery, patients entered during an initial pilot phase could receive any chemotherapy and/or hormonal treatment. A prerandomization nutrition ‘run-in’ of clinically eligible patients assessed adherence to nutrition data collection procedures and screened patients for nutrition eligibility criteria. Of 59 patients beginning ‘run-in’, 49 were randomized and, at present, 32 have completed at least three months follow-up. The change in dietary fat intake (as assessed by Four Day Food Records) seen in both arms is outlined below.

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Authors and Affiliations

  1. The UCLA School of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA

    Rowan T. Chlebowski, Daniel W. Nixon, George L. Blackburn, Peter Jochimsen, Edward F. Scanlon, William Insull Jr, I. Marilyn Buzzard, Robert Elashoff, Ritva Butrum & Ernst L. Wynder

  2. Emory University, Atlanta, GA, USA

    Rowan T. Chlebowski, Daniel W. Nixon, George L. Blackburn, Peter Jochimsen, Edward F. Scanlon, William Insull Jr, I. Marilyn Buzzard, Robert Elashoff, Ritva Butrum & Ernst L. Wynder

  3. New England Deaconess Hospital, Boston, MA, USA

    Rowan T. Chlebowski, Daniel W. Nixon, George L. Blackburn, Peter Jochimsen, Edward F. Scanlon, William Insull Jr, I. Marilyn Buzzard, Robert Elashoff, Ritva Butrum & Ernst L. Wynder

  4. University of Iowa Hospitals, Iowa City, Iowa, USA

    Rowan T. Chlebowski, Daniel W. Nixon, George L. Blackburn, Peter Jochimsen, Edward F. Scanlon, William Insull Jr, I. Marilyn Buzzard, Robert Elashoff, Ritva Butrum & Ernst L. Wynder

  5. Lipid Research Clinic, Houston, TX, USA

    Rowan T. Chlebowski, Daniel W. Nixon, George L. Blackburn, Peter Jochimsen, Edward F. Scanlon, William Insull Jr, I. Marilyn Buzzard, Robert Elashoff, Ritva Butrum & Ernst L. Wynder

  6. University of Minnesota School of Public Health, Minneapolis, MN, USA

    Rowan T. Chlebowski, Daniel W. Nixon, George L. Blackburn, Peter Jochimsen, Edward F. Scanlon, William Insull Jr, I. Marilyn Buzzard, Robert Elashoff, Ritva Butrum & Ernst L. Wynder

  7. UCLA School of Public Health, Los Angeles, CA, USA

    Rowan T. Chlebowski, Daniel W. Nixon, George L. Blackburn, Peter Jochimsen, Edward F. Scanlon, William Insull Jr, I. Marilyn Buzzard, Robert Elashoff, Ritva Butrum & Ernst L. Wynder

  8. The National Cancer Institute, Bethesda, MD, USA

    Rowan T. Chlebowski, Daniel W. Nixon, George L. Blackburn, Peter Jochimsen, Edward F. Scanlon, William Insull Jr, I. Marilyn Buzzard, Robert Elashoff, Ritva Butrum & Ernst L. Wynder

  9. the American Health Foundation, New York, NY, USA

    Rowan T. Chlebowski, Daniel W. Nixon, George L. Blackburn, Peter Jochimsen, Edward F. Scanlon, William Insull Jr, I. Marilyn Buzzard, Robert Elashoff, Ritva Butrum & Ernst L. Wynder

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  1. Rowan T. Chlebowski
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  2. Daniel W. Nixon
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  3. George L. Blackburn
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  4. Peter Jochimsen
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  5. Edward F. Scanlon
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  6. William Insull Jr
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  7. I. Marilyn Buzzard
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  8. Robert Elashoff
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  9. Ritva Butrum
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  10. Ernst L. Wynder
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Chlebowski, R.T., Nixon, D.W., Blackburn, G.L. et al. A breast cancer nutrition adjuvant study (NAS): Protocol design and initial patient adherence. Breast Cancer Res Tr 10, 21–29 (1987). https://doi.org/10.1007/BF01806131

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