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Influence of protein binding and severity of illness on renal elimination of four cephalosporin drugs in intensive-care patients

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Abstract

A pharmacokinetic study after a single dose of ceftriaxone, cefoxitin, cefuroxime and ceftazidime was performed to investigate the influence of protein binding and severity of disease on the renal elimination. In intensive-care patients drug-protein binding was substantially less compared to that in volunteers and patients with less complicated diseases. This did not result in increased elimination but, due to increased apparent volumes of distribution, prolonged half-life times were observed. Consequently, in patients with complicated disease states a dosage regimen should be based on pharmacokinetic studies performed in a similar patient group.

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Authors and Affiliations

  1. Department of Intensive Care, St. Radboud Hospital, P.O. Box 9101, 6500, HB Nijmegen, The Netherlands

    Roelof Van Dalen

  2. Department of Clinical Pharmacy, St. Radboud Hospital, P.O. B0X9101, 6500, HB Nijmegen, The Netherlands

    Tom B. Vree & Ita M. Baars

Authors
  1. Roelof Van Dalen
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  2. Tom B. Vree
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  3. Ita M. Baars
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Van Dalen, R., Vree, T.B. & Baars, I.M. Influence of protein binding and severity of illness on renal elimination of four cephalosporin drugs in intensive-care patients. Pharmaceutisch Weekblad Scientific Edition 9, 98–103 (1987). https://doi.org/10.1007/BF01960743

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  • DOI: https://doi.org/10.1007/BF01960743

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