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Bone mineral density in women with breast cancer treated with adjuvant tamoxifen for at least two years

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Summary

While in limited animal studies tamoxifen is reported to protect against loss of bone mineral, data in humans are lacking. We measured bone mineral density (BMD) using single photon absorptiometry at the radius and dual photon absorptiometry at the lumbar spine in breast cancer patients treated with chemotherapy at our institution. In this group, 37 women were not treated with tamoxifen (NT) and 48 women were treated with tamoxifen (T) for at least two years. Younger age, greater weight and height, premenopausal status, and shorter time since menopause were found to be significant predictors of greater BMD. Tamoxifen-treated women had been postmenopausal for more years (p = 0.012). Regression analyses used to adjust for differences in risk of bone loss did not reveal significant differences in BMD between the two groups of women. For the postmenopausal women (27 NT and 34 T subjects), the adjusted mean BMD (g/cm2) at the spine was 1.11 (NT), 1.11 (T) (p = 0.93); and at the radius 0.63 (NT), 0.62 (T) (p = 0.30). This limited retrospective study suggests that tamoxifen does not have ‘anti-estrogenic’ effects on BMD.

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Authors and Affiliations

  1. Department of Human Oncology, University of Wisconsin Center for Health Sciences and the University of Wisconsin Clinical Cancer Center, Madison, Wisconsin, USA

    Richard R. Love, Douglass C. Tormey, Polly A. Newcomb & V. Craig Jordan

  2. Department of Medical Physics, University of Wisconsin Center for Health Sciences and the University of Wisconsin Clinical Cancer Center, Madison, Wisconsin, USA

    Richard B. Mazess

  3. Department of Lunar Radiation, University of Wisconsin Center for Health Sciences and the University of Wisconsin Clinical Cancer Center, Madison, Wisconsin, USA

    Richard B. Mazess & Howard S. Barden

Authors
  1. Richard R. Love
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  2. Richard B. Mazess
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  3. Douglass C. Tormey
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  4. Howard S. Barden
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  5. Polly A. Newcomb
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  6. V. Craig Jordan
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Additional information

Address all inquiries and reprint requests to: Dr. Richard R. Love, K4/6, Clinical Sciences Center, 600 Highland Avenue, Madison, WI 53792, USA

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Love, R.R., Mazess, R.B., Tormey, D.C. et al. Bone mineral density in women with breast cancer treated with adjuvant tamoxifen for at least two years. Breast Cancer Res Tr 12, 297–302 (1988). https://doi.org/10.1007/BF01811242

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  • DOI: https://doi.org/10.1007/BF01811242

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