Abstract
This study examines the exacerbating factors of hyeruricaemia in patients with cyanotic congenital heart disease (CCHD). We studied 59 CCHD patients aged 1 month-30 years. The following variables were assessed: serum uric acid levels, red blood cell count, haemoglobin, hematocrit, partial oxygen pressure and arterial oxygen saturation. Uric acid excretion and renal function were also measured in ten patients with serum levels of uric acid greater than 8 mg/dl (hyperuricaemia group). Serum uric acid level correlated significantly with age and severity of polycythaemia. However, it did not correlate with partial oxygen pressure or arterial oxygen saturation. Uric acid excretion was measured in hyperuricaemia group. Urinary uric acid excretion (24 h) was within normal limits in infants but markedly lower in patients over 15 years of age. The aetiology of hyperuricaemia and decreased uric acid fractional excretion and clearance in infants appears to be secondary to diminished excretion of uric acid in concert with uric acid overproduction. Hyperuricaemia in adolescents and adults with CCHD, however, results mainly from age-related impairment of uric acid excretion.
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Abbreviations
- CCHD:
-
cyanotic congenital heart disease
References
Baldree LA, Stapleton FB (1990) Uric acid metabolism in children. Pediatr Clin North Am 37:391–418
Barlow KA, Beilin LJ (1968) Renal disease in primary gout. Q J Med 37:79–96
Burke JR, Glasgow EF, McCredie DA, Powell HR (1977) Nephropathy in cyanotic congenital heart disease. Clin Nephrol 7:38–42
Chonko AM, Grantham JJ (1981) Disorders of urate metabolism and excretion. In: Brenner BM, Rector FC (eds) The kidney. W. B. Saunders, Philadelphia, pp 1023–1055
Dearth JC, Tompkins RB, Giuliani ER, Feldt RH (1978) Hyperuricemia in congenital heart disease. Am J Dis Child 132: 900–902
Gonzales R, Michael A (1987) The urinary system. In: Berman RE, Vaughan VC (eds) Nelson textbook of pediatrics, 13th edn. W. B. Saunders, Philadelphia, pp 1111–1169
Jung K, Schulze B, Sydow K (1987) Diagnostic significance of different urinary enzymes in patients suffering from chronic renal disease. Clin Chim Acta 168:287–295
Klinenberg JR, Gonick HC, Dornfeld L (1975) Renal function abnormalities in patients with asymptomatic hyperuricemia. Arthritis Rheum 18:725–730
Mace Se, Newman AJ, Liebman J (1984) Impairment of urate excretion in patients with cardiac disease. Am J Dis Child 138: 1067–1070
Passwell J, Orda S, Mordan M, Shem-Tov A, Aladjem M, Boichis H (1976) Abnormal renal functions in cyanotic heart disease. Arch Dis Child 51:803–804
Perloff JK, Rosove MH, Child JS, Wright GB (1988) Adults with cyanotic congenital heart disease: Hematologic management. Ann Intern Med 109:406–413
Ross EA, Perloff JK, Danovitch GM, Child JS, Canobbio MM (1986) Renal function and urate metabolism in late survivors with cyanotic congenital heart disease. Circulation 73:396–400
Sommerville J (1961) Gout in cyanotic congenital heart disease. Br Heart J 23:31–34
Woolliscroft JO, Colfer H, Fox IH (1982) Hyperuricemia in acute illness: a poor prognosis sign. Am J Med 72:58–62
Yoshino M, Murakami K, Katsumata Y, Takabayashi A, Mori S (1986) Stimulation of glycolysis with hyperuricemia in rats at high altitude hypoxia. Biomed Res 7:113–117
Young D (1980) Hyperuricemia in cyanotic congenital heart disease. Am J Dis Child 134:902–903
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Hayabuchi, Y., Matsuoka, S., Akita, H. et al. Hyperuricaemia in cyanotic congenital heart disease. Eur J Pediatr 152, 873–876 (1993). https://doi.org/10.1007/BF01957519
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DOI: https://doi.org/10.1007/BF01957519