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Cardiovascular responses to various autonomic tests in males and females

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Abstract

The results of cardiovascular autonomic reflex tests on 224 healthy, randomly selected subjects were analysed to study possible sex differences in the autonomic responses. The heart rate response to the Valsalva manoeuvre (Valsalva ratio) was greater in females over 50 years than in males of the same age (1.58 ± 0.34 vs. 1.44 ± 0.30,p < 0.05). The heart rate response to deep breathing (E/I ratio) was higher in females under 50 years than in males under 50 years (1.37 ± 0.17 vs. 1.34 ± 0.18,p < 0.001). The diastolic blood pressure response to isometric handgrip was higher in males under 50 years than in females of the same age (p < 0.05). Although there were sex differences in the magnitude of the responses, the effect of age was similar in males and females and accelerated attenuation of the autonomic responses could not be demonstrated with increasing age. It can be concluded that significant sex differences exist in cardiovascular autonomic responses. The implication of such differences need consideration.

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References

  1. Ewing DJ. Recent advances in the non-invasive investigation of diabetic autonomic neuropathy. In Bannister R, ed.Autonomic failure. A textbook of clinical disorders of the autonomic nervous system. Oxford University Press, 1988: 667–689.

  2. Kaijser L, Sachs C. Autonomic cardiovascular responses in old age.Clin Physiol 1985;5: 347–357.

    PubMed  Google Scholar 

  3. O'Brien IAD, O'Hare P, Corrall RJM. Heart rate variability in healthy subjects: effect of age and the derivation of normal ranges for tests of autonomic function.Br Heart J 1986;55: 348–354.

    PubMed  Google Scholar 

  4. Chu T, Tsai T, Lai J, Chen W. Evaluation of cardiovascular autonomic function tests in normal subjects.J Formosan Med Assoc 1989;88: 404–406.

    Google Scholar 

  5. Storm DS, Metzger BL, Therrien B. Effects of age on autonomic cardiovascular responsiveness in healthy men and women.Nursing Research 1989;38: 326–330.

    PubMed  Google Scholar 

  6. Tamura N, Shimazu K, Yamamoto T, Watanabe S, Onoda A, Nakazato Y, Hamagichi K. Differential changes in cardiovascular autonomic system function as related to age and gender.Auton Nerv Syst 1989;26: 498–507.

    Google Scholar 

  7. Frey MAB, Port CJM. Sex differences in response to orthostatic and other stresses. In: Smith JJ, ed.Circulatory response to the upright posture. CRC Press, Boca Raton, 1990.

    Google Scholar 

  8. Ingall TJ, McLeod JG, O'Brien PC. The effect of ageing on autonomic nervous system function.Aust NZ J Med 1990;20: 570–577.

    Google Scholar 

  9. Schondorf RI, Low PA. Gender related differences in the cardiovascular responses to upright tilt in normal subjects.Clin Auton Res 1992;2: 183–187.

    PubMed  Google Scholar 

  10. Piha SJ, Seppänen A. Observations based on 10-year's experience of non-invasive cardiovascular reflex testing of autonomic function from a rehabilitation research centre.Clin Auton Res 1991;1: 289–296.

    PubMed  Google Scholar 

  11. Piha SJ. Cardiovascular autonomic reflex tests: normal responses and age-related reference values.Clin Physiol 1991;11: 277–290.

    PubMed  Google Scholar 

  12. Stoney CM, Davis MC, Matthews KA. Sex differences in physiological responses to stress and in coronary heart disease: a causal link?Psychophysiology 1987;24: 127–131.

    PubMed  Google Scholar 

  13. van Dijk JG, Koenderink M, Zwinderman AH, Haan J, Kramer CGS, den Heijer JC. Autonomic nervous system tests depend on resting heart rate and blood pressure.J Auton Nerv Syst 1991;35: 15–24.

    PubMed  Google Scholar 

  14. Wieling W. Heart rate variability in healthy subjects: effect of age and derivation of normal ranges for tests of autonomic function (Ietter).Br Heart J 1987;57: 109–110.

    PubMed  Google Scholar 

  15. Gautschy B, Weidmann P, Gnädinger MP. Autonomic function tests as related to age and gender in normal man.Klin Wochenschr 1986;64: 499–505.

    PubMed  Google Scholar 

  16. Vita G, Princi P, Calabro R, Toscano A, Manna L, Messina C. Cardiovascular reflex tests. Assessment of age-adjusted normal range.J Neurol Sci 1986;75: 263–274.

    PubMed  Google Scholar 

  17. Matthews KA, Stoney CM. Influences of sex and age on cardiovascular responses during stress.Psychosomatic Medicine 1988;50: 46–56.

    PubMed  Google Scholar 

  18. Sumimoto T, Hamada M, Muneta S,et al.. Influence of age and severity of hypertension on blood pressure response to isometric handgrip exercise.J Human Hypertens 1991;5: 399–403.

    Google Scholar 

  19. Taylor JA, Hand GA, Johnson DG, Seals DR. Sympathoadrenalcirculatory regulation during sustained isometric exercise in young and older men.Am J Physiol 1991;261 (5Pt2): R1061-R1069.

    PubMed  Google Scholar 

  20. Ziegler D, Laux G, Dannehl K, Spüler M, Mühlen H, Mayer P, Gries FA. Assessment of cardiovascular autonomic function: age-related normal ranges and reproducibility of spectral analysis, vector analysis, and standard tests of heart rate variation and blood pressure responses.Diabetic Medicine 1992;9: 166–175.

    PubMed  Google Scholar 

  21. Kaijser L. The indirect method of recording blood pressure during exercise—can the diastolic pressure be measured?Clin Physiol 1987;7: 175–179.

    PubMed  Google Scholar 

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  1. The Research Centre of the Social Insurance Institution, Peltoantie 3, SF-20720, Turku, Finland

    Sampo J. Piha MD, PhD

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  1. Sampo J. Piha MD, PhD
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Piha, S.J. Cardiovascular responses to various autonomic tests in males and females. Clinical Autonomic Research 3, 15–20 (1993). https://doi.org/10.1007/BF01819138

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  • DOI: https://doi.org/10.1007/BF01819138

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