Abstract
Although described initially in children, typhlitis is an important clinical condition that may also occur in adults with hematologic malignancy or, less commonly, aplastic anemia. We describe 6 adult patients with typhlitis and review the salient features of this condition. In typhlitis, a necrotizing process of multifactorial origin involves the right colon alone or the right colon and other areas of the intestine as well. Secondary colonization of mucosal ulcers by colonic flora commonly leads to septicemia and pyrexia. Typhlitis may be associated with a variety of clinical and radiographic findings. However, a high index of suspicion and certain constellations of clinical and radiographic findings may lead to an accurate presumptive diagnosis of typhlitis, followed by the institution of appropriate therapy. Notwithstanding, the short-term prognosis for typhlitis remains poor.
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References
Wagner ML, Rosenberg HS, Fernbach DJ, Singleton EB: Typhlitis: a complication of leukemia in childhood.AJR 109:341–350, 1970
Amromin GD, Solomon RD: Necrotizing enteropathy, a complication of treated leukemia or lymphoma patients.JAMA 182:23–29, 1962
Steinberg D, Gold J, Brodin A: Necrotizing enterocolitis in leukemia.Arch Intern Med 131:538–544, 1973
Del Fava RL, Cronin TG: Typhlitis complicating leukemia in an adult: barium enema findings.AJR 129:347–348, 1977
Dworkin B, Winawer SJ, Lightdale CJ: Typhlitis: report of a case with long-term survival and a review of the recent literature.Dig Dis Sci 26:1032–1037, 1981
Klener P, Donner L, Bocanova M, Ort J: Gastrointestinal lesions and complications in haemoblastoses.Folia Haematol (Leipz) 100:57–66, 1973
Lea JW Jr, Masys DR, Shackford SR: Typhlitis: a treatable complication of acute leukemia therapy.Cancer Clin Trials 3:355–362, 1980
Dosik GM, Luna M, Valdivieso M, McCredie KB, Gehan EA, Gil-Extremera B, Smith TL, Bodey GB: Necrotizing colitis in patients with cancer.Am J Med 67:646–656, 1979
Gildenborn HL, Springer EB, Amromin GD: Necrotizing enteropathy: roentgenographic features.AJR 88:942–952, 1962
Moir DH, Bale PM: Necropsy findings in childhood leukemia, emphasizing neutropenic enterocolitis and cerebral calcification.Pathology 8:247–258, 1976
Prolla JC, Kirsner JB: The gastrointestinal lesions and complications of the leukemias.Ann Intern Med 61:1084–1103, 1964
Siegal DL, Bernstein WC: Gastrointestinal complications of the leukemias.Dis Colon Rectum 8:377–381, 1965
Slavin RE, Dias MA, Saral R: Cytosine arabinoside induced gastrointestinal toxic alterations in sequential chemotherapeutic protocols: a clinical-pathologic study of 33 patients.Cancer 42:1747–1759, 1978
Pokorney BH, Jones JM, Shaikh BS, Aber RC: Typhlitis: a treatable cause of recurrent septicemia.JAMA 243:682–683, 1980
Schottenfeld LE, Diamond D: Unrecognized leukemia simulating apparent surgical conditions.Am J Surg 85:669–672, 1953
Cronin TG, Calandra JD, Del Fava RL: Typhlitis presenting as toxic cecitis.Radiology 138:29–30, 1981
Sherman NJ, Williams K, Woolley MM: Surgical complications in the patient with leukemia.J Pediatr Surg 8:235–244, 1973
Varki AP, Armitage JO, Feagler JR: Typhlitis in acute leukemia: successful treatment by early surgical intervention.Cancer 43:695–691, 1979
Ikard I: Neutropenic typhlitis in the adult.Arch Surg 116:943–945, 1981
Shaked A, Shinar E, Freund H: Neutropenic typhlitis: a plea for conservatism.Dis Colon Rectum 26:351–352, 1983
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Taylor, A.J., Dodds, W.J., Gonyo, J.E. et al. Typhlitis in adults. Gastrointest Radiol 10, 363–369 (1985). https://doi.org/10.1007/BF01893133
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DOI: https://doi.org/10.1007/BF01893133