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Renal effects of the inhibitor of thromboxane A2-synthetase OKY-046

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Summary

Acute renal failure (ARF) was associated with increased urinary thromboxane (TXA2) excretion and lessened excretion of sodium (UNaV) and fractional excretion of sodium (FENa%). The inhibitor of thromboxane A2-synthetase OKY-046 enhanced sodium excretion and fractional excretion of sodium in normal and saline loaded animals whereas it partially prevented the reduction in sodium excretion and creatinine clearance and significantly increased fractional excretion of sodium in glycerol treated rats suggesting a partial protection against the development of acute renal failure.

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Authors and Affiliations

  1. Laboratoire de Recherches sur les Hormones Vasoactives et Natriurétiques, INSERM U. 28, Hôpital Broussais, 96 Rue Didot, F-75014, Paris, France

    C. Hatziantoniou & N. Papanikolaou

Authors
  1. C. Hatziantoniou
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  2. N. Papanikolaou
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Additional information

Acknowledgment. This work was supported by the Public Benefit Foundation ‘Alexander S. Onassis’ (G-73). We thank ONO Pharmaceutical Co. Ltd, Kissei Pharmaceutical Co. Ltd, Osaka, Japan, and Dr A Hornych for their generous donations of OKY-046 and anti6keto-PGF1a antibodies respectively.

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Hatziantoniou, C., Papanikolaou, N. Renal effects of the inhibitor of thromboxane A2-synthetase OKY-046. Experientia 42, 613–615 (1986). https://doi.org/10.1007/BF01955558

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